| RS759453664 |
PIGN
|
Health Risk |
Likely pathogenic |
Multiple congenital anomalies-hypotonia-seizures syndrome 1, Multiple congenital anomalies-hypotonia-seizures syndrome 1 |
| RS759454598 |
SLC25A15
|
Health Risk |
Likely pathogenic |
— |
| RS759455097 |
COL4A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Alport syndrome, Autosomal dominant Alport syndrome |
| RS759455327 |
BBS12
|
Health Risk |
Pathogenic |
Bardet-Biedl syndrome, Bardet-Biedl syndrome 12 |
| RS759455445 |
COL7A1
|
Health Risk |
Pathogenic |
Epidermolysis bullosa dystrophica, Epidermolysis bullosa dystrophica |
| RS759455459 |
COL11A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759456303 |
NOD2
|
Health Risk |
Conflicting classifications of pathogenicity |
Autoinflammatory syndrome, Blau syndrome |
| RS759456867 |
NOTCH2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hajdu-Cheney syndrome, Hajdu-Cheney syndrome |
| RS759457950 |
VCAN
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759458296 |
SCN10A
|
Health Risk |
Conflicting classifications of pathogenicity |
Brugada syndrome, Cardiovascular phenotype |
| RS759458391 |
TNNT1
|
Health Risk |
Pathogenic |
Nemaline myopathy 5B, autosomal recessive |
| RS759460647 |
COL9A1
|
Health Risk |
Likely pathogenic |
COL9A1-related disorder, COL9A1-related disorder |
| RS759460806 |
SYNE1
|
Health Risk |
Pathogenic/Likely pathogenic |
Emery-Dreifuss muscular dystrophy 4, autosomal dominant |
| RS759461234 |
EDARADD
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypohidrotic ectodermal dysplasia, Inborn genetic diseases |
| RS759461742 |
DYSF
|
Health Risk |
Conflicting classifications of pathogenicity |
Neuromuscular disease caused by qualitative or quantitative defects of dysferlin, Inborn genetic diseases |
| RS759462215 |
ITGA2B
|
Health Risk |
Conflicting classifications of pathogenicity |
Glanzmann thrombasthenia, Glanzmann thrombasthenia |
| RS75946332 |
ALB
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759464073 |
COL5A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Ehlers-Danlos syndrome, classic type |
| RS759464364 |
ACAD9
|
Health Risk |
Likely pathogenic |
Acyl-CoA dehydrogenase 9 deficiency, Acyl-CoA dehydrogenase 9 deficiency |
| RS759465116 |
NF1
|
Health Risk |
Conflicting classifications of pathogenicity |
Neurofibromatosis, type 1 |
| RS759465865 |
RB1
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinoblastoma, Hereditary cancer-predisposing syndrome |
| RS759466766 |
PPP1R15B
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS759466798 |
CC2D2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Meckel-Gruber syndrome, Joubert syndrome |
| RS759468315 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1G, Autosomal recessive limb-girdle muscular dystrophy type 2J |
| RS759468353 |
OFD1
|
Health Risk |
Conflicting classifications of pathogenicity |
Orofaciodigital syndrome I, Joubert syndrome |
| RS759468399 |
SMAD6
|
Health Risk |
Conflicting classifications of pathogenicity |
Aortic valve disease 2, Inborn genetic diseases |
| RS759468416 |
CCDC40
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia 15, Usher syndrome |
| RS759468738 |
SETX
|
Health Risk |
Conflicting classifications of pathogenicity |
Amyotrophic lateral sclerosis type 4, Spinocerebellar ataxia |
| RS759468742 |
PINK1
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive early-onset Parkinson disease 6, Autosomal recessive early-onset Parkinson disease 6 |
| RS759468937 |
CACNA1C
|
Health Risk |
Conflicting classifications of pathogenicity |
Long QT syndrome, Cardiovascular phenotype |
| RS759469907 |
FLVCR2
|
Health Risk |
Pathogenic |
— |
| RS759471464 |
PCDH15
|
Health Risk |
Conflicting classifications of pathogenicity |
Usher syndrome type 1, Usher syndrome type 1 |
| RS759472256 |
KIF5A
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary spastic paraplegia 10, Spastic paraplegia |
| RS759472787 |
SDHAF2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary pheochromocytoma and paraganglioma, Hereditary cancer-predisposing syndrome |
