| RS750529207 |
SH3TC2
|
Health Risk |
Likely pathogenic |
Charcot-Marie-Tooth disease type 4, Charcot-Marie-Tooth disease type 4C |
| RS750529492 |
FRAS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS750530263 |
SETX
|
Health Risk |
Conflicting classifications of pathogenicity |
Amyotrophic lateral sclerosis type 4, Spinocerebellar ataxia |
| RS750530407 |
ATP7B
|
Health Risk |
Conflicting classifications of pathogenicity |
Wilson disease, Wilson disease |
| RS750531364 |
PROS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Thrombophilia due to protein S deficiency, autosomal recessive |
| RS750531880 |
GLB1
|
Health Risk |
Pathogenic |
Mucopolysaccharidosis, MPS-IV-B |
| RS750532596 |
BLM
|
Health Risk |
Conflicting classifications of pathogenicity |
Bloom syndrome, Hereditary cancer-predisposing syndrome |
| RS75053309 |
CFTR
|
Health Risk |
Conflicting classifications of pathogenicity |
Cystic fibrosis, Cystic fibrosis |
| RS750534583 |
FANCD2
|
Health Risk |
Conflicting classifications of pathogenicity |
Fanconi anemia, Fanconi anemia complementation group D2 |
| RS750535100 |
UMOD
|
Health Risk |
Likely pathogenic |
— |
| RS750535468 |
FLCN
|
Health Risk |
Conflicting classifications of pathogenicity |
Birt-Hogg-Dube syndrome, Hereditary cancer-predisposing syndrome |
| RS75053547 |
ZNF341
|
Health Risk |
Conflicting classifications of pathogenicity |
ZNF341-related disorder, ZNF341-related disorder |
| RS750535638 |
OAT
|
Health Risk |
Pathogenic/Likely pathogenic |
Ornithine aminotransferase deficiency, Ornithine aminotransferase deficiency |
| RS750537710 |
SETX
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Amyotrophic lateral sclerosis type 4 |
| RS750538204 |
LAMB2
|
Health Risk |
Pathogenic |
Pierson syndrome, LAMB2-related infantile-onset nephrotic syndrome |
| RS750538499 |
COL4A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome, Brain small vessel disease 1 with or without ocular anomalies |
| RS750539322 |
NOTCH1
|
Health Risk |
Conflicting classifications of pathogenicity |
NOTCH1-related disorder, Adams-Oliver syndrome 5 |
| RS750539462 |
PDE6A
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinitis pigmentosa 43, Retinal dystrophy |
| RS750540944 |
DYNC2I1
|
Health Risk |
Pathogenic |
Short-rib thoracic dysplasia 8 with or without polydactyly, Short-rib thoracic dysplasia 8 with or without polydactyly |
| RS750542485 |
EXT2
|
Health Risk |
Pathogenic |
Exostoses, multiple |
| RS750542962 |
RP1
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinal dystrophy, Autosomal recessive retinitis pigmentosa |
| RS750543865 |
NDUFAF7
|
Health Risk |
Likely pathogenic |
— |
| RS750544827 |
SYNE1
|
Health Risk |
Pathogenic |
Autosomal recessive ataxia, Beauce type |
| RS750545429 |
PIEZO1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS750545562 |
GATA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Deafness-lymphedema-leukemia syndrome, Monocytopenia with susceptibility to infections |
| RS750545966 |
COPA
|
Health Risk |
Conflicting classifications of pathogenicity |
Autoimmune interstitial lung disease-arthritis syndrome, Inborn genetic diseases |
| RS750547223 |
WDR62
|
Health Risk |
Pathogenic |
— |
| RS750547893 |
SMARCA4
|
Health Risk |
Conflicting classifications of pathogenicity |
Rhabdoid tumor predisposition syndrome 2, Hereditary cancer-predisposing syndrome |
| RS750548251 |
WT1
|
Health Risk |
Conflicting classifications of pathogenicity |
Wilms tumor 1, 11p partial monosomy syndrome |
| RS750548324 |
MYLK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypertrophic cardiomyopathy 1, Hypertrophic cardiomyopathy 1 |
| RS750548522 |
PEPD
|
Health Risk |
Pathogenic/Likely pathogenic |
Prolidase deficiency, Megaconial type congenital muscular dystrophy |
| RS750548574 |
NEB
|
Health Risk |
Conflicting classifications of pathogenicity |
Nemaline myopathy 2, Arthrogryposis multiplex congenita 6 |
| RS750549000 |
FERRY3
|
