HOXB13 Chromosome 17
Homeobox B13
Upload your DNA to see your personal genotypes for variants in HOXB13.
What This Gene Does
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
HOXL subclass homeoboxes
Locus Type
gene with protein product
Location
17q21.32
Ensembl
ENSG00000159184
Associated Conditions (12)
Hereditary cancer-predisposing syndrome
HOXB13-related disorder
Prostate cancer
hereditary
9
1
Familial prostate cancer
Gastric cancer
Prostate cancer susceptibility
Carcinoma of pancreas
HOXB13-Related Cancer Predisposition
Breast and/or ovarian cancer
Key Variants
RS1249659597
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, HOXB13-related disorder, Prostate cancer
Health Risk
RS1265294177
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary
Health Risk
RS1360003941
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS140492479
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS145059285
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary
Health Risk
RS1484636342
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS148649390
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, HOXB13-related disorder, Hereditary cancer-predisposing syndrome
Health Risk
RS1488986619
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS150413396
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary
Health Risk
RS1555558690
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1567701707
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS199799743
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary
Health Risk
All Variants (45)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1249659597 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, HOXB13-related disorder, Prostate cancer |
| RS1265294177 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS1360003941 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS140492479 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS145059285 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS1484636342 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS148649390 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, HOXB13-related disorder, Hereditary cancer-predisposing syndrome |
| RS1488986619 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS150413396 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS1555558690 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1567701707 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS199799743 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS200997384 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS201428095 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2509515998 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS370167148 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS370361482 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS370934116 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS371544984 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS539706443 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS745392080 | Health Risk | Conflicting classifications of pathogenicity | Prostate cancer, hereditary, 1 |
| RS745889927 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS746542615 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS748333323 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS748740551 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS751698154 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS752322954 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS752722523 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS753501228 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS756654236 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS756970136 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS757155193 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS763353615 | Health Risk | Conflicting classifications of pathogenicity | Prostate cancer, hereditary, 1 |
| RS763448911 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, HOXB13-related disorder, Prostate cancer |
| RS764401781 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS769145488 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS769323553 | Health Risk | Conflicting classifications of pathogenicity | Prostate cancer, hereditary, 1 |
| RS772484566 | Health Risk | Conflicting classifications of pathogenicity | Prostate cancer, hereditary, 1 |
| RS775189167 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS779692736 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS779780541 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Prostate cancer, hereditary |
| RS780012601 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS77179853 | Health Risk | Conflicting classifications of pathogenicity; association | Hereditary cancer-predisposing syndrome, HOXB13-related disorder, Prostate cancer |
| RS2509512772 | Health Risk | Pathogenic | Gastric cancer, Gastric cancer |
| RS138213197 | Health Risk | Pathogenic/Likely pathogenic; association | Prostate cancer susceptibility, Hereditary cancer-predisposing syndrome, Prostate cancer |