| RS764210489 |
COL2A1
|
Health Risk |
Pathogenic |
— |
| RS764210532 |
POMT2
|
Health Risk |
Pathogenic |
Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2 |
| RS764210725 |
NOTCH2
|
Health Risk |
Conflicting classifications of pathogenicity |
Alagille syndrome due to a NOTCH2 point mutation, Hajdu-Cheney syndrome |
| RS764211125 |
P4HA2
|
Health Risk |
Pathogenic |
Myopia 25, autosomal dominant |
| RS764211494 |
WFS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant nonsyndromic hearing loss 6, Cataract 41 |
| RS764212214 |
CACNA1C
|
Health Risk |
Conflicting classifications of pathogenicity |
Long QT syndrome, Cardiovascular phenotype |
| RS764213364 |
MCCC2
|
Health Risk |
Pathogenic |
3-methylcrotonyl-CoA carboxylase 2 deficiency, 3-methylcrotonyl-CoA carboxylase 2 deficiency |
| RS764213589 |
MET
|
Health Risk |
Conflicting classifications of pathogenicity |
Renal cell carcinoma, Hereditary cancer-predisposing syndrome |
| RS764214258 |
PDGFRA
|
Health Risk |
Conflicting classifications of pathogenicity |
Gastrointestinal stromal tumor, Hereditary cancer-predisposing syndrome |
| RS764215221 |
SUMF1
|
Health Risk |
Conflicting classifications of pathogenicity |
Multiple sulfatase deficiency, Multiple sulfatase deficiency |
| RS764216969 |
PKHD1
|
Health Risk |
Pathogenic |
Autosomal recessive polycystic kidney disease, Autosomal recessive polycystic kidney disease |
| RS764217666 |
SLC4A11
|
Health Risk |
Pathogenic |
Corneal dystrophy-perceptive deafness syndrome, Congenital hereditary endothelial dystrophy of cornea |
| RS764218079 |
TSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Tuberous sclerosis 2, Hereditary cancer-predisposing syndrome |
| RS764218640 |
FBN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Marfan syndrome, Familial thoracic aortic aneurysm and aortic dissection |
| RS764219842 |
SLC27A4
|
Health Risk |
Pathogenic |
Ichthyosis prematurity syndrome, Ichthyosis prematurity syndrome |
| RS764220175 |
SLC12A3
|
Health Risk |
Likely pathogenic |
— |
| RS764220516 |
PHOX2B
|
Health Risk |
Conflicting classifications of pathogenicity |
Haddad syndrome, Haddad syndrome |
| RS764220674 |
ABCB11
|
Health Risk |
Conflicting classifications of pathogenicity |
ABCB11-related disorder, Inborn genetic diseases |
| RS764220898 |
SERPINA1
|
Health Risk |
Likely pathogenic |
Alpha-1-antitrypsin deficiency, Alpha-1-antitrypsin deficiency |
| RS764221630 |
SCN2B
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Atrial fibrillation |
| RS764222986 |
IFT122
|
Health Risk |
Pathogenic |
Cranioectodermal dysplasia 1, Cranioectodermal dysplasia 1 |
| RS764224799 |
HOGA1
|
Health Risk |
Likely pathogenic |
Primary hyperoxaluria type 3, Primary hyperoxaluria type 3 |
| RS764225649 |
VPS13B
|
Health Risk |
Likely pathogenic |
Cohen syndrome, Cohen syndrome |
| RS764225717 |
TSC2
|
Health Risk |
Pathogenic |
— |
| RS764225803 |
COL6A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Bethlem myopathy 1A, Bethlem myopathy 1A |
| RS764226133 |
MKRN3
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS764227040 |
PEX6
|
Health Risk |
Pathogenic |
Peroxisome biogenesis disorder, Zellweger spectrum disorders |
| RS764229134 |
EYS
|
Health Risk |
Pathogenic |
Retinitis pigmentosa 25, Retinitis pigmentosa |
| RS764231441 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS764231534 |
ADGRV1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS764231632 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1G, Autosomal recessive limb-girdle muscular dystrophy type 2J |
| RS764231926 |
NSD1
|
Health Risk |
Conflicting classifications of pathogenicity |
Sotos syndrome, Sotos syndrome |
| RS764232082 |
PRPF31
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinitis pigmentosa, Retinal dystrophy |
| RS764232113 |
MSH2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS764232504 |
