| RS747379649 |
SIX1
|
Health Risk |
Conflicting classifications of pathogenicity |
Branchiootic syndrome 3, Autosomal dominant nonsyndromic hearing loss 23 |
| RS747379918 |
MAT2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial thoracic aortic aneurysm and aortic dissection, Familial thoracic aortic aneurysm and aortic dissection |
| RS747380313 |
KRIT1
|
Health Risk |
Pathogenic |
Cerebral cavernous malformation, Cerebral cavernous malformation |
| RS747380397 |
PRF1
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial hemophagocytic lymphohistiocytosis 2, Autoinflammatory syndrome |
| RS747381671 |
FKBP14
|
Health Risk |
Conflicting classifications of pathogenicity |
Ehlers-Danlos syndrome, kyphoscoliotic type |
| RS747382969 |
NF1
|
Health Risk |
Pathogenic |
Neurofibromatosis, type 1 |
| RS747383685 |
PDCD10
|
Health Risk |
Pathogenic |
Cerebral cavernous malformation 3, Cerebral cavernous malformation 3 |
| RS747383768 |
SLC12A3
|
Health Risk |
Pathogenic/Likely pathogenic |
Familial hypokalemia-hypomagnesemia, Familial hypokalemia-hypomagnesemia |
| RS747384273 |
CBS
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial thoracic aortic aneurysm and aortic dissection, HYPERHOMOCYSTEINEMIA |
| RS747385238 |
PIEZO1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS747385350 |
PTCH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Gorlin syndrome |
| RS747386514 |
COL4A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Alport syndrome, Alport syndrome |
| RS747386965 |
ABCC6
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive inherited pseudoxanthoma elasticum, Arterial calcification |
| RS747387614 |
RBM20
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1DD, Dilated cardiomyopathy 1DD |
| RS747387987 |
BRCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS747388658 |
BBS9
|
Health Risk |
Pathogenic |
Bardet-Biedl syndrome, Bardet-Biedl syndrome 9 |
| RS747388850 |
RYR1
|
Health Risk |
Conflicting classifications of pathogenicity |
RYR1-related disorder, RYR1-related disorder |
| RS747389157 |
KAT6A
|
Health Risk |
Conflicting classifications of pathogenicity |
KAT6A-related disorder, Autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome |
| RS747389406 |
NNT
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS747390615 |
UNC13D
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial hemophagocytic lymphohistiocytosis 3, Autoinflammatory syndrome |
| RS747390978 |
ANK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Long QT syndrome, Cardiovascular phenotype |
| RS747391373 |
SACS
|
Health Risk |
Conflicting classifications of pathogenicity |
Spastic paraplegia, Inborn genetic diseases |
| RS747391554 |
PI4KA
|
Health Risk |
Pathogenic |
Polymicrogyria, perisylvian |
| RS747392139 |
MYH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial thoracic aortic aneurysm and aortic dissection, Aortic aneurysm |
| RS747393487 |
RPE65
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinitis pigmentosa 20, Leber congenital amaurosis 2 |
| RS747395624 |
OCA2
|
Health Risk |
Pathogenic |
Tyrosinase-positive oculocutaneous albinism, SKIN/HAIR/EYE PIGMENTATION 1 |
| RS747396791 |
OCRL
|
Health Risk |
Conflicting classifications of pathogenicity |
Lowe syndrome, Lowe syndrome |
| RS747399274 |
TREX1
|
Health Risk |
Pathogenic |
Aicardi-Goutieres syndrome 1, Chilblain lupus 1 |
| RS747400412 |
LRPPRC
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS747400815 |
ACTN2
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1AA, Primary familial hypertrophic cardiomyopathy |
| RS747401094 |
CIT
|
Health Risk |
Conflicting classifications of pathogenicity |
Microcephaly 17, primary |
| RS747402972 |
ABCC8
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary hyperinsulinism, Transitory neonatal diabetes mellitus |
| RS747402973 |
RFXANK
|
Health Risk |
Pathogenic |
MHC class II deficiency, MHC class II deficiency 2 |
| RS74740314 |
CHD6
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS747403932 |
