| RS748695956 |
SYNE1
|
Health Risk |
Likely pathogenic |
— |
| RS748696533 |
FRAS1
|
Health Risk |
Pathogenic |
Fraser syndrome 1, Fraser syndrome 1 |
| RS74869729 |
TARBP1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS748698490 |
TSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Isolated focal cortical dysplasia type II |
| RS748698776 |
PMS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary nonpolyposis colorectal neoplasms |
| RS748699921 |
KAT8
|
Health Risk |
Pathogenic |
Li-Ghorbani-Weisz-Hubshman syndrome, Li-Ghorbani-Weisz-Hubshman syndrome |
| RS748700116 |
MEN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Multiple endocrine neoplasia, type 1 |
| RS748700245 |
SETX
|
Health Risk |
Likely pathogenic |
— |
| RS748700385 |
MUTYH
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 2 |
| RS748702655 |
USH2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinitis pigmentosa 39, Usher syndrome type 2A |
| RS748702892 |
SYNGAP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual disability, autosomal dominant 5 |
| RS748704263 |
DYSF
|
Health Risk |
Conflicting classifications of pathogenicity |
Neuromuscular disease caused by qualitative or quantitative defects of dysferlin, Neuromuscular disease caused by qualitative or quantitative defects of dysferlin |
| RS748704459 |
GNE
|
Health Risk |
Pathogenic/Likely pathogenic |
GNE myopathy, Sialuria |
| RS748705687 |
FBXL4
|
Health Risk |
Conflicting classifications of pathogenicity |
Mitochondrial DNA depletion syndrome 13, FBXL4-related disorder |
| RS748706373 |
KCNH2
|
Health Risk |
Pathogenic |
Cardiovascular phenotype, Long QT syndrome |
| RS748706582 |
ABCA4
|
Health Risk |
Likely pathogenic |
Cone-rod dystrophy 3, Severe early-childhood-onset retinal dystrophy |
| RS748706627 |
PCDH15
|
Health Risk |
Pathogenic/Likely pathogenic |
Usher syndrome type 1F, Autosomal recessive nonsyndromic hearing loss 23 |
| RS748707745 |
NSD2
|
Health Risk |
Pathogenic |
Rauch-Steindl syndrome, Rauch-Steindl syndrome |
| RS748708268 |
CYP1B1
|
Health Risk |
Conflicting classifications of pathogenicity |
Glaucoma 3A, Irido-corneo-trabecular dysgenesis |
| RS748709116 |
ALMS1
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinal dystrophy, Alstrom syndrome |
| RS748709396 |
RP1
|
Health Risk |
Pathogenic |
Retinitis pigmentosa 1, Retinal dystrophy |
| RS748710466 |
CLN3
|
Health Risk |
Pathogenic/Likely pathogenic |
Neuronal ceroid lipofuscinosis, Neuronal ceroid lipofuscinosis 3 |
| RS748710535 |
FANCD2
|
Health Risk |
Conflicting classifications of pathogenicity |
Fanconi anemia, Fanconi anemia complementation group D2 |
| RS748711395 |
CACNA1S
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypokalemic periodic paralysis, type 1 |
| RS748711517 |
FLVCR2
|
Health Risk |
Pathogenic |
Inborn genetic diseases, Inborn genetic diseases |
| RS748712495 |
MAN2B1
|
Health Risk |
Pathogenic/Likely pathogenic |
Deficiency of alpha-mannosidase, MAN2B1-related disorder |
| RS748712609 |
PEX13
|
Health Risk |
Conflicting classifications of pathogenicity |
Peroxisome biogenesis disorder 11A (Zellweger), Peroxisome biogenesis disorder 11A (Zellweger) |
| RS748713183 |
FANCA
|
Health Risk |
Conflicting classifications of pathogenicity |
Fanconi anemia, Fanconi anemia complementation group A |
| RS748714111 |
HNF4A
|
Health Risk |
Conflicting classifications of pathogenicity |
Maturity-onset diabetes of the young type 1, Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young |
| RS748714307 |
BRCA1
|
Health Risk |
Pathogenic |
Breast-ovarian cancer, familial |
| RS748714439 |
DDHD1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary spastic paraplegia, Hereditary spastic paraplegia 28 |
| RS748715725 |
RYR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiomyopathy, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS748716950 |
ABCB11
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive familial intrahepatic cholestasis type 2, Progressive familial intrahepatic cholestasis type 2 |
| RS748716996 |
AGRN
