PALLD Chromosome 4
Palladin, cytoskeletal associated protein
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What This Gene Does
This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Info
Gene Group
I-set domain containing
Locus Type
gene with protein product
Location
4q32.3
Ensembl
ENSG00000129116
Associated Conditions (10)
Pancreatic adenocarcinoma
Pancreatic cancer
susceptibility to
1
PALLD-related disorder
Ovarian serous cystadenocarcinoma
Gastric cancer
Hereditary cancer-predisposing syndrome
Inborn genetic diseases
Malignant tumor of esophagus
Key Variants
RS114171764
Conflicting classifications of pathogenicity
Pancreatic adenocarcinoma, Pancreatic adenocarcinoma
Health Risk
RS114946738
Conflicting classifications of pathogenicity
Pancreatic cancer, susceptibility to, 1
Health Risk
RS115372194
Conflicting classifications of pathogenicity
Pancreatic cancer, susceptibility to, 1
Health Risk
RS115607645
Conflicting classifications of pathogenicity
Pancreatic cancer, susceptibility to, 1
Health Risk
RS1161219308
Conflicting classifications of pathogenicity
Pancreatic adenocarcinoma, Pancreatic adenocarcinoma
Health Risk
RS116158771
Conflicting classifications of pathogenicity
Pancreatic cancer, susceptibility to, 1
Health Risk
RS116219738
Conflicting classifications of pathogenicity
Pancreatic cancer, susceptibility to, 1
Health Risk
RS1173076751
Conflicting classifications of pathogenicity
Pancreatic adenocarcinoma, Pancreatic adenocarcinoma
Health Risk
RS121908291
Conflicting classifications of pathogenicity
Pancreatic cancer, susceptibility to, 1
Health Risk
RS138897963
Conflicting classifications of pathogenicity
Pancreatic cancer, susceptibility to, 1
Health Risk
RS139375029
Conflicting classifications of pathogenicity
Pancreatic cancer, susceptibility to, 1
Health Risk
RS139434937
Conflicting classifications of pathogenicity
Pancreatic cancer, susceptibility to, 1
Health Risk
All Variants (40)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS114171764 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS114946738 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS115372194 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS115607645 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS1161219308 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS116158771 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS116219738 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS1173076751 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS121908291 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS138897963 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS139375029 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS139434937 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS140236743 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS140454899 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS142116575 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS1431975703 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS1434151476 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS145571230 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS146387060 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS1484758238 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS150711066 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS189021816 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic cancer, susceptibility to |
| RS201038000 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS201343910 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS370602081 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Malignant tumor of esophagus, Pancreatic adenocarcinoma |
| RS371498362 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS376732578 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS532961259 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS535118290 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS551420048 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS587780757 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, PALLD-related disorder, Pancreatic cancer |
| RS587780760 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic cancer, susceptibility to |
| RS748729107 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS750033888 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS750112132 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS757791701 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS763283965 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |
| RS780516159 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS863224702 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic adenocarcinoma, Pancreatic adenocarcinoma |
| RS948639021 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 1 |