Health Risk |
Pathogenic |
— |
| RS750549006 |
DMD
|
Health Risk |
Conflicting classifications of pathogenicity |
Duchenne muscular dystrophy, Dystrophin deficiency |
| RS750549499 |
STAR
|
Health Risk |
Pathogenic |
Congenital lipoid adrenal hyperplasia due to STAR deficency, Congenital lipoid adrenal hyperplasia due to STAR deficency |
| RS750550229 |
COL12A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Ullrich congenital muscular dystrophy 2, Bethlem myopathy 2 |
| RS750550558 |
PNKP
|
Health Risk |
Likely pathogenic |
— |
| RS750551012 |
RAD51C
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O |
| RS750551043 |
MYH3
|
Health Risk |
Conflicting classifications of pathogenicity |
Freeman-Sheldon syndrome, Distal arthrogryposis type 2B1 |
| RS750552137 |
AARS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Charcot-Marie-Tooth disease type 2, Inborn genetic diseases |
| RS750552324 |
NLRP12
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial cold autoinflammatory syndrome 2, Familial cold autoinflammatory syndrome 2 |
| RS750553908 |
TYR
|
Health Risk |
Pathogenic/Likely pathogenic |
SKIN/HAIR/EYE PIGMENTATION 3, LIGHT/DARK SKIN |
| RS750554079 |
COL4A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Alport syndrome, COL4A3-related disorder |
| RS750555513 |
ZNF423
|
Health Risk |
Conflicting classifications of pathogenicity |
Nephronophthisis 14, Nephronophthisis 14 |
| RS750556299 |
BRAF
|
Health Risk |
Conflicting classifications of pathogenicity |
RASopathy, 6 conditions |
| RS750556964 |
TMC6
|
Health Risk |
Conflicting classifications of pathogenicity |
Epidermodysplasia verruciformis, Inborn genetic diseases |
| RS750557604 |
DSP
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic right ventricular dysplasia 8, Arrhythmogenic cardiomyopathy with wooly hair and keratoderma |
| RS750558115 |
CFTR
|
Health Risk |
Pathogenic/Likely pathogenic |
Cystic fibrosis, CFTR-related disorder |
| RS750558686 |
SIK1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Developmental and epileptic encephalopathy |
| RS750559671 |
CFTR
|
Health Risk |
Pathogenic/Likely pathogenic |
Cystic fibrosis, Congenital bilateral aplasia of vas deferens from CFTR mutation |
| RS750559695 |
CYFIP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS750560040 |
TPRN
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS750560502 |
FLNB
|
Health Risk |
Conflicting classifications of pathogenicity |
FLNB-Related Spectrum Disorders, FLNB-Related Spectrum Disorders |
| RS750561477 |
FAT2
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS750562280 |
NIPBL
|
Health Risk |
Conflicting classifications of pathogenicity |
Cornelia de Lange syndrome 1, Cornelia de Lange syndrome 1 |
| RS750563193 |
MLH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary nonpolyposis colorectal neoplasms |
| RS750565190 |
EVC
|
Health Risk |
Likely pathogenic |
— |
| RS750565501 |
KMT2D
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Choanal atresia-athelia-hypothyroidism-delayed puberty-short stature syndrome |
| RS750565633 |
DNAH5
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS750566159 |
PNPO
|
Health Risk |
Conflicting classifications of pathogenicity |
Pyridoxal phosphate-responsive seizures, Pyridoxal phosphate-responsive seizures |
| RS750566714 |
SOX10
|
Health Risk |
Conflicting classifications of pathogenicity |
Waardenburg syndrome type 2E, Waardenburg syndrome type 2E |
| RS750567664 |
PYGL
|
Health Risk |
Pathogenic |
Glycogen storage disease, type VI |
| RS750568080 |
ADNP
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS750568866 |
SKIC3
|
Health Risk |
Pathogenic |
Trichohepatoenteric syndrome, Trichohepatoenteric syndrome |
| RS750569208 |
FANCB
|
Health Risk |
Conflicting classifications of pathogenicity |
Fanconi anemia, Fanconi anemia |
| RS750569823 |
IVD
|
Health Risk |
Conflicting classifications of pathogenicity |
Isovaleryl-CoA dehydrogenase deficiency, Inborn genetic diseases |