NDUFB3
|
Health Risk |
Likely pathogenic |
— |
| RS747405574 |
UMPS
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary orotic aciduria, Hereditary orotic aciduria |
| RS747406535 |
RAD51C
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS747406932 |
BRCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary breast ovarian cancer syndrome, Hereditary cancer-predisposing syndrome |
| RS747407654 |
RYR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Catecholaminergic polymorphic ventricular tachycardia 1, Cardiomyopathy |
| RS747407725 |
NDUFV1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS747408689 |
OCA2
|
Health Risk |
Pathogenic/Likely pathogenic |
SKIN/HAIR/EYE PIGMENTATION 1, BLUE/NONBLUE EYES |
| RS747409134 |
BCOR
|
Health Risk |
Conflicting classifications of pathogenicity |
Oculofaciocardiodental syndrome, Oculofaciocardiodental syndrome |
| RS747409403 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Early-onset myopathy with fatal cardiomyopathy, Tibial muscular dystrophy |
| RS747409509 |
LAMB1
|
Health Risk |
Conflicting classifications of pathogenicity |
Cobblestone lissencephaly without muscular or ocular involvement, Cobblestone lissencephaly without muscular or ocular involvement |
| RS747409654 |
RYR1
|
Health Risk |
Likely pathogenic |
— |
| RS747409671 |
GARS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Charcot-Marie-Tooth disease type 2, Charcot-Marie-Tooth disease type 2 |
| RS747410628 |
SLC2A9
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypouricemia, renal |
| RS747410893 |
COL12A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Ullrich congenital muscular dystrophy 2, Bethlem myopathy 2 |
| RS747412555 |
LINS1
|
Health Risk |
Likely pathogenic |
Intellectual disability, autosomal recessive 27 |
| RS747413278 |
CACNA1A
|
Health Risk |
Conflicting classifications of pathogenicity |
Episodic ataxia type 2, Developmental and epileptic encephalopathy |
| RS747417254 |
TAPBP
|
Health Risk |
Conflicting classifications of pathogenicity |
MHC class I deficiency, MHC class I deficiency |
| RS747417629 |
CUBN
|
Health Risk |
Pathogenic |
Imerslund-Grasbeck syndrome, Imerslund-Grasbeck syndrome |
| RS747418024 |
PLEKHG5
|
Health Risk |
Conflicting classifications of pathogenicity |
Neuronopathy, distal hereditary motor |
| RS747418061 |
APC
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Classic or attenuated familial adenomatous polyposis |
| RS747418290 |
BRCA2
|
Health Risk |
Pathogenic |
Breast-ovarian cancer, familial |
| RS747418653 |
PIGO
|
Health Risk |
Conflicting classifications of pathogenicity |
Hyperphosphatasia with intellectual disability syndrome 2, Hyperphosphatasia with intellectual disability syndrome 2 |
| RS747419192 |
COL3A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Ehlers-Danlos syndrome, type 4 |
| RS747419302 |
RSPH4A
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia 11 |
| RS747419767 |
CBS
|
Health Risk |
Conflicting classifications of pathogenicity |
Classic homocystinuria, HYPERHOMOCYSTEINEMIA |
| RS747419878 |
COL6A1
|
Health Risk |
Pathogenic |
Bethlem myopathy 1A, Bethlem myopathy 1A |
| RS747420910 |
TSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Tuberous sclerosis 2, Hereditary cancer-predisposing syndrome |
| RS747423090 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive limb-girdle muscular dystrophy type 2J, Dilated cardiomyopathy 1G |
| RS747423578 |
NEB
|
Health Risk |
Conflicting classifications of pathogenicity |
Nemaline myopathy 2, Inborn genetic diseases |
| RS747424133 |
DSC2
|
Health Risk |
Likely pathogenic |
Arrhythmogenic right ventricular dysplasia 11, Cardiomyopathy |
| RS747424547 |
KIF1C
|
Health Risk |
Conflicting classifications of pathogenicity |
Spastic ataxia 2, Inborn genetic diseases |
| RS747425038 |
NEB
|
Health Risk |
Conflicting classifications of pathogenicity |
Nemaline myopathy 2, Nemaline myopathy 2 |
| RS747425652 |
CDHR1
|
Health Risk |
Pathogenic |