| RS759473511 |
CRELD1
|
Health Risk |
Conflicting classifications of pathogenicity |
CRELD1-related disorder, Atrioventricular septal defect |
| RS759473833 |
STK11
|
Health Risk |
Conflicting classifications of pathogenicity |
Peutz-Jeghers syndrome, Hereditary cancer-predisposing syndrome |
| RS759473851 |
NDUFS6
|
Health Risk |
Pathogenic/Likely pathogenic |
Inborn genetic diseases, Mitochondrial complex I deficiency |
| RS759474127 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS759474251 |
KBTBD13
|
Health Risk |
Conflicting classifications of pathogenicity |
Nemaline myopathy 6, Inborn genetic diseases |
| RS759477389 |
COL1A2
|
Health Risk |
Conflicting classifications of pathogenicity |
Osteogenesis imperfecta type I, Ehlers-Danlos syndrome |
| RS759477396 |
RMND1
|
Health Risk |
Pathogenic |
Combined oxidative phosphorylation defect type 11, Combined oxidative phosphorylation defect type 11 |
| RS759479262 |
KAT6B
|
Health Risk |
Conflicting classifications of pathogenicity |
Genitopatellar syndrome, Inborn genetic diseases |
| RS75948012 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1G, Autosomal recessive limb-girdle muscular dystrophy type 2J |
| RS759481997 |
TPM1
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiomyopathy, Cardiovascular phenotype |
| RS759483184 |
GLB1
|
Health Risk |
Conflicting classifications of pathogenicity |
GM1 gangliosidosis, Mucopolysaccharidosis |
| RS759483250 |
UNG
|
Health Risk |
Pathogenic |
Hyper-IgM syndrome type 5, Hyper-IgM syndrome type 5 |
| RS759483921 |
ASS1
|
Health Risk |
Pathogenic/Likely pathogenic |
Citrullinemia, Citrullinemia type I |
| RS759484732 |
ALOX12B
|
Health Risk |
Likely pathogenic |
Autosomal recessive congenital ichthyosis 2, Autosomal recessive congenital ichthyosis 2 |
| RS759484932 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive limb-girdle muscular dystrophy type 2J, Dilated cardiomyopathy 1G |
| RS759485449 |
ASPM
|
Health Risk |
Pathogenic |
Microcephaly 5, primary |
| RS759486889 |
ELANE
|
Health Risk |
Conflicting classifications of pathogenicity |
Cyclical neutropenia, Neutropenia |
| RS759487287 |
KCNJ11
|
Health Risk |
Conflicting classifications of pathogenicity |
Permanent neonatal diabetes mellitus, Maturity-onset diabetes of the young |
| RS759487846 |
DYSF
|
Health Risk |
Conflicting classifications of pathogenicity |
Neuromuscular disease caused by qualitative or quantitative defects of dysferlin, Inborn genetic diseases |
| RS759488854 |
RAPSN
|
Health Risk |
Pathogenic/Likely pathogenic |
Congenital myasthenic syndrome 11, Fetal akinesia deformation sequence 1 |
| RS759489151 |
EXOC7
|
Health Risk |
Pathogenic |
Neurodevelopmental disorder with seizures and brain atrophy, Neurodevelopmental disorder with seizures and brain atrophy |
| RS75949023 |
LOXHD1
|
Health Risk |
Pathogenic/Likely pathogenic |
Autosomal recessive nonsyndromic hearing loss 77, Rare genetic deafness |
| RS759490631 |
TERT
|
Health Risk |
Conflicting classifications of pathogenicity |
Dyskeratosis congenita, autosomal dominant 2 |
| RS759493134 |
SCARB2
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive myoclonic epilepsy, Inborn genetic diseases |
| RS759493890 |
PTCH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Gorlin syndrome, Hereditary cancer-predisposing syndrome |
| RS759494098 |
RYR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiomyopathy, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS759494205 |
USH2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Usher syndrome type 2A, Retinitis pigmentosa 39 |
| RS759494825 |
FBN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial thoracic aortic aneurysm and aortic dissection, Marfan syndrome |
| RS759496973 |
TRNT1
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome, Congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome |
| RS759497776 |
CREBBP
|
Health Risk |
Conflicting classifications of pathogenicity |
Rubinstein-Taybi syndrome, Rubinstein-Taybi syndrome |
| RS759500388 |
DVL1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759500860 |
