| RS759584387 |
KCNQ2
|
Health Risk |
Likely pathogenic |
Seizures, benign familial neonatal |
| RS759584440 |
SOS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Fibromatosis, gingival |
| RS759584655 |
BCOR
|
Health Risk |
Conflicting classifications of pathogenicity |
Oculofaciocardiodental syndrome, Oculofaciocardiodental syndrome |
| RS759585425 |
CBL
|
Health Risk |
Conflicting classifications of pathogenicity |
RASopathy, Juvenile myelomonocytic leukemia |
| RS759585825 |
FKRP
|
Health Risk |
Conflicting classifications of pathogenicity |
Walker-Warburg congenital muscular dystrophy, Walker-Warburg congenital muscular dystrophy |
| RS759585885 |
GLI2
|
Health Risk |
Conflicting classifications of pathogenicity |
Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome, Holoprosencephaly 9 |
| RS759587265 |
WDR35
|
Health Risk |
Conflicting classifications of pathogenicity |
Cranioectodermal dysplasia 2, Short-rib thoracic dysplasia 7 with or without polydactyly |
| RS759589041 |
PRPF31
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinal dystrophy, Retinal disorder |
| RS759589301 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary nonpolyposis colorectal neoplasms |
| RS759589388 |
PDE6A
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinitis pigmentosa, Retinitis pigmentosa 43 |
| RS759589756 |
INF2
|
Health Risk |
Conflicting classifications of pathogenicity |
Focal segmental glomerulosclerosis 5, Charcot-Marie-Tooth disease dominant intermediate E |
| RS759590339 |
APOL1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS759590432 |
GALNS
|
Health Risk |
Conflicting classifications of pathogenicity |
Mucopolysaccharidosis, MPS-IV-A |
| RS759590778 |
FANCG
|
Health Risk |
Pathogenic/Likely pathogenic |
Fanconi anemia, Fanconi anemia complementation group G |
| RS759590811 |
ABCA12
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759591318 |
ALDH7A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Pyridoxine-dependent epilepsy, Pyridoxine-dependent epilepsy |
| RS759591544 |
COL4A4
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive Alport syndrome, Autosomal recessive Alport syndrome |
| RS759592382 |
DMD
|
Health Risk |
Conflicting classifications of pathogenicity |
Duchenne muscular dystrophy, Cardiomyopathy |
| RS759593186 |
TRPM4
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive familial heart block type IB, Cardiovascular phenotype |
| RS759593846 |
AHI1
|
Health Risk |
Pathogenic/Likely pathogenic |
Joubert syndrome, Joubert syndrome 3 |
| RS759594785 |
SEC24D
|
Health Risk |
Pathogenic |
Cole-Carpenter syndrome 2, Cole-Carpenter syndrome 2 |
| RS759595432 |
ADGRE2
|
Health Risk |
Conflicting classifications of pathogenicity |
Vibratory urticaria, Vibratory urticaria |
| RS759595738 |
RORB
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759597112 |
FLNC
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Hypertrophic cardiomyopathy 26 |
| RS759597531 |
SOX9
|
Health Risk |
Pathogenic |
CAMPOMELIC DYSPLASIA WITH AUTOSOMAL SEX REVERSAL, CAMPOMELIC DYSPLASIA WITH AUTOSOMAL SEX REVERSAL |
| RS759598033 |
CLN8
|
Health Risk |
Pathogenic |
Neuronal ceroid lipofuscinosis, Neuronal ceroid lipofuscinosis |
| RS759598868 |
PRPF8
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS759599321 |
TH
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive DOPA responsive dystonia, Autosomal recessive DOPA responsive dystonia |
| RS759600553 |
ACAD8
|
Health Risk |
Pathogenic |
Deficiency of isobutyryl-CoA dehydrogenase, Deficiency of isobutyryl-CoA dehydrogenase |
| RS759601398 |
BARD1
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS759603306 |
ALMS1
|
Health Risk |
Pathogenic |
Alstrom syndrome, Alstrom syndrome |
| RS759603316 |
TWNK
|
Health Risk |
Conflicting classifications of pathogenicity |
Perrault syndrome 5, Infantile onset spinocerebellar ataxia |
| RS759603724 |
DSG2
