| RS74864455 |
TTN
|
Health Risk |
Likely pathogenic |
Autosomal recessive limb-girdle muscular dystrophy type 2J, Dilated cardiomyopathy 1G |
| RS748644914 |
POLE
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS748645037 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS748645116 |
TRIP11
|
Health Risk |
Conflicting classifications of pathogenicity |
Achondrogenesis, type IA |
| RS748648178 |
CACNA1H
|
Health Risk |
Conflicting classifications of pathogenicity |
Idiopathic generalized epilepsy, Hyperaldosteronism |
| RS748648802 |
DHCR24
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748648909 |
MEN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Multiple endocrine neoplasia, type 1 |
| RS748649917 |
ASXL1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748650244 |
PROC
|
Health Risk |
Conflicting classifications of pathogenicity |
Thrombophilia due to protein C deficiency, autosomal dominant |
| RS748650667 |
LAMA2
|
Health Risk |
Conflicting classifications of pathogenicity |
LAMA2-related muscular dystrophy, Congenital muscular dystrophy due to partial LAMA2 deficiency |
| RS748650780 |
DPF2
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748651137 |
EXT1
|
Health Risk |
Conflicting classifications of pathogenicity |
Multiple congenital exostosis, Chondrosarcoma |
| RS748652333 |
NBAS
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748652746 |
PLOD2
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS748654180 |
PKD2
|
Health Risk |
Conflicting classifications of pathogenicity |
Polycystic kidney disease, Polycystic kidney disease 2 |
| RS748654543 |
TG
|
Health Risk |
Likely pathogenic |
— |
| RS748655442 |
CHD7
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypogonadotropic hypogonadism 5 with or without anosmia, CHARGE syndrome |
| RS748655443 |
TK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Mitochondrial DNA depletion syndrome, myopathic form |
| RS748656635 |
WDR19
|
Health Risk |
Pathogenic/Likely pathogenic |
Jeune thoracic dystrophy, Nephronophthisis 13 |
| RS748656792 |
SCN2A
|
Health Risk |
Pathogenic |
Seizures, benign familial infantile |
| RS748657435 |
ABCB4
|
Health Risk |
Pathogenic/Likely pathogenic |
Progressive familial intrahepatic cholestasis type 3, Progressive familial intrahepatic cholestasis |
| RS748657880 |
POLD1
|
Health Risk |
Conflicting classifications of pathogenicity |
Colorectal cancer, susceptibility to |
| RS748658007 |
HPRT1
|
Health Risk |
Conflicting classifications of pathogenicity |
Lesch-Nyhan syndrome, Partial hypoxanthine-guanine phosphoribosyltransferase deficiency |
| RS748658606 |
CEP83
|
Health Risk |
Conflicting classifications of pathogenicity |
Nephronophthisis 18, Inborn genetic diseases |
| RS748659009 |
CPT1C
|
Health Risk |
Pathogenic |
Hereditary spastic paraplegia 73, Hereditary spastic paraplegia 73 |
| RS748659068 |
TCIRG1
|
Health Risk |
Pathogenic |
Autosomal recessive osteopetrosis 1, Autosomal recessive osteopetrosis 1 |
| RS748659198 |
LYST
|
Health Risk |
Likely pathogenic |
— |
| RS748660256 |
ZFYVE27
|
Health Risk |
Conflicting classifications of pathogenicity |
Spastic paraplegia, Spastic paraplegia |
| RS748660310 |
STK4
|
Health Risk |
Pathogenic |
Combined immunodeficiency due to STK4 deficiency, Combined immunodeficiency due to STK4 deficiency |
| RS748662135 |
SLC2A10
|
Health Risk |
Conflicting classifications of pathogenicity |
Arterial tortuosity syndrome, Familial thoracic aortic aneurysm and aortic dissection |
| RS748663329 |
ABCA1
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Cardiovascular phenotype |
| RS748663340 |
ALDOB
|
Health Risk |
Pathogenic/Likely pathogenic |
Hereditary fructosuria, Hereditary fructosuria |
| RS748663568 |
NEMF
|
Health Risk |
Pathogenic |
— |
| RS748663740 |
PRG4
|
