MOCS1 Chromosome 6
Molybdenum cofactor synthesis 1
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What This Gene Does
Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Nov 2017]
Gene Info
Gene Group
Radical S-adenosylmethionine domain containing
Locus Type
gene with protein product
Location
6p21.2
Ensembl
ENSG00000124615
Associated Conditions (10)
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Inborn genetic diseases
MOCS1-related disorder
Intellectual disability
Glioma susceptibility 1
Hepatocellular carcinoma
Combined molybdoflavoprotein enzyme deficiency
Thyroid cancer
nonmedullary
1
Key Variants
RS104893970
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
RS111640560
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
RS112994296
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
RS113678603
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
RS116035280
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
RS1208715055
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
RS1260936028
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
RS138822116
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
RS140243105
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Intellectual disability, Inborn genetic diseases
Health Risk
RS142478972
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Glioma susceptibility 1
Health Risk
RS143912353
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
RS145146059
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A
Health Risk
All Variants (110)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS104893970 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS111640560 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS112994296 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS113678603 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS116035280 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS1208715055 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS1260936028 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS138822116 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS140243105 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Intellectual disability, Inborn genetic diseases |
| RS142478972 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Glioma susceptibility 1 |
| RS143912353 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS145146059 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS146944225 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS148579886 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Intellectual disability, Inborn genetic diseases |
| RS149233109 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS150131853 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS199797027 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS200316862 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS200764011 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS201889779 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS368402544 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS368776652 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS370411582 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS375882259 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS377167949 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS377424990 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS377628500 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS45487695 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS532400782 | Health Risk | Conflicting classifications of pathogenicity | Intellectual disability, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases |
| RS745789021 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS746138504 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS752653792 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS757431407 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Inborn genetic diseases |
| RS760690355 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS762810343 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS766980859 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS769669172 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Inborn genetic diseases, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS771259156 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS779592342 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS866399151 | Health Risk | Conflicting classifications of pathogenicity | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Intellectual disability, Combined molybdoflavoprotein enzyme deficiency |
| RS1025583289 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS104893969 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, MOCS1-related disorder, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS1275613358 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS1285930895 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS1562085332 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS2149398883 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS2482274768 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS2482284043 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS2482284575 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |
| RS2482284914 | Health Risk | Likely pathogenic | Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A, Sulfite oxidase deficiency due to molybdenum cofactor deficiency type A |