| RS745759890 |
ACAD9
|
Health Risk |
Likely pathogenic |
— |
| RS745759931 |
DNAJC21
|
Health Risk |
Pathogenic |
— |
| RS745759959 |
FBN2
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital contractural arachnodactyly, Congenital contractural arachnodactyly |
| RS745760392 |
JPH2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypertrophic cardiomyopathy, Cardiovascular phenotype |
| RS745761673 |
WFS1
|
Health Risk |
Likely pathogenic |
— |
| RS745763201 |
PMS2
|
Health Risk |
Likely pathogenic |
— |
| RS745763431 |
TCF20
|
Health Risk |
Conflicting classifications of pathogenicity |
Developmental delay with variable intellectual impairment and behavioral abnormalities, Inborn genetic diseases |
| RS745763932 |
CRTAP
|
Health Risk |
Pathogenic |
Osteogenesis imperfecta type 7, Osteogenesis imperfecta type 7 |
| RS745763987 |
PEX26
|
Health Risk |
Pathogenic |
Peroxisome biogenesis disorder 7A (Zellweger), Peroxisome biogenesis disorder 7B |
| RS745764335 |
ANK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Long QT syndrome, Cardiovascular phenotype |
| RS745764562 |
CBS
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial thoracic aortic aneurysm and aortic dissection, Homocystinuria |
| RS745764691 |
LMF1
|
Health Risk |
Likely pathogenic |
LMF1-related disorder, LMF1-related disorder |
| RS745765337 |
FANCD2
|
Health Risk |
Conflicting classifications of pathogenicity |
Fanconi anemia complementation group D2, Fanconi anemia |
| RS745765868 |
LRP2
|
Health Risk |
Likely pathogenic |
Donnai-Barrow syndrome, Thyroid cancer |
| RS745766346 |
MATN3
|
Health Risk |
Conflicting classifications of pathogenicity |
Multiple epiphyseal dysplasia type 5, Multiple epiphyseal dysplasia type 5 |
| RS745766441 |
NLRP12
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial cold autoinflammatory syndrome 2, Autoinflammatory syndrome |
| RS745766760 |
ITGB3
|
Health Risk |
Pathogenic |
Glanzmann thrombasthenia, Glanzmann thrombasthenia 2 |
| RS745766916 |
MRE11
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Ataxia-telangiectasia-like disorder |
| RS745766977 |
DMD
|
Health Risk |
Conflicting classifications of pathogenicity |
Duchenne muscular dystrophy, Dystrophin deficiency |
| RS745767539 |
TMC1
|
Health Risk |
Pathogenic |
— |
| RS745768694 |
LMNA
|
Health Risk |
Conflicting classifications of pathogenicity |
Charcot-Marie-Tooth disease type 2, Charcot-Marie-Tooth disease type 2 |
| RS745768777 |
DYRK1A
|
Health Risk |
Pathogenic |
DYRK1A-related intellectual disability syndrome, DYRK1A-related intellectual disability syndrome |
| RS745769829 |
NIPBL
|
Health Risk |
Conflicting classifications of pathogenicity |
Cornelia de Lange syndrome 1, Cornelia de Lange syndrome 1 |
| RS745770134 |
CNTNAP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Cortical dysplasia-focal epilepsy syndrome, Inborn genetic diseases |
| RS745770404 |
PKHD1
|
Health Risk |
Pathogenic/Likely pathogenic |
Autosomal recessive polycystic kidney disease, Polycystic kidney disease 4 |
| RS745771647 |
MSH2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS745772518 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary nonpolyposis colorectal neoplasms |
| RS745772634 |
MED13
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual developmental disorder 61, Intellectual developmental disorder 61 |
| RS745772939 |
ALK
|
Health Risk |
Conflicting classifications of pathogenicity |
Neuroblastoma, susceptibility to |
| RS745773225 |
ATM
|
Health Risk |
Conflicting classifications of pathogenicity |
Ataxia-telangiectasia syndrome, Hereditary cancer-predisposing syndrome |
| RS745773662 |
SMARCB1
|
Health Risk |
Conflicting classifications of pathogenicity |
Rhabdoid tumor predisposition syndrome 1, SMARCB1-related schwannomatosis |
| RS745774108 |
FKRP
|
Health Risk |
Conflicting classifications of pathogenicity |
Walker-Warburg congenital muscular dystrophy, Cardiovascular phenotype |