Health Risk |
Pathogenic |
Camptodactyly-arthropathy-coxa vara-pericarditis syndrome, Camptodactyly-arthropathy-coxa vara-pericarditis syndrome |
| RS748663904 |
TTC21B
|
Health Risk |
Pathogenic/Likely pathogenic |
Nephronophthisis, Jeune thoracic dystrophy |
| RS748664291 |
TRPS1
|
Health Risk |
Pathogenic |
— |
| RS748664881 |
RSPH4A
|
Health Risk |
Likely pathogenic |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS748665278 |
HCN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Developmental and epileptic encephalopathy, 24 |
| RS748665739 |
TRPM4
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive familial heart block type IB, Cardiovascular phenotype |
| RS748666715 |
FAN1
|
Health Risk |
Pathogenic/Likely pathogenic |
Karyomegalic interstitial nephritis, Karyomegalic interstitial nephritis |
| RS748666817 |
ACAN
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Osteochondritis dissecans |
| RS748666965 |
SOX10
|
Health Risk |
Conflicting classifications of pathogenicity |
SOX10-related disorder, SOX10-related disorder |
| RS748667010 |
CDC73
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hyperparathyroidism 1 |
| RS748667559 |
PRDM5
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS748668603 |
MED12
|
Health Risk |
Conflicting classifications of pathogenicity |
FG syndrome, Familial thoracic aortic aneurysm and aortic dissection |
| RS748668786 |
C2CD3
|
Health Risk |
Conflicting classifications of pathogenicity |
Orofaciodigital syndrome type 14, Orofaciodigital syndrome type 14 |
| RS748669016 |
TSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Tuberous sclerosis 2, Hereditary cancer-predisposing syndrome |
| RS748669377 |
TYR
|
Health Risk |
Pathogenic |
SKIN/HAIR/EYE PIGMENTATION 3, LIGHT/DARK SKIN |
| RS748669519 |
TSC1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Tuberous sclerosis 1 |
| RS748669919 |
KDM4B
|
Health Risk |
Likely pathogenic |
Intellectual developmental disorder, autosomal dominant 65 |
| RS748670315 |
EPG5
|
Health Risk |
Pathogenic |
Vici syndrome, Vici syndrome |
| RS748670822 |
TRIO
|
Health Risk |
Pathogenic/Likely pathogenic |
Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome, Intellectual developmental disorder |
| RS748671901 |
TJP2
|
Health Risk |
Pathogenic |
Cholestasis, progressive familial intrahepatic |
| RS748672083 |
LDLR
|
Health Risk |
Pathogenic |
Hypercholesterolemia, familial |
| RS748672127 |
CEP135
|
Health Risk |
Pathogenic |
Inborn genetic diseases, Inborn genetic diseases |
| RS748672380 |
NTRK1
|
Health Risk |
Pathogenic/Likely pathogenic |
Charcot-Marie-Tooth disease, Hereditary insensitivity to pain with anhidrosis |
| RS748674098 |
APOB
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypercholesterolemia, autosomal dominant |
| RS748674194 |
BRCA1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS748674789 |
SPAST
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary spastic paraplegia 4, Inborn genetic diseases |
| RS748675191 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1G, Autosomal recessive limb-girdle muscular dystrophy type 2J |
| RS748675395 |
BRCA1
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS748676621 |
PIGG
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual disability, autosomal recessive 53 |
| RS748676671 |
CYP24A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypercalcemia, infantile |
| RS748676766 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS748678066 |
SACS
|
Health Risk |
Conflicting classifications of pathogenicity |
Spastic paraplegia, Inborn genetic diseases |
| RS748678280 |
RYR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Cardiomyopathy |
| RS748678337 |
DNAH9
|
Health Risk |
Pathogenic |
— |
| RS748678625 |
MBTPS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748679499 |