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic right ventricular dysplasia 10, Cardiovascular phenotype |
| RS759604491 |
TSFM
|
Health Risk |
Conflicting classifications of pathogenicity |
Fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3, Fatal mitochondrial disease due to combined oxidative phosphorylation defect type 3 |
| RS759606476 |
UBE2T
|
Health Risk |
Likely pathogenic |
— |
| RS759607901 |
POLH
|
Health Risk |
Pathogenic |
Xeroderma pigmentosum variant type, Xeroderma pigmentosum |
| RS759608783 |
CDH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary diffuse gastric adenocarcinoma |
| RS759610129 |
ABAT
|
Health Risk |
Conflicting classifications of pathogenicity |
Gamma-aminobutyric acid transaminase deficiency, Gamma-aminobutyric acid transaminase deficiency |
| RS759612018 |
CARD14
|
Health Risk |
Conflicting classifications of pathogenicity |
Psoriasis 2, Pityriasis rubra pilaris |
| RS759612790 |
IFT172
|
Health Risk |
Likely pathogenic |
Short-rib thoracic dysplasia 10 with or without polydactyly, Retinitis pigmentosa 71 |
| RS759613137 |
TXNRD2
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary dilated cardiomyopathy, Cardiovascular phenotype |
| RS75961395 |
CFTR
|
Health Risk |
Pathogenic |
Cystic fibrosis, Congenital bilateral aplasia of vas deferens from CFTR mutation |
| RS759614533 |
MMP20
|
Health Risk |
Likely pathogenic |
Amelogenesis imperfecta hypomaturation type 2A2, Amelogenesis imperfecta hypomaturation type 2A2 |
| RS759615683 |
HGD
|
Health Risk |
Conflicting classifications of pathogenicity |
Alkaptonuria, Alkaptonuria |
| RS759618368 |
CTNNA3
|
Health Risk |
Likely pathogenic |
Malignant tumor of urinary bladder, Malignant tumor of urinary bladder |
| RS759622308 |
CLCN6
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS759622893 |
BAP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, BAP1-related tumor predisposition syndrome |
| RS759623160 |
TET3
|
Health Risk |
Likely pathogenic |
Inborn genetic diseases, Beck-Fahrner syndrome |
| RS759623301 |
COL6A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Bethlem myopathy 1A, Bethlem myopathy 1A |
| RS759623627 |
TTN
|
Health Risk |
Likely pathogenic |
Dilated cardiomyopathy 1A, Dilated cardiomyopathy 1A |
| RS759623796 |
CTNS
|
Health Risk |
Pathogenic |
Nephropathic cystinosis, Ocular cystinosis |
| RS759624003 |
SGCA
|
Health Risk |
Likely pathogenic |
Autosomal recessive limb-girdle muscular dystrophy type 2D, Autosomal recessive limb-girdle muscular dystrophy type 2D |
| RS759624618 |
NEB
|
Health Risk |
Conflicting classifications of pathogenicity |
Nemaline myopathy 2, Nemaline myopathy 2 |
| RS759624749 |
FAM111A
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS759625169 |
EPG5
|
Health Risk |
Pathogenic |
Vici syndrome, Vici syndrome |
| RS759626368 |
LZTR1
|
Health Risk |
Pathogenic |
Cardiovascular phenotype, Hereditary cancer-predisposing syndrome |
| RS759627248 |
PIEZO1
|
Health Risk |
Conflicting classifications of pathogenicity |
PIEZO1-related disorder, PIEZO1-related disorder |
| RS759627305 |
COL5A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Ehlers-Danlos syndrome, classic type |
| RS759627672 |
IGHMBP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive distal spinal muscular atrophy 1, Charcot-Marie-Tooth disease axonal type 2S |
| RS759628921 |
CHD8
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759629466 |
BBS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Bardet-Biedl syndrome 2, Bardet-Biedl syndrome |
| RS759629535 |
KMT2D
|
Health Risk |
Pathogenic |
Kabuki syndrome 1, Kabuki syndrome 1 |
| RS759631057 |
COL4A4
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive Alport syndrome, X-linked Alport syndrome |
| RS759631551 |
L2HGDH
|
Health Risk |
Pathogenic |
L-2-hydroxyglutaric aciduria, L-2-hydroxyglutaric aciduria |
| RS759632048 |
PROP1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS759632330 |
FLNC