Retinitis pigmentosa 65, Retinal dystrophy |
| RS747426357 |
CACNA1H
|
Health Risk |
Conflicting classifications of pathogenicity |
Idiopathic generalized epilepsy, Hyperaldosteronism |
| RS747426363 |
DNAH3
|
Health Risk |
Likely pathogenic |
Spermatogenic failure 18, Spermatogenic failure 18 |
| RS747427445 |
BMP6
|
Health Risk |
Likely pathogenic |
Premature ovarian failure, Premature ovarian failure |
| RS7474275 |
BTK
|
Health Risk |
Likely pathogenic |
— |
| RS747427602 |
PRKN
|
Health Risk |
Pathogenic/Likely pathogenic |
Autosomal recessive juvenile Parkinson disease 2, Ovarian cancer |
| RS747428323 |
UNC13D
|
Health Risk |
Conflicting classifications of pathogenicity |
Autoinflammatory syndrome, Familial hemophagocytic lymphohistiocytosis 3 |
| RS747429748 |
ATP8B1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS747430075 |
LZTR1
|
Health Risk |
Pathogenic |
LZTR1-related schwannomatosis, Noonan syndrome 10 |
| RS747430905 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Early-onset myopathy with fatal cardiomyopathy, Dilated cardiomyopathy 1G |
| RS747431164 |
AARS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Charcot-Marie-Tooth disease type 2, Charcot-Marie-Tooth disease axonal type 2N |
| RS747431211 |
EP300
|
Health Risk |
Conflicting classifications of pathogenicity |
EP300-related disorder, Rubinstein-Taybi syndrome due to EP300 haploinsufficiency |
| RS747431847 |
CTRC
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary pancreatitis, Hereditary pancreatitis |
| RS747433688 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Cardiovascular phenotype |
| RS747434152 |
RYR1
|
Health Risk |
Conflicting classifications of pathogenicity |
RYR1-related disorder, Malignant hyperthermia |
| RS747434741 |
AARS1
|
Health Risk |
Pathogenic |
Charcot-Marie-Tooth disease type 2, Charcot-Marie-Tooth disease type 2 |
| RS747435524 |
BRF1
|
Health Risk |
Pathogenic |
See cases, See cases |
| RS747437028 |
GFM1
|
Health Risk |
Likely pathogenic |
Malignant tumor of urinary bladder, Malignant tumor of urinary bladder |
| RS747437062 |
ANKRD11
|
Health Risk |
Pathogenic |
— |
| RS747437391 |
ATP8B1
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive familial intrahepatic cholestasis type 1, Progressive familial intrahepatic cholestasis type 1 |
| RS747437399 |
CSF3R
|
Health Risk |
Pathogenic |
Autosomal recessive severe congenital neutropenia due to CSF3R deficiency, Autosomal recessive severe congenital neutropenia due to CSF3R deficiency |
| RS747437716 |
BMPR1A
|
Health Risk |
Conflicting classifications of pathogenicity |
Juvenile polyposis syndrome, Hereditary cancer-predisposing syndrome |
| RS747438350 |
ASPA
|
Health Risk |
Likely pathogenic |
Spongy degeneration of central nervous system, Spongy degeneration of central nervous system |
| RS747438636 |
ARID1B
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, ARID1B-related disorder |
| RS747441460 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS747442701 |
NDUFS6
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS747442861 |
DNAH11
|
Health Risk |
Pathogenic/Likely pathogenic |
Primary ciliary dyskinesia, Primary ciliary dyskinesia 7 |
| RS747444881 |
ZSWIM6
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS747445236 |
ATM
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Ataxia-telangiectasia syndrome |
| RS747445357 |
RECQL4
|
Health Risk |
Conflicting classifications of pathogenicity |
Baller-Gerold syndrome, Rothmund-Thomson syndrome type 2 |
| RS747445534 |
NBEA
|
Health Risk |
Conflicting classifications of pathogenicity |
Neurodevelopmental disorder with or without early-onset generalized epilepsy, Neurodevelopmental disorder with or without early-onset generalized epilepsy |
| RS747446711 |
BARD1
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS747446924 |
COL2A1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS747447519 |
CNGA3
|
Health Risk |
Pathogenic/Likely pathogenic |
Achromatopsia 2, CNGA3-related disorder |