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital myasthenic syndrome 8, Inborn genetic diseases |
| RS748717377 |
SYNE1
|
Health Risk |
Conflicting classifications of pathogenicity |
Emery-Dreifuss muscular dystrophy 4, autosomal dominant |
| RS748717639 |
TBX19
|
Health Risk |
Likely pathogenic |
Congenital isolated adrenocorticotropic hormone deficiency, See cases |
| RS748717860 |
RB1
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinoblastoma, Hereditary cancer-predisposing syndrome |
| RS748718937 |
STRC
|
Health Risk |
Conflicting classifications of pathogenicity |
STRC-related disorder, STRC-related disorder |
| RS748718975 |
DPT
|
Health Risk |
Pathogenic |
Progressive sensorineural hearing impairment, Progressive sensorineural hearing impairment |
| RS748719643 |
ATP6V0A4
|
Health Risk |
Likely pathogenic |
ATP6V0A4-related disorder, ATP6V0A4-related disorder |
| RS748719662 |
ABAT
|
Health Risk |
Likely pathogenic |
Gamma-aminobutyric acid transaminase deficiency, Gamma-aminobutyric acid transaminase deficiency |
| RS748720012 |
TUBGCP6
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748721463 |
DOCK8
|
Health Risk |
Conflicting classifications of pathogenicity |
Combined immunodeficiency due to DOCK8 deficiency, Combined immunodeficiency due to DOCK8 deficiency |
| RS748722289 |
SLC26A4
|
Health Risk |
Likely pathogenic |
Autosomal recessive nonsyndromic hearing loss 4, Autosomal recessive nonsyndromic hearing loss 4 |
| RS748723735 |
SPTLC1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary sensory and autonomic neuropathy type 1, Charcot-Marie-Tooth disease |
| RS748724067 |
PHF21A
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748724870 |
AP5Z1
|
Health Risk |
Pathogenic/Likely pathogenic |
Hereditary spastic paraplegia 48, Macular dystrophy with or without extraocular features |
| RS748725549 |
XKR7
|
Health Risk |
Likely pathogenic |
Moyamoya angiopathy, Moyamoya angiopathy |
| RS748725556 |
ALPK3
|
Health Risk |
Pathogenic |
Cardiomyopathy, familial hypertrophic 27 |
| RS748726158 |
PTCH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Gorlin syndrome, Hereditary cancer-predisposing syndrome |
| RS748727021 |
RAG2
|
Health Risk |
Pathogenic |
Combined immunodeficiency with skin granulomas, Severe combined immunodeficiency |
| RS748727595 |
APOB
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial hypobetalipoproteinemia 1, Hypercholesterolemia |
| RS748727674 |
PTCH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Gorlin syndrome |
| RS748728165 |
ZNF423
|
Health Risk |
Conflicting classifications of pathogenicity |
Nephronophthisis 14, Nephronophthisis 14 |
| RS748728894 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS748729107 |
PALLD
|
Health Risk |
Conflicting classifications of pathogenicity |
Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS748730134 |
FANCG
|
Health Risk |
Pathogenic |
Fanconi anemia, Fanconi anemia |
| RS748730384 |
ETFB
|
Health Risk |
Conflicting classifications of pathogenicity |
Multiple acyl-CoA dehydrogenase deficiency, Multiple acyl-CoA dehydrogenase deficiency |
| RS748731866 |
COCH
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant nonsyndromic hearing loss 9, COCH-related disorder |
| RS748732150 |
SCN5A
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiac arrhythmia, Cardiovascular phenotype |
| RS748732850 |
BBS10
|
Health Risk |
Conflicting classifications of pathogenicity |
Bardet-Biedl syndrome, Bardet-Biedl syndrome 10 |
| RS748732950 |
COG1
|
Health Risk |
Conflicting classifications of pathogenicity |
COG1 congenital disorder of glycosylation, COG1-related disorder |
| RS748733167 |
TSC1
|
Health Risk |
Conflicting classifications of pathogenicity |
Tuberous sclerosis 1, Hereditary cancer-predisposing syndrome |
| RS748733661 |
KDM1A
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS748733750 |
DSP
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic right ventricular dysplasia 8, Arrhythmogenic cardiomyopathy with wooly hair and keratoderma |
| RS748735420 |
OTUD6B
|
Health Risk |
Pathogenic/Likely pathogenic |