DSP
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic right ventricular dysplasia 8, Woolly hair-skin fragility syndrome |
| RS764232985 |
GCK
|
Health Risk |
Likely pathogenic |
Monogenic diabetes, Maturity-onset diabetes of the young type 2 |
| RS764234046 |
SPRED1
|
Health Risk |
Pathogenic |
Legius syndrome, Cardiovascular phenotype |
| RS764234724 |
KMT2B
|
Health Risk |
Likely pathogenic |
— |
| RS764235096 |
SYNE1
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive ataxia, Beauce type |
| RS764235653 |
COL6A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Bethlem myopathy 1A, Bethlem myopathy 1A |
| RS764236220 |
LAMA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital muscular dystrophy due to partial LAMA2 deficiency, LAMA2-related muscular dystrophy |
| RS764236480 |
USH2A
|
Health Risk |
Likely pathogenic |
Retinal dystrophy, Retinal dystrophy |
| RS764236940 |
AGL
|
Health Risk |
Likely pathogenic |
Glycogen storage disease type III, Glycogen storage disease type III |
| RS764238274 |
AHDC1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS764238442 |
KRT83
|
Health Risk |
Conflicting classifications of pathogenicity |
Monilethrix, Monilethrix |
| RS764238525 |
GARS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Charcot-Marie-Tooth disease type 2, See cases |
| RS764238988 |
AR
|
Health Risk |
Conflicting classifications of pathogenicity |
Androgen resistance syndrome, Male infertility |
| RS764238999 |
CHRNA4
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant nocturnal frontal lobe epilepsy, Autosomal dominant nocturnal frontal lobe epilepsy |
| RS764239040 |
SAMD9L
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS764239923 |
GLDN
|
Health Risk |
Likely pathogenic |
Lethal congenital contracture syndrome 11, Lethal congenital contracture syndrome 11 |
| RS764240226 |
MYO7A
|
Health Risk |
Pathogenic |
— |
| RS764240457 |
CEP290
|
Health Risk |
Conflicting classifications of pathogenicity |
Meckel-Gruber syndrome, Nephronophthisis |
| RS764241362 |
COL12A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Ullrich congenital muscular dystrophy 2, Bethlem myopathy 2 |
| RS764241934 |
RYR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS764242694 |
COL6A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Bethlem myopathy 1A, Bethlem myopathy 1A |
| RS764242699 |
CD46
|
Health Risk |
Conflicting classifications of pathogenicity |
Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, CD46-related disorder |
| RS764242924 |
DTNA
|
Health Risk |
Conflicting classifications of pathogenicity |
Left ventricular noncompaction 1, Left ventricular noncompaction 1 |
| RS764242946 |
COL4A4
|
Health Risk |
Likely pathogenic |
Autosomal recessive Alport syndrome, Autosomal recessive Alport syndrome |
| RS764243269 |
TTN
|
Health Risk |
Pathogenic/Likely pathogenic |
Primary dilated cardiomyopathy, Dilated cardiomyopathy 1G |
| RS764243782 |
FOXL2
|
Health Risk |
Pathogenic |
Premature ovarian failure 3, Blepharophimosis |
| RS764244307 |
PEX26
|
Health Risk |
Conflicting classifications of pathogenicity |
Peroxisome biogenesis disorder 7A (Zellweger), Peroxisome biogenesis disorder 7B |
| RS764244331 |
NOD2
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Regional enteritis |
| RS764244626 |
CDH23
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS764244639 |
STK11
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Peutz-Jeghers syndrome |
| RS764244718 |
CDKN2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial melanoma, Melanoma-pancreatic cancer syndrome |
| RS764245090 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive limb-girdle muscular dystrophy type 2J, Dilated cardiomyopathy 1G |
| RS764245230 |
NEK10
|
Health Risk |
Likely pathogenic |
Ciliary dyskinesia, primary |
| RS764245266 |
BBS1