CLPB
|
Health Risk |
Pathogenic |
3-methylglutaconic aciduria, type VIIB |
| RS759501468 |
RELN
|
Health Risk |
Conflicting classifications of pathogenicity |
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7 |
| RS759501511 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary nonpolyposis colorectal neoplasms |
| RS759501764 |
DDX41
|
Health Risk |
Pathogenic |
Inborn genetic diseases, Inborn genetic diseases |
| RS759503727 |
FRMPD4
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759505367 |
B3GLCT
|
Health Risk |
Pathogenic |
Peters plus syndrome, Peters plus syndrome |
| RS759505522 |
SPTBN2
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS759505780 |
RLBP1
|
Health Risk |
Pathogenic/Likely pathogenic |
Newfoundland cone-rod dystrophy, Pigmentary retinal dystrophy |
| RS759507153 |
OCLN
|
Health Risk |
Pathogenic |
Pseudo-TORCH syndrome 1, Pseudo-TORCH syndrome 1 |
| RS759509150 |
RNF43
|
Health Risk |
Conflicting classifications of pathogenicity |
Sessile serrated polyposis cancer syndrome, Sessile serrated polyposis cancer syndrome |
| RS759509443 |
LAMC2
|
Health Risk |
Likely pathogenic |
Junctional epidermolysis bullosa gravis of Herlitz, Epidermolysis bullosa |
| RS759510649 |
KMT2D
|
Health Risk |
Conflicting classifications of pathogenicity |
Kabuki syndrome, Kabuki syndrome 1 |
| RS759510890 |
LRP5
|
Health Risk |
Conflicting classifications of pathogenicity |
6 conditions, 6 conditions |
| RS759511006 |
GALC
|
Health Risk |
Likely pathogenic |
Galactosylceramide beta-galactosidase deficiency, Melanoma |
| RS759511516 |
SKIC2
|
Health Risk |
Pathogenic/Likely pathogenic |
Trichohepatoenteric syndrome 2, Trichohepatoenteric syndrome |
| RS759512115 |
COL4A5
|
Health Risk |
Pathogenic |
X-linked Alport syndrome, X-linked Alport syndrome |
| RS759512176 |
EHMT1
|
Health Risk |
Conflicting classifications of pathogenicity |
Kleefstra syndrome 1, Inborn genetic diseases |
| RS759512847 |
TTR
|
Health Risk |
Conflicting classifications of pathogenicity |
Amyloidosis, hereditary systemic 1 |
| RS759513613 |
ABCA4
|
Health Risk |
Likely pathogenic |
Retinal dystrophy, Retinal dystrophy |
| RS759513930 |
PMM2
|
Health Risk |
Pathogenic/Likely pathogenic |
PMM2-congenital disorder of glycosylation, PMM2-related disorder |
| RS759513934 |
DSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic right ventricular dysplasia 11, Cardiomyopathy |
| RS759515663 |
GALC
|
Health Risk |
Likely pathogenic |
— |
| RS759516161 |
DSP
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic cardiomyopathy with wooly hair and keratoderma, Arrhythmogenic right ventricular dysplasia 8 |
| RS759516529 |
LAMA2
|
Health Risk |
Pathogenic |
— |
| RS759517614 |
DRP2
|
Health Risk |
Pathogenic |
Charcot-Marie-Tooth disease, Charcot-Marie-Tooth disease |
| RS759518184 |
LAMB3
|
Health Risk |
Pathogenic |
Junctional epidermolysis bullosa gravis of Herlitz, Junctional epidermolysis bullosa |
| RS759518659 |
GAA
|
Health Risk |
Likely pathogenic |
Glycogen storage disease, type II |
| RS759518981 |
TRPM4
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive familial heart block type IB, Cardiovascular phenotype |
| RS759520211 |
BBS4
|
Health Risk |
Likely pathogenic |
Bardet-Biedl syndrome, Bardet-Biedl syndrome 4 |
| RS759520465 |
ATM
|
Health Risk |
Likely pathogenic |
Hereditary cancer-predisposing syndrome, Ataxia-telangiectasia syndrome |
| RS759520580 |
TSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Tuberous sclerosis syndrome |
| RS759520915 |
BMPR1A
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Generalized juvenile polyposis/juvenile polyposis coli |
| RS759520932 |
MYH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypertrophic cardiomyopathy 14, Dilated cardiomyopathy 1EE |
| RS759521447 |
PHF21A
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism with or without seizures, Inborn genetic diseases |
| RS759522148 |
MET
|
Health Risk |
Conflicting classifications of pathogenicity |
Renal cell carcinoma, Hereditary cancer-predisposing syndrome |