| RS750570683 |
JAG1
|
Health Risk |
Conflicting classifications of pathogenicity |
Alagille syndrome due to a JAG1 point mutation, Tetralogy of Fallot |
| RS750570850 |
MED13
|
Health Risk |
Pathogenic/Likely pathogenic |
Intellectual developmental disorder 61, See cases |
| RS750571210 |
OPTN
|
Health Risk |
Pathogenic |
Amyotrophic lateral sclerosis type 12, Primary open angle glaucoma |
| RS750571274 |
ZNF469
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Cardiovascular phenotype |
| RS750572947 |
PSTPIP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Pyogenic arthritis-pyoderma gangrenosum-acne syndrome, Autoinflammatory syndrome |
| RS750573078 |
MYO18B
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS750573655 |
LRP5
|
Health Risk |
Conflicting classifications of pathogenicity |
Osteogenesis imperfecta, Osteogenesis imperfecta |
| RS750573800 |
DACT1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS750573955 |
EIF2AK3
|
Health Risk |
Conflicting classifications of pathogenicity |
Connective tissue disorder, Connective tissue disorder |
| RS750577544 |
TNR
|
Health Risk |
Likely pathogenic |
Non-progressive neurodevelopmental disorder with spasticity and transient opisthotonus, Neurodevelopmental disorder |
| RS750578651 |
RB1
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinoblastoma, Retinoblastoma |
| RS750578677 |
MYO15A
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS750579270 |
DZIP1L
|
Health Risk |
Likely pathogenic |
— |
| RS750579288 |
SAMD9
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS750579775 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary nonpolyposis colorectal neoplasms |
| RS750580462 |
IL10RA
|
Health Risk |
Conflicting classifications of pathogenicity |
Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS750580632 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS750581150 |
BRCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer |
| RS750582198 |
COL4A5
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS750583669 |
MMUT
|
Health Risk |
Likely pathogenic |
Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency, Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency |
| RS750583721 |
HGSNAT
|
Health Risk |
Conflicting classifications of pathogenicity |
Mucopolysaccharidosis, MPS-III-C |
| RS750584489 |
VLDLR
|
Health Risk |
Pathogenic |
— |
| RS750585238 |
NEB
|
Health Risk |
Pathogenic/Likely pathogenic |
Nemaline myopathy 2, Nemaline myopathy 2 |
| RS750585255 |
PTEN
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, PTEN hamartoma tumor syndrome |
| RS750585884 |
ITK
|
Health Risk |
Conflicting classifications of pathogenicity |
Autoinflammatory syndrome, Lymphoproliferative syndrome 1 |
| RS750586158 |
RAD50
|
Health Risk |
Pathogenic/Likely pathogenic |
Hereditary cancer-predisposing syndrome, Nijmegen breakage syndrome-like disorder |
| RS750586210 |
ABCC8
|
Health Risk |
Pathogenic/Likely pathogenic |
Familial hyperinsulinism, Hereditary hyperinsulinism |
| RS750588859 |
PKHD1
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive polycystic kidney disease, PKHD1-related disorder |
| RS750590052 |
TRPM4
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive familial heart block type IB, Cardiovascular phenotype |
| RS750590533 |
SLC25A19
|
Health Risk |
Pathogenic |
Progressive demyelinating neuropathy with bilateral striatal necrosis, Progressive demyelinating neuropathy with bilateral striatal necrosis |
| RS750591887 |
ALMS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Alstrom syndrome, Cardiovascular phenotype |
| RS750591986 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive limb-girdle muscular dystrophy type 2J, Dilated cardiomyopathy 1G |
| RS750592118 |
KIAA0586
|
Health Risk |
Pathogenic |
Joubert syndrome 23, Short-rib thoracic dysplasia 14 with polydactyly |
| RS750592289 |
MUTYH
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 2 |