NEB
|
Health Risk |
Conflicting classifications of pathogenicity |
Nemaline myopathy 2, Nemaline myopathy 2 |
| RS748680209 |
NPHS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital nephrotic syndrome, Finnish congenital nephrotic syndrome |
| RS748680704 |
GRK1
|
Health Risk |
Pathogenic |
Oguchi disease-2, Retinal dystrophy |
| RS748680802 |
RPS6KA3
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual disability, X-linked 19 |
| RS748681103 |
SKI
|
Health Risk |
Conflicting classifications of pathogenicity |
Shprintzen-Goldberg syndrome, Shprintzen-Goldberg syndrome |
| RS748681475 |
CTSA
|
Health Risk |
Conflicting classifications of pathogenicity |
Combined deficiency of sialidase AND beta galactosidase, Acute myeloid leukemia |
| RS748682601 |
DLD
|
Health Risk |
Pathogenic |
Pyruvate dehydrogenase E3 deficiency, Pyruvate dehydrogenase E3 deficiency |
| RS748684063 |
RAB3GAP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Martsolf syndrome, Warburg micro syndrome 2 |
| RS748684065 |
ELAC2
|
Health Risk |
Pathogenic/Likely pathogenic |
Combined oxidative phosphorylation defect type 17, Combined oxidative phosphorylation defect type 17 |
| RS748684128 |
BEST1
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinal dystrophy, Retinal dystrophy |
| RS748684395 |
GLE1
|
Health Risk |
Pathogenic |
— |
| RS748684688 |
BMPR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Pulmonary hypertension, primary |
| RS748685592 |
BEST1
|
Health Risk |
Pathogenic/Likely pathogenic |
Autosomal recessive bestrophinopathy, Vitelliform macular dystrophy 2 |
| RS748685997 |
MPZL2
|
Health Risk |
Likely pathogenic |
Hearing loss, autosomal recessive 111 |
| RS748686068 |
TPP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Neuronal ceroid lipofuscinosis 2, Autosomal recessive spinocerebellar ataxia 7 |
| RS748687181 |
POLRMT
|
Health Risk |
Pathogenic |
Combined oxidative phosphorylation deficiency 55, Combined oxidative phosphorylation deficiency 55 |
| RS748688174 |
FANCD2
|
Health Risk |
Likely pathogenic |
Fanconi anemia, Fanconi anemia |
| RS748688175 |
GAS8
|
Health Risk |
Pathogenic |
Primary ciliary dyskinesia 33, Primary ciliary dyskinesia 33 |
| RS748689368 |
SLC4A11
|
Health Risk |
Pathogenic |
— |
| RS748689554 |
PEX3
|
Health Risk |
Pathogenic/Likely pathogenic |
Peroxisome biogenesis disorder 10A (Zellweger), Peroxisome biogenesis disorder 10A (Zellweger) |
| RS748689777 |
TTN
|
Health Risk |
Pathogenic/Likely pathogenic |
Autosomal recessive limb-girdle muscular dystrophy type 2J, Dilated cardiomyopathy 1G |
| RS748691653 |
NF1
|
Health Risk |
Conflicting classifications of pathogenicity |
Neurofibromatosis, type 1 |
| RS748691963 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1G, Autosomal recessive limb-girdle muscular dystrophy type 2J |
| RS748692173 |
TSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Tuberous sclerosis 2, Hereditary cancer-predisposing syndrome |
| RS748692597 |
OCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS748692809 |
PALB2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS748693257 |
TTN
|
Health Risk |
Likely pathogenic |
Dilated cardiomyopathy 1A, Dilated cardiomyopathy 1A |
| RS748693944 |
DNAAF2
|
Health Risk |
Pathogenic/Likely pathogenic |
Primary ciliary dyskinesia, Primary ciliary dyskinesia 10 |
| RS748694238 |
LAMA2
|
Health Risk |
Likely pathogenic |
LAMA2-related muscular dystrophy, LAMA2-related muscular dystrophy |
| RS748694848 |
CHRNE
|
Health Risk |
Pathogenic |
Congenital myasthenic syndrome 4A, Congenital myasthenic syndrome 4A |
| RS748694853 |
CHD2
|
Health Risk |
Pathogenic |
Developmental and epileptic encephalopathy 94, Inborn genetic diseases |
| RS748695461 |
CBS
|
Health Risk |
Pathogenic |
Classic homocystinuria, Homocystinuria |