| RS745774620 |
SLC26A2
|
Health Risk |
Pathogenic/Likely pathogenic |
Multiple epiphyseal dysplasia type 4, Achondrogenesis |
| RS745774658 |
SCN2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Seizure, Seizure |
| RS745775171 |
FLNC
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Distal myopathy with posterior leg and anterior hand involvement |
| RS745775382 |
ATM
|
Health Risk |
Conflicting classifications of pathogenicity |
Ataxia-telangiectasia syndrome, Hereditary cancer-predisposing syndrome |
| RS745775419 |
SETX
|
Health Risk |
Pathogenic |
Amyotrophic lateral sclerosis type 4, Spinocerebellar ataxia |
| RS745775887 |
CACNA1A
|
Health Risk |
Conflicting classifications of pathogenicity |
Episodic ataxia type 2, Developmental and epileptic encephalopathy |
| RS745775933 |
MAN2B2
|
Health Risk |
Likely pathogenic |
— |
| RS745776063 |
MAGEL2
|
Health Risk |
Conflicting classifications of pathogenicity |
MAGEL2-related disorder, MAGEL2-related disorder |
| RS745776539 |
TRIOBP
|
Health Risk |
Pathogenic |
Autosomal recessive nonsyndromic hearing loss 28, TRIOBP-related disorder |
| RS745776915 |
RTEL1
|
Health Risk |
Conflicting classifications of pathogenicity |
Dyskeratosis congenita, autosomal recessive 5 |
| RS745776920 |
KHDC3L
|
Health Risk |
Likely pathogenic |
Hydatidiform mole, recurrent |
| RS745776977 |
LDLR
|
Health Risk |
Likely pathogenic |
Hypercholesterolemia, familial |
| RS745777805 |
NPC1
|
Health Risk |
Likely pathogenic |
Niemann-Pick disease, type C1 |
| RS745778317 |
POLH
|
Health Risk |
Pathogenic |
Xeroderma pigmentosum variant type, Xeroderma pigmentosum variant type |
| RS745782166 |
FREM1
|
Health Risk |
Conflicting classifications of pathogenicity |
Oculotrichoanal syndrome, Trigonocephaly 2 |
| RS745782331 |
BRIP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS745783052 |
BRAF
|
Health Risk |
Conflicting classifications of pathogenicity |
RASopathy, Primary dilated cardiomyopathy |
| RS745783399 |
TDRD1
|
Health Risk |
Likely pathogenic |
Male infertility, Male infertility |
| RS745784432 |
ACE
|
Health Risk |
Conflicting classifications of pathogenicity |
Renal tubular dysgenesis, Renal tubular dysgenesis |
| RS745785393 |
OTOF
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive nonsyndromic hearing loss 9, OTOF-related disorder |
| RS745788222 |
COL2A1
|
Health Risk |
Likely pathogenic |
MASS syndrome, MASS syndrome |
| RS745788940 |
SOS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Noonan syndrome 9, Cardiovascular phenotype |
| RS745789021 |
MOCS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS745789469 |
MKS1
|
Health Risk |
Likely pathogenic |
Bardet-Biedl syndrome 13, Meckel syndrome |
| RS745790694 |
FIG4
|
Health Risk |
Pathogenic/Likely pathogenic |
Charcot-Marie-Tooth disease, Charcot-Marie-Tooth disease type 4J |
| RS745791097 |
NEB
|
Health Risk |
Conflicting classifications of pathogenicity |
Nemaline myopathy 2, Inborn genetic diseases |
| RS745793409 |
ACADM
|
Health Risk |
Pathogenic |
Medium-chain acyl-coenzyme A dehydrogenase deficiency, Medium-chain acyl-coenzyme A dehydrogenase deficiency |
| RS745793517 |
SUFU
|
Health Risk |
Conflicting classifications of pathogenicity |
Gorlin syndrome, Medulloblastoma |
| RS745794356 |
COL2A1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS745795188 |
ADA2
|
Health Risk |
Pathogenic |
Deficiency of adenosine deaminase 2, Deficiency of adenosine deaminase 2 |
| RS745795470 |
EDN3
|
Health Risk |
Likely pathogenic |
Hirschsprung disease, susceptibility to |
| RS745797691 |
MECOM
|
Health Risk |
Conflicting classifications of pathogenicity |
Abnormal bleeding, Thrombocytopenia |
| RS745797941 |
RAD50
|
Health Risk |
Pathogenic/Likely pathogenic |
Hereditary cancer-predisposing syndrome, Nijmegen breakage syndrome-like disorder |
| RS745798632 |
SPTAN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Developmental and epileptic encephalopathy, 5 |