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Distal myopathy with posterior leg and anterior hand involvement |
| RS759632485 |
RYR1
|
Health Risk |
Pathogenic/Likely pathogenic |
RYR1-related disorder, Malignant hyperthermia |
| RS759632528 |
ASPM
|
Health Risk |
Pathogenic |
Microcephaly 5, primary |
| RS759632589 |
GBA2
|
Health Risk |
Pathogenic |
Hereditary spastic paraplegia 46, Spastic paraplegia |
| RS759632617 |
LTBP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Weill-Marchesani syndrome, Glaucoma 3 |
| RS759632995 |
HPS4
|
Health Risk |
Conflicting classifications of pathogenicity |
Hermansky-Pudlak syndrome 4, Hermansky-Pudlak syndrome 4 |
| RS759633494 |
GLB1
|
Health Risk |
Pathogenic/Likely pathogenic |
Mucopolysaccharidosis, MPS-IV-B |
| RS759633668 |
GABBR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Epileptic encephalopathy, Inborn genetic diseases |
| RS759634066 |
COL7A1
|
Health Risk |
Pathogenic/Likely pathogenic |
Recessive dystrophic epidermolysis bullosa, COL7A1-related disorder |
| RS759634111 |
ZNF469
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, ZNF469-related disorder |
| RS759636736 |
MTR
|
Health Risk |
Conflicting classifications of pathogenicity |
Disorders of Intracellular Cobalamin Metabolism, Methylcobalamin deficiency type cblG |
| RS759636773 |
B3GAT3
|
Health Risk |
Pathogenic |
Larsen-like syndrome, B3GAT3 type |
| RS759637055 |
FLCN
|
Health Risk |
Conflicting classifications of pathogenicity |
Birt-Hogg-Dube syndrome, Hereditary cancer-predisposing syndrome |
| RS759637817 |
NTRK1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary insensitivity to pain with anhidrosis, Inborn genetic diseases |
| RS759637818 |
RHO
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinal dystrophy, Retinal dystrophy |
| RS759638292 |
KDM1A
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759638923 |
SEMA4A
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS759639016 |
CDH2
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS759639526 |
IDUA
|
Health Risk |
Pathogenic |
Mucopolysaccharidosis type 1, Mucopolysaccharidosis type 1 |
| RS759639806 |
SAG
|
Health Risk |
Pathogenic |
— |
| RS759640087 |
RNF125
|
Health Risk |
Conflicting classifications of pathogenicity |
Tenorio syndrome, Inborn genetic diseases |
| RS759640649 |
ADAMTS17
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759641262 |
SMARCA4
|
Health Risk |
Conflicting classifications of pathogenicity |
Rhabdoid tumor predisposition syndrome 2, Hereditary cancer-predisposing syndrome |
| RS759641927 |
IGHMBP2
|
Health Risk |
Pathogenic/Likely pathogenic |
Charcot-Marie-Tooth disease axonal type 2S, Autosomal recessive distal spinal muscular atrophy 1 |
| RS759641985 |
HACE1
|
Health Risk |
Pathogenic/Likely pathogenic |
Spastic paraplegia-severe developmental delay-epilepsy syndrome, Spastic paraplegia-severe developmental delay-epilepsy syndrome |
| RS759642119 |
DMD
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Dystrophin deficiency |
| RS759642651 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS759643114 |
BPTF
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759643427 |
BCHE
|
Health Risk |
Pathogenic/Likely pathogenic |
Deficiency of butyrylcholinesterase, Deficiency of butyrylcholinesterase |
| RS759643679 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Lynch syndrome |
| RS759643831 |
NOTCH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Adams-Oliver syndrome 5, NOTCH1-related disorder |
| RS759644676 |
SPEG
|
Health Risk |
Pathogenic |
Myopathy, centronuclear |
| RS759644973 |
COL7A1
|
Health Risk |
Pathogenic/Likely pathogenic |
Epidermolysis bullosa dystrophica, 7 conditions |
| RS759644974 |
CDH23
|
Health Risk |
Likely pathogenic |
— |
| RS759646195 |
ITCH
|
Health Risk |
Conflicting classifications of pathogenicity |
Syndromic multisystem autoimmune disease due to ITCH deficiency, Colorectal cancer |