| RS748005956 |
MEN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Multiple endocrine neoplasia, type 1 |
| RS748006253 |
AQP2
|
Health Risk |
Pathogenic |
— |
| RS748006255 |
FANCD2
|
Health Risk |
Likely pathogenic |
Fanconi anemia complementation group D2, Fanconi anemia complementation group D2 |
| RS748006260 |
NEDD4L
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual disability, Intellectual disability |
| RS748006603 |
TYK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Immunodeficiency 35, Immunodeficiency 35 |
| RS748007203 |
CRPPA
|
Health Risk |
Pathogenic |
Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A |
| RS748007443 |
USH2A
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS748007618 |
TBK1
|
Health Risk |
Pathogenic/Likely pathogenic |
Frontotemporal dementia and/or amyotrophic lateral sclerosis 4, Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 |
| RS748007790 |
DMD
|
Health Risk |
Conflicting classifications of pathogenicity |
Duchenne muscular dystrophy, Becker muscular dystrophy |
| RS748007891 |
MYO18B
|
Health Risk |
Pathogenic/Likely pathogenic |
MYO18B-related disorder, MYO18B-related disorder |
| RS748008197 |
SLC10A1
|
Health Risk |
Likely pathogenic |
SLC10A1-related disorder, SLC10A1-related disorder |
| RS748009402 |
IFT81
|
Health Risk |
Pathogenic |
— |
| RS748009590 |
PC
|
Health Risk |
Likely pathogenic |
Pyruvate carboxylase deficiency, Pyruvate carboxylase deficiency |
| RS748010172 |
APC
|
Health Risk |
Pathogenic |
Familial adenomatous polyposis 1, Hereditary cancer-predisposing syndrome |
| RS748010262 |
CLPB
|
Health Risk |
Pathogenic |
3-methylglutaconic aciduria, type VIIB |
| RS748010810 |
SOX11
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748011297 |
COL4A4
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Autosomal recessive Alport syndrome |
| RS748011724 |
MCPH1
|
Health Risk |
Pathogenic/Likely pathogenic |
Microcephaly 1, primary |
| RS748012447 |
SKIC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Trichohepatoenteric syndrome 2, Trichohepatoenteric syndrome 2 |
| RS748012743 |
NDUFA12
|
Health Risk |
Pathogenic |
— |
| RS748013805 |
AHNAK2
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS748014296 |
CFAP418
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinitis pigmentosa 64, Retinitis pigmentosa 64 |
| RS748014865 |
BBS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Bardet-Biedl syndrome, BBS2-related disorder |
| RS748016039 |
MSH3
|
Health Risk |
Pathogenic/Likely pathogenic |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 4 |
| RS748016341 |
TUBGCP6
|
Health Risk |
Pathogenic |
— |
| RS748016594 |
KIF23
|
Health Risk |
Likely pathogenic |
Microcephaly, Microcephaly |
| RS748017801 |
ALK
|
Health Risk |
Conflicting classifications of pathogenicity |
Neuroblastoma, susceptibility to |
| RS748017885 |
LITAF
|
Health Risk |
Conflicting classifications of pathogenicity |
Charcot-Marie-Tooth disease, Charcot-Marie-Tooth disease type 1C |
| RS748018297 |
KANSL1
|
Health Risk |
Pathogenic |
Koolen-de Vries syndrome, Koolen-de Vries syndrome |
| RS748018742 |
PKHD1
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive polycystic kidney disease, Autosomal recessive polycystic kidney disease |
| RS748019294 |
PGM1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748019757 |
COL7A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748019972 |
TAP2
|
Health Risk |
Pathogenic |
MHC class I deficiency, MHC class I deficiency |
| RS748020048 |
MYH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Aortic aneurysm, familial thoracic 4 |
| RS748021245 |
CACNA1S
|
Health Risk |
Conflicting classifications of pathogenicity |
Malignant hyperthermia, susceptibility to |
| RS748022092 |
ALG6
|
Health Risk |
Likely pathogenic |
ALG6-congenital disorder of glycosylation 1C, ALG6-congenital disorder of glycosylation 1C |
| RS748022323 |
RTEL1
|
Health Risk |
Conflicting classifications of pathogenicity |
Dyskeratosis congenita, autosomal recessive 5 |
| RS748022439 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive limb-girdle muscular dystrophy type 2J, Dilated cardiomyopathy 1G |
| RS748022451 |
GTPBP3
|
Health Risk |
Likely pathogenic |
— |
| RS748022488 |
BICD2
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures, BICD2-related disorder |
| RS748022925 |
BAP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, BAP1-related tumor predisposition syndrome |
| RS748026507 |
IVD
|
Health Risk |
Likely pathogenic |
Isovaleryl-CoA dehydrogenase deficiency, Isovaleryl-CoA dehydrogenase deficiency |
| RS748026747 |
COL4A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Alport syndrome, Alport syndrome |
| RS748026887 |
COL4A3
|
Health Risk |
Pathogenic |
Autosomal recessive Alport syