KAT8 Chromosome 16

Lysine acetyltransferase 8
11 variants 11 Health Risk

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What This Gene Does
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Info
Gene Group
"MSL histone acetyltransferase complex|NSL histone acetyltransferase complex|MYST type domain containing lysine acetyltransferases|Zinc fingers MYST C2HC-type"
Locus Type
gene with protein product
Location
16p11.2
Ensembl
ENSG00000103510
Associated Conditions (2)
Li-Ghorbani-Weisz-Hubshman syndrome
Inborn genetic diseases
Key Variants
All Variants (11)
RSID Category Clinical Significance Conditions
RS572043246 Health Risk Conflicting classifications of pathogenicity Li-Ghorbani-Weisz-Hubshman syndrome, Li-Ghorbani-Weisz-Hubshman syndrome
RS2057483219 Health Risk Likely pathogenic Inborn genetic diseases, Li-Ghorbani-Weisz-Hubshman syndrome, Inborn genetic diseases
RS2143985614 Health Risk Likely pathogenic Li-Ghorbani-Weisz-Hubshman syndrome, Li-Ghorbani-Weisz-Hubshman syndrome
RS756211242 Health Risk Likely pathogenic Li-Ghorbani-Weisz-Hubshman syndrome, Li-Ghorbani-Weisz-Hubshman syndrome
RS2057538050 Health Risk Pathogenic Li-Ghorbani-Weisz-Hubshman syndrome, Li-Ghorbani-Weisz-Hubshman syndrome
RS2057538160 Health Risk Pathogenic Li-Ghorbani-Weisz-Hubshman syndrome, Li-Ghorbani-Weisz-Hubshman syndrome
RS2143966219 Health Risk Pathogenic Li-Ghorbani-Weisz-Hubshman syndrome, Li-Ghorbani-Weisz-Hubshman syndrome
RS2143966454 Health Risk Pathogenic
RS2544163458 Health Risk Pathogenic
RS2544163778 Health Risk Pathogenic Inborn genetic diseases, Inborn genetic diseases
RS748699921 Health Risk Pathogenic Li-Ghorbani-Weisz-Hubshman syndrome, Li-Ghorbani-Weisz-Hubshman syndrome
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