ZNF341 Chromosome 20
Zinc finger protein 341
Upload your DNA to see your personal genotypes for variants in ZNF341.
What This Gene Does
Enables DNA binding activity and DNA-binding transcription activator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Implicated in hyper IgE recurrent infection syndrome 3. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Zinc fingers C2H2-type
Locus Type
gene with protein product
Location
20q11.22
Ensembl
ENSG00000131061
Associated Conditions (3)
Hyper-IgE recurrent infection syndrome 3
autosomal recessive
ZNF341-related disorder
Key Variants
RS138992523
Conflicting classifications of pathogenicity
Hyper-IgE recurrent infection syndrome 3, autosomal recessive, ZNF341-related disorder
Health Risk
RS143727353
Conflicting classifications of pathogenicity
Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3
Health Risk
RS370107539
Conflicting classifications of pathogenicity
Health Risk
RS75053547
Conflicting classifications of pathogenicity
ZNF341-related disorder, ZNF341-related disorder
Health Risk
RS754548303
Conflicting classifications of pathogenicity
Health Risk
RS759711668
Conflicting classifications of pathogenicity
Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3
Health Risk
RS774044758
Conflicting classifications of pathogenicity
Health Risk
RS1461028276
Likely pathogenic
Health Risk
RS2019198634
Likely pathogenic
Health Risk
RS2122686345
Likely pathogenic
Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3
Health Risk
RS748778102
Likely pathogenic
Health Risk
RS910498188
Likely pathogenic
Health Risk
All Variants (23)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS138992523 | Health Risk | Conflicting classifications of pathogenicity | Hyper-IgE recurrent infection syndrome 3, autosomal recessive, ZNF341-related disorder |
| RS143727353 | Health Risk | Conflicting classifications of pathogenicity | Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3 |
| RS370107539 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS75053547 | Health Risk | Conflicting classifications of pathogenicity | ZNF341-related disorder, ZNF341-related disorder |
| RS754548303 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS759711668 | Health Risk | Conflicting classifications of pathogenicity | Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3 |
| RS774044758 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1461028276 | Health Risk | Likely pathogenic | — |
| RS2019198634 | Health Risk | Likely pathogenic | — |
| RS2122686345 | Health Risk | Likely pathogenic | Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3 |
| RS748778102 | Health Risk | Likely pathogenic | — |
| RS910498188 | Health Risk | Likely pathogenic | — |
| RS1167242781 | Health Risk | Pathogenic | — |
| RS1385527728 | Health Risk | Pathogenic | — |
| RS1568940507 | Health Risk | Pathogenic | Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3 |
| RS1568945329 | Health Risk | Pathogenic | Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3 |
| RS2018787057 | Health Risk | Pathogenic | — |
| RS2122731441 | Health Risk | Pathogenic | — |
| RS2515458116 | Health Risk | Pathogenic | — |
| RS2515509700 | Health Risk | Pathogenic | — |
| RS376598954 | Health Risk | Pathogenic | Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3 |
| RS746141726 | Health Risk | Pathogenic | Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3 |
| RS982121798 | Health Risk | Pathogenic | Hyper-IgE recurrent infection syndrome 3, autosomal recessive, Hyper-IgE recurrent infection syndrome 3 |