LINS1 Chromosome 15
Lines homolog 1
Upload your DNA to see your personal genotypes for variants in LINS1.
What This Gene Does
The Drosophila segment polarity gene lin encodes a protein, lines, which plays important roles in development of the epidermis and hindgut. This gene encodes a protein containing a lines-like domain. This gene is located on chromosome 15 and clustered with the gene encoding ankyrin repeat and SOCS box-containing protein 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]
Associated Conditions (4)
Intellectual disability
autosomal recessive 27
Inborn genetic diseases
LINS1-related disorder
Key Variants
RS140140023
Conflicting classifications of pathogenicity
Intellectual disability, autosomal recessive 27, Inborn genetic diseases
Health Risk
RS141782332
Conflicting classifications of pathogenicity
Inborn genetic diseases, LINS1-related disorder, Inborn genetic diseases
Health Risk
RS146704559
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS150280970
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS150317593
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS150348863
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS150775570
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS2505320840
Conflicting classifications of pathogenicity
Health Risk
RS760477654
Conflicting classifications of pathogenicity
Intellectual disability, autosomal recessive 27, Intellectual disability
Health Risk
RS764442764
Conflicting classifications of pathogenicity
Intellectual disability, autosomal recessive 27, Intellectual disability
Health Risk
RS772619184
Conflicting classifications of pathogenicity
Health Risk
RS1057519019
Likely pathogenic
Intellectual disability, autosomal recessive 27, Intellectual disability
Health Risk
All Variants (35)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS140140023 | Health Risk | Conflicting classifications of pathogenicity | Intellectual disability, autosomal recessive 27, Inborn genetic diseases |
| RS141782332 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, LINS1-related disorder, Inborn genetic diseases |
| RS146704559 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS150280970 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS150317593 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS150348863 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS150775570 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS2505320840 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS760477654 | Health Risk | Conflicting classifications of pathogenicity | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS764442764 | Health Risk | Conflicting classifications of pathogenicity | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS772619184 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1057519019 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS1163046936 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS1198074890 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS1261920708 | Health Risk | Likely pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS1375900032 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS1834650809 | Health Risk | Likely pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS2038074697 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS2141261531 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS2141262985 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS2141270241 | Health Risk | Likely pathogenic | — |
| RS2505319687 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS2505377753 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS2549193603 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS747412555 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS767760664 | Health Risk | Likely pathogenic | — |
| RS768006727 | Health Risk | Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS869312932 | Health Risk | Likely pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS1131691716 | Health Risk | Pathogenic | — |
| RS1596890522 | Health Risk | Pathogenic | — |
| RS1596891223 | Health Risk | Pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS587777225 | Health Risk | Pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS587777226 | Health Risk | Pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |
| RS755894515 | Health Risk | Pathogenic | — |
| RS149644940 | Health Risk | Pathogenic/Likely pathogenic | Intellectual disability, autosomal recessive 27, Intellectual disability |