IL10RA Chromosome 11
Interleukin 10 receptor subunit alpha
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What This Gene Does
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Info
Gene Group
"CD molecules|Interleukin receptors"
Locus Type
gene with protein product
Location
11q23.3
Ensembl
ENSG00000110324
Associated Conditions (4)
Inflammatory bowel disease 28
Inborn genetic diseases
IL10RA-related disorder
Familial cancer of breast
Key Variants
RS117423374
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inflammatory bowel disease 28
Health Risk
RS1327527158
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inborn genetic diseases, Inflammatory bowel disease 28
Health Risk
RS138929400
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inflammatory bowel disease 28
Health Risk
RS139576148
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, IL10RA-related disorder, Inflammatory bowel disease 28
Health Risk
RS145949718
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inflammatory bowel disease 28
Health Risk
RS148808529
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inflammatory bowel disease 28
Health Risk
RS150551465
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inflammatory bowel disease 28
Health Risk
RS192749274
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inborn genetic diseases, Inflammatory bowel disease 28
Health Risk
RS199604463
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, IL10RA-related disorder, Inflammatory bowel disease 28
Health Risk
RS200992970
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inflammatory bowel disease 28
Health Risk
RS201396764
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inflammatory bowel disease 28
Health Risk
RS201643277
Conflicting classifications of pathogenicity
Inflammatory bowel disease 28, Inflammatory bowel disease 28
Health Risk
All Variants (47)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS117423374 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS1327527158 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inborn genetic diseases, Inflammatory bowel disease 28 |
| RS138929400 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS139576148 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, IL10RA-related disorder, Inflammatory bowel disease 28 |
| RS145949718 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS148808529 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS150551465 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS192749274 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inborn genetic diseases, Inflammatory bowel disease 28 |
| RS199604463 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, IL10RA-related disorder, Inflammatory bowel disease 28 |
| RS200992970 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS201396764 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS201643277 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS368287711 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, IL10RA-related disorder, Inflammatory bowel disease 28 |
| RS372372851 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS372503247 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inborn genetic diseases, Inflammatory bowel disease 28 |
| RS373278759 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inborn genetic diseases, Inflammatory bowel disease 28 |
| RS376629999 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inborn genetic diseases, Inflammatory bowel disease 28 |
| RS376956484 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS377525753 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS55721363 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS560128585 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS56143179 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS746663189 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS749622044 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS750580462 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS752519410 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS758480654 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Familial cancer of breast, Inflammatory bowel disease 28 |
| RS767275130 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS78753252 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS886047707 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS886047708 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS1192830343 | Health Risk | Likely pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS1414190221 | Health Risk | Likely pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS1027503096 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS1187971271 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS1214626558 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS137853579 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS137853580 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS1415553044 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS149491038 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS1591263883 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS2058036751 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS2134991615 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS2496780587 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS369219156 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS759537444 | Health Risk | Pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |
| RS1419560997 | Health Risk | Pathogenic/Likely pathogenic | Inflammatory bowel disease 28, Inflammatory bowel disease 28 |