|
Health Risk |
Pathogenic |
Bardet-Biedl syndrome 1, Bardet-Biedl syndrome |
| RS764246302 |
CC2D2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Meckel-Gruber syndrome, Joubert syndrome |
| RS764246939 |
MET
|
Health Risk |
Conflicting classifications of pathogenicity |
Renal cell carcinoma, Hereditary cancer-predisposing syndrome |
| RS764247288 |
SLC12A1
|
Health Risk |
Pathogenic/Likely pathogenic |
Bartter disease type 1, Bartter disease type 1 |
| RS764247545 |
BCKDHA
|
Health Risk |
Conflicting classifications of pathogenicity |
Maple syrup urine disease, Maple syrup urine disease type 1A |
| RS764247879 |
STIM1
|
Health Risk |
Conflicting classifications of pathogenicity |
Myopathy with tubular aggregates, Combined immunodeficiency due to STIM1 deficiency |
| RS764248656 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive limb-girdle muscular dystrophy type 2J, Dilated cardiomyopathy 1G |
| RS764248881 |
ADGRV1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS764248927 |
BRCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS764250397 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS764251007 |
DYSF
|
Health Risk |
Pathogenic |
Neuromuscular disease caused by qualitative or quantitative defects of dysferlin, Neuromuscular disease caused by qualitative or quantitative defects of dysferlin |
| RS764251434 |
CYP11B1
|
Health Risk |
Likely pathogenic |
Deficiency of steroid 11-beta-monooxygenase, Deficiency of steroid 11-beta-monooxygenase |
| RS764251922 |
KCNH2
|
Health Risk |
Pathogenic |
— |
| RS764251996 |
MYO15A
|
Health Risk |
Pathogenic/Likely pathogenic |
Autosomal recessive nonsyndromic hearing loss 3, Autosomal recessive nonsyndromic hearing loss 3 |
| RS764252130 |
PINK1
|
Health Risk |
Likely pathogenic |
Autosomal recessive early-onset Parkinson disease 6, Autosomal recessive early-onset Parkinson disease 6 |
| RS764252217 |
PMS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS764254189 |
AFG3L2
|
Health Risk |
Likely pathogenic |
Spastic ataxia 5, Spastic ataxia 5 |
| RS764254441 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS764255899 |
TPM3
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital myopathy with fiber type disproportion, Congenital myopathy 4B |
| RS764255983 |
APC
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 1 |
| RS764256655 |
CRB1
|
Health Risk |
Pathogenic/Likely pathogenic |
Macular dystrophy, Retinitis pigmentosa 12 |
| RS764256720 |
BRIP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Fanconi anemia complementation group J, Familial cancer of breast |
| RS764256845 |
TPP1
|
Health Risk |
Pathogenic/Likely pathogenic |
Neuronal ceroid lipofuscinosis, Neuronal ceroid lipofuscinosis 2 |
| RS764259203 |
ADAMTS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Ehlers-Danlos syndrome, dermatosparaxis type |
| RS764259746 |
SYNGAP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual disability, autosomal dominant 5 |
| RS764260054 |
RAB3GAP1
|
Health Risk |
Pathogenic |
Warburg micro syndrome 1, Warburg micro syndrome 1 |
| RS764260414 |
AGPAT2
|
Health Risk |
Pathogenic |
Congenital generalized lipodystrophy type 1, Congenital generalized lipodystrophy type 1 |
| RS764260671 |
SCN10A
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Brugada syndrome |
| RS764261431 |
ANO5
|
Health Risk |
Conflicting classifications of pathogenicity |
Gnathodiaphyseal dysplasia, Autosomal recessive limb-girdle muscular dystrophy type 2L |
| RS764262014 |
EIF2B1
|
Health Risk |
Pathogenic |
— |
| RS764262032 |
DNAH5
|
Health Risk |
Pathogenic |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS764262245 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia 7, Primary ciliary dyskinesia |
| RS764262446 |
RYR1
|
Health Risk |
Pathogenic/Likely pathogenic |
RYR1-related disorder, Central core myopathy |