SCN2B Chromosome 11
Sodium voltage-gated channel beta subunit 2
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What This Gene Does
The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]
Gene Info
Gene Group
"V-set domain containing|Sodium voltage-gated channel beta subunits"
Locus Type
gene with protein product
Location
11q23.3
Ensembl
ENSG00000149575
Associated Conditions (4)
Atrial fibrillation
familial
14
Cardiovascular phenotype
Key Variants
RS1064796044
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
RS115353159
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
RS144248214
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
RS17121818
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
RS17121819
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
RS200264107
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
RS367981116
Conflicting classifications of pathogenicity
Cardiovascular phenotype, Atrial fibrillation, familial
Health Risk
RS72544145
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
RS758238682
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
RS764221630
Conflicting classifications of pathogenicity
Cardiovascular phenotype, Atrial fibrillation, familial
Health Risk
RS765743471
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
RS774866184
Conflicting classifications of pathogenicity
Atrial fibrillation, familial, 14
Health Risk
All Variants (12)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1064796044 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |
| RS115353159 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |
| RS144248214 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |
| RS17121818 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |
| RS17121819 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |
| RS200264107 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |
| RS367981116 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Atrial fibrillation, familial |
| RS72544145 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |
| RS758238682 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |
| RS764221630 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Atrial fibrillation, familial |
| RS765743471 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |
| RS774866184 | Health Risk | Conflicting classifications of pathogenicity | Atrial fibrillation, familial, 14 |