| RS745800110 |
TBC1D24
|
Health Risk |
Pathogenic/Likely pathogenic |
TBC1D24-related disorder, Autosomal dominant nonsyndromic hearing loss 65 |
| RS745800212 |
POLG
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive sclerosing poliodystrophy, Progressive sclerosing poliodystrophy |
| RS745800327 |
COL6A2
|
Health Risk |
Conflicting classifications of pathogenicity |
Bethlem myopathy 1A, Bethlem myopathy 1A |
| RS745800344 |
DRC1
|
Health Risk |
Likely pathogenic |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS745801834 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS745802492 |
DICER1
|
Health Risk |
Conflicting classifications of pathogenicity |
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS745802920 |
AGRN
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital myasthenic syndrome 8, Inborn genetic diseases |
| RS745803719 |
OCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Tyrosinase-positive oculocutaneous albinism, SKIN/HAIR/EYE PIGMENTATION 1 |
| RS745803896 |
NBAS
|
Health Risk |
Pathogenic |
— |
| RS745804153 |
FGA
|
Health Risk |
Likely pathogenic |
Familial dysfibrinogenemia, Familial dysfibrinogenemia |
| RS745804540 |
NF1
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Café-au-lait macules with pulmonary stenosis |
| RS745805590 |
SKIC3
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS745806197 |
AARS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Combined oxidative phosphorylation defect type 8, Combined oxidative phosphorylation defect type 8 |
| RS745806504 |
NPHP1
|
Health Risk |
Likely pathogenic |
Nephronophthisis, Nephronophthisis 1 |
| RS745806637 |
RERE
|
Health Risk |
Conflicting classifications of pathogenicity |
Neurodevelopmental disorder with or without anomalies of the brain, eye |
| RS745806762 |
GMPPA
|
Health Risk |
Pathogenic/Likely pathogenic |
Alacrima, achalasia |
| RS745807085 |
BLM
|
Health Risk |
Pathogenic/Likely pathogenic |
Bloom syndrome, Hereditary cancer-predisposing syndrome |
| RS745807357 |
PRPH2
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinitis pigmentosa, Pigmentary retinal dystrophy |
| RS745807727 |
CDH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary diffuse gastric adenocarcinoma, Hereditary cancer-predisposing syndrome |
| RS745807900 |
POLG
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive sclerosing poliodystrophy, Progressive sclerosing poliodystrophy |
| RS745808344 |
TRIM8
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS745808884 |
SLC26A2
|
Health Risk |
Likely pathogenic |
Achondrogenesis, type IB |
| RS745808996 |
COL9A3
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS745809543 |
GLI3
|
Health Risk |
Conflicting classifications of pathogenicity |
Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome |
| RS745811346 |
MYBPC3
|
Health Risk |
Pathogenic |
Hypertrophic cardiomyopathy, Cardiovascular phenotype |
| RS745811356 |
APC
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, APC-Associated Polyposis Disorders |
| RS745812917 |
KMT2B
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS745812924 |
GATA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Monocytopenia with susceptibility to infections, Deafness-lymphedema-leukemia syndrome |
| RS745813087 |
CEP290
|
Health Risk |
Conflicting classifications of pathogenicity |
Meckel syndrome, type 4 |
| RS745814294 |
NGLY1
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital disorder of deglycosylation, Congenital disorder of deglycosylation 1 |
| RS745815071 |
COL4A4
|
Health Risk |
Conflicting classifications of pathogenicity |
Alport syndrome, Alport syndrome |
| RS745816899 |
PTPRC
|
Health Risk |
Likely pathogenic |
Immunodeficiency 104, Immunodeficiency 104 |
| RS745817076 |
SPTBN4
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Neurodevelopmental disorder with hypotonia |
| RS745817393 |
BRCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |