| RS746493490 |
SLC16A2
|
Health Risk |
Likely pathogenic |
Allan-Herndon-Dudley syndrome, Allan-Herndon-Dudley syndrome |
| RS746493706 |
INF2
|
Health Risk |
Conflicting classifications of pathogenicity |
Focal segmental glomerulosclerosis 5, Charcot-Marie-Tooth disease dominant intermediate E |
| RS746496916 |
TREM2
|
Health Risk |
Conflicting classifications of pathogenicity |
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2, Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 |
| RS746497338 |
TCIRG1
|
Health Risk |
Pathogenic |
— |
| RS746499102 |
SLC25A12
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS746499337 |
ATM
|
Health Risk |
Pathogenic |
Ataxia-telangiectasia syndrome, Familial cancer of breast |
| RS746499570 |
C5
|
Health Risk |
Likely pathogenic |
— |
| RS746499646 |
EYS
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinal dystrophy, Retinitis pigmentosa 25 |
| RS746500019 |
DRAM2
|
Health Risk |
Likely pathogenic |
Cone-rod dystrophy 21, Cone-rod dystrophy 21 |
| RS746500238 |
FLNB
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS746500530 |
MCCC1
|
Health Risk |
Pathogenic/Likely pathogenic |
3-methylcrotonyl-CoA carboxylase 1 deficiency, Methylcrotonyl-CoA carboxylase deficiency |
| RS746501220 |
SCN3A
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS746501563 |
ADSL
|
Health Risk |
Pathogenic |
Adenylosuccinate lyase deficiency, Adenylosuccinate lyase deficiency |
| RS746501731 |
CDHR1
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinal dystrophy, Cone-rod dystrophy 15 |
| RS746502408 |
RTTN
|
Health Risk |
Pathogenic |
— |
| RS746503581 |
SNORD118
|
Health Risk |
Pathogenic |
Leukoencephalopathy with calcifications and cysts, Leukoencephalopathy with calcifications and cysts |
| RS746504075 |
TP53
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome |
| RS746505361 |
ARIH1
|
Health Risk |
association |
Aortic aneurysm, Aortic aneurysm |
| RS746506432 |
FBLN5
|
Health Risk |
Pathogenic |
Cutis laxa, autosomal recessive |
| RS746506506 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS746507078 |
GALC
|
Health Risk |
Pathogenic/Likely pathogenic |
Galactosylceramide beta-galactosidase deficiency, Galactosylceramide beta-galactosidase deficiency |
| RS746507528 |
FLCN
|
Health Risk |
Conflicting classifications of pathogenicity |
Birt-Hogg-Dube syndrome, Hereditary cancer-predisposing syndrome |
| RS746508651 |
GPR179
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS746509804 |
KCNJ1
|
Health Risk |
Pathogenic/Likely pathogenic |
Bartter disease type 2, Bartter disease type 2 |
| RS746511029 |
ZNF469
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Cardiovascular phenotype |
| RS746511283 |
ASNS
|
Health Risk |
Likely pathogenic |
— |
| RS74651202 |
SLC2A9
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypouricemia, renal |
| RS746513362 |
RDH12
|
Health Risk |
Conflicting classifications of pathogenicity |
Leber congenital amaurosis 13, Retinitis pigmentosa |
| RS746513550 |
MMADHC
|
Health Risk |
Likely pathogenic |
Methylmalonic aciduria and homocystinuria type cblD, Methylmalonic aciduria and homocystinuria type cblD |
| RS746513660 |
ASAH1
|
Health Risk |
Likely pathogenic |
Farber lipogranulomatosis, Farber lipogranulomatosis |
| RS746514008 |
DMD
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Duchenne muscular dystrophy |
| RS746514019 |
MAN2B1
|
Health Risk |
Conflicting classifications of pathogenicity |
Deficiency of alpha-mannosidase, Deficiency of alpha-mannosidase |
| RS746514288 |
FANCA
|
Health Risk |
Likely pathogenic |
Fanconi anemia, Gastric cancer |
| RS746514747 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS746515147 |
CASR
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial hypocalciuric hypercalcemia, Autosomal dominant hypocalcemia 1 |
| RS746516356 |
SUCLA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Mitochondrial DNA depletion syndrome, encephalomyopathic form with methylmalonic aciduria |
| RS746517026 |
DSP
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiomyopathy, Arrhythmogenic right ventricular dysplasia 8 |
| RS746517083 |
STIM1
|
Health Risk |
Conflicting classifications of pathogenicity |
Stormorken syndrome, Combined immunodeficiency due to STIM1 deficiency |
| RS746518509 |
FANCA
|
Health Risk |
Likely pathogenic |
Fanconi anemia complementation group A, Fanconi anemia |
| RS746519257 |
ECHS1
|
Health Risk |
Pathogenic/Likely pathogenic |
Mitochondrial short-chain Enoyl-Coa hydratase 1 deficiency, See cases |
| RS746519259 |
ALDH3A2
|
Health Risk |
Conflicting classifications of pathogenicity |
Sjögren-Larsson syndrome, Sjögren-Larsson syndrome |
| RS746520319 |
SCN8A
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Early-infantile DEE |
| RS746521110 |
EGFR
|
Health Risk |
Conflicting classifications of pathogenicity |
EGFR-related lung cancer, Hereditary cancer-predisposing syndrome |
| RS746521429 |
VPS13B
|
Health Risk |
Likely pathogenic |
Cohen syndrome, Cohen syndrome |
| RS746522150 |
CEBPA
|
Health Risk |
Conflicting classifications of pathogenicity |
Acute myeloid leukemia, Inborn genetic diseases |
| RS746523071 |
CLRN1
|
Health Risk |
Pathogenic/Likely pathogenic |
Usher syndrome type 3, Retinal dystrophy |
| RS746523125 |
TRIO
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS746523421 |
POMT1
|
Health Risk |
Pathogenic/Likely pathogenic |
Autosomal recessive limb-girdle muscular dystrophy type 2K, Muscular dystrophy-dystroglycanopathy (congenital with intellectual disability) |
| RS746523921 |
EDA
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypohidrotic X-linked ectodermal dysplasia, Inborn genetic diseases |
| RS746525428 |
TNXB
|
Health Risk |
Pathogenic |
— |
| RS746525639 |
SETX
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Spinocerebellar ataxia |
| RS746526239 |
MSH2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary nonpolyposis colorectal neoplasms |
| RS746527135 |
GRIN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant |
| RS746530389 |
PKP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic right ventricular dysplasia 9, Cardiovascular phenotype |
| RS746531116 |
FOXE3
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital primary aphakia, Anterior segment dysgenesis |
| RS746531354 |
KARS1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS746532062 |
SLC4A11
|
Health Risk |
Pathogenic/Likely pathogenic |
Congenital hereditary endothelial dystrophy of cornea, Congenital hereditary endothelial dystrophy of cornea |
| RS746532292 |
SPTAN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Developmental and epileptic encephalopathy, 5 |
| RS746532720 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS74653330 |
OCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Tyrosinase-positive oculocutaneous albinism, OCA2-related disorder |
| RS746533703 |
DSP
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic cardiomyopathy with wooly hair and keratoderma, Arrhythmogenic right ventricular dysplasia 8 |
| RS746533953 |
FKRP
|
Health Risk |
Pathogenic |
Walker-Warburg congenital muscular dystrophy, Walker-Warburg congenital muscular dystrophy |
| RS746534141 |
GLI3
|
Health Risk |
Conflicting classifications of pathogenicity |
Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome |
| RS746535031 |
ANKRD26
|
Health Risk |
Conflicting classifications of pathogenicity |
Thrombocytopenia 2, ANKRD26-related disorder |
| RS746536339 |
BRWD3
|
Health Risk |
Likely pathogenic |
Intellectual disability, X-linked 93 |
| RS746536721 |
MLH1
|
Health Risk |
Pathogenic/Likely pathogenic |
Hereditary nonpolyposis colorectal neoplasms, Colorectal cancer |
| RS746536941 |
CACNA1G
|
Health Risk |
Conflicting classifications of pathogenicity |
CACNA1G-related disorder, Inborn genetic diseases |
| RS746537400 |
CACNA1H
|
Health Risk |
Conflicting classifications of pathogenicity |
Idiopathic generalized epilepsy, Hyperaldosteronism |
| RS746537493 |
DVL1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS746538436 |
GFM2
|
Health Risk |
Pathogenic |
Mitochondrial disease, Combined oxidative phosphorylation deficiency 39 |
| RS746538672 |
RYR1
|
Health Risk |
Conflicting classifications of pathogenicity |
RYR1-related disorder, RYR1-related myopathy |
| RS746541034 |
CASR
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant hypocalcemia 1, Familial hypocalciuric hypercalcemia |
| RS746541266 |
ABCA4
|
Health Risk |
Pathogenic |
Severe early-childhood-onset retinal dystrophy, Age related macular degeneration 2 |
| RS746541677 |
CEACAM16
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS746542615 |
HOXB13
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS746542712 |
FLNC
|
Health Risk |
Conflicting classifications of pathogenicity |
Distal myopathy with posterior leg and anterior hand involvement, Hypertrophic cardiomyopathy 26 |
| RS746543001 |
DYNC1H1
|
Health Risk |
Conflicting classifications of pathogenicity |
See cases, Charcot-Marie-Tooth disease axonal type 2O |
| RS746544641 |
FANCI
|
Health Risk |
Pathogenic |
Fanconi anemia, Fanconi anemia |
| RS746546834 |
ALMS1
|
Health Risk |
Likely pathogenic |
Alstrom syndrome, Alstrom syndrome |
| RS746547282 |
ADCY5
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS746548465 |
TTN
|
Health Risk |
Likely pathogenic |
Dilated cardiomyopathy 1G, Autosomal recessive limb-girdle muscular dystrophy type 2J |
| RS746549330 |
CNGB3
|
Health Risk |
Conflicting classifications of pathogenicity |
Severe early-childhood-onset retinal dystrophy, Achromatopsia |
| RS746550765 |
AGL
|
Health Risk |
Conflicting classifications of pathogenicity |
Glycogen storage disease type III, Inborn genetic diseases |
| RS746550786 |
SCN11A
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary sensory and autonomic neuropathy type 7, Familial episodic pain syndrome with predominantly lower limb involvement |
| RS746551074 |
GBA2
|
Health Risk |
Pathogenic |
Spastic paraplegia, Spastic paraplegia |
| RS746551311 |
USH2A
|
Health Risk |
Pathogenic |
Retinitis pigmentosa, Usher syndrome type 2A |
| RS746551717 |
RASA1
|
Health Risk |
Conflicting classifications of pathogenicity |
Capillary malformation-arteriovenous malformation syndrome, Cardiovascular phenotype |
| RS746552269 |
MYO15A
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive nonsyndromic hearing loss 3, Inborn genetic diseases |
| RS746552340 |
NEB
|
Health Risk |
Conflicting classifications of pathogenicity |
Nemaline myopathy 2, Inborn genetic diseases |
| RS746552548 |
PDE6B
|
Health Risk |
Pathogenic |
Retinal dystrophy, Retinal dystrophy |
| RS746552692 |
DYNC1H1
|
Health Risk |
Conflicting classifications of pathogenicity |
Charcot-Marie-Tooth disease axonal type 2O, Inborn genetic diseases |
| RS746555296 |
SUFU
|
Health Risk |
Conflicting classifications of pathogenicity |
Gorlin syndrome, Medulloblastoma |
| RS746555297 |
CYP7B1
|
Health Risk |
Conflicting classifications of pathogenicity |
Spastic paraplegia, Spastic paraplegia |
| RS746556715 |
MMUT
|
Health Risk |
Pathogenic |
Methylmalonic acidemia, Methylmalonic aciduria due to complete methylmalonyl-CoA mutase deficiency |
| RS746557446 |
CHRNA4
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant nocturnal frontal lobe epilepsy, Autosomal dominant nocturnal frontal lobe epilepsy |
| RS746558975 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive limb-girdle muscular dystrophy type 2J, Tibial muscular dystrophy |
| RS746559651 |
DRAM2
|
Health Risk |
Pathogenic |
Retinal dystrophy, Cone-rod dystrophy 21 |
| RS746560886 |
TCOF1
|
Health Risk |
Conflicting classifications of pathogenicity |
Treacher Collins syndrome 1, Treacher Collins syndrome 1 |
| RS746562608 |
MYH3
|
Health Risk |
Conflicting classifications of pathogenicity |
Distal arthrogryposis type 2B1, Freeman-Sheldon syndrome |
| RS746562872 |
LSS
|
Health Risk |
Pathogenic |
Alopecia-intellectual disability syndrome 4, Alopecia-intellectual disability syndrome 4 |