Intellectual developmental disorder with dysmorphic facies, seizures |
| RS748737164 |
GATA4
|
Health Risk |
Conflicting classifications of pathogenicity |
Atrial septal defect 2, Atrioventricular septal defect 4 |
| RS748739254 |
SLC34A3
|
Health Risk |
Pathogenic/Likely pathogenic |
Autosomal recessive hypophosphatemic bone disease, Autosomal recessive hypophosphatemic bone disease |
| RS748739874 |
SCN2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Developmental and epileptic encephalopathy, 11 |
| RS748740454 |
KMT2D
|
Health Risk |
Conflicting classifications of pathogenicity |
Kabuki syndrome, Kabuki syndrome |
| RS748740551 |
HOXB13
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Prostate cancer |
| RS748743312 |
RYR1
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital multicore myopathy with external ophthalmoplegia, Malignant hyperthermia |
| RS748744542 |
LTBP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Glaucoma 3, primary congenital |
| RS748744950 |
ARG1
|
Health Risk |
Pathogenic |
Arginase deficiency, Arginase deficiency |
| RS748745776 |
APC
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 1 |
| RS748746281 |
PCARE
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinitis pigmentosa, Retinitis pigmentosa |
| RS748746313 |
DST
|
Health Risk |
Likely pathogenic |
Hereditary sensory and autonomic neuropathy type 6, Epidermolysis bullosa simplex 3 |
| RS748746951 |
MYBPC3
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiomyopathy, Hypertrophic cardiomyopathy |
| RS748747434 |
SCN1A
|
Health Risk |
Conflicting classifications of pathogenicity |
Early-infantile DEE, Early-infantile DEE |
| RS748747814 |
TAF1
|
Health Risk |
Uncertain significance; association |
Intellectual disability, X-linked |
| RS74874838 |
USH2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Usher syndrome type 2A, Retinitis pigmentosa |
| RS748749077 |
BCL11B
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748749433 |
USH1C
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS748749585 |
INS
|
Health Risk |
Pathogenic/Likely pathogenic |
Permanent neonatal diabetes mellitus, Maturity-onset diabetes of the young type 10 |
| RS748750637 |
PDE6B
|
Health Risk |
Pathogenic |
— |
| RS748752465 |
DMD
|
Health Risk |
Conflicting classifications of pathogenicity |
Duchenne muscular dystrophy, Becker muscular dystrophy |
| RS748753862 |
ARSA
|
Health Risk |
Likely pathogenic |
Metachromatic leukodystrophy, Metachromatic leukodystrophy |
| RS748754134 |
NDUFS8
|
Health Risk |
Conflicting classifications of pathogenicity |
Leigh syndrome, Mitochondrial complex I deficiency |
| RS748754551 |
AXIN2
|
Health Risk |
Conflicting classifications of pathogenicity |
Oligodontia-cancer predisposition syndrome, Hereditary cancer-predisposing syndrome |
| RS748755041 |
AHDC1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748755187 |
SOX10
|
Health Risk |
Conflicting classifications of pathogenicity |
PCWH syndrome, Waardenburg syndrome type 4C |
| RS748756180 |
MRE11
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Ataxia-telangiectasia-like disorder |
| RS748756524 |
MVK
|
Health Risk |
Conflicting classifications of pathogenicity |
Hyperimmunoglobulin D with periodic fever, Mevalonic aciduria |
| RS748757085 |
BRCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS748757906 |
F13B
|
Health Risk |
Pathogenic |
Factor XIII, b subunit |
| RS748758201 |
BBS4
|
Health Risk |
Conflicting classifications of pathogenicity |
Bardet-Biedl syndrome, Retinitis pigmentosa |
| RS748758448 |
LSS
|
Health Risk |
Conflicting classifications of pathogenicity |
Alopecia-intellectual disability syndrome 4, LSS-related disorder |
| RS748759187 |
TBC1D24
|
Health Risk |
Likely pathogenic |
Familial infantile myoclonic epilepsy, Developmental and epileptic encephalopathy |
| RS748759292 |
ARFGEF2
|
Health Risk |
Conflicting classifications of pathogenicity |
Periventricular heterotopia with microcephaly, autosomal recessive |
| RS7487595 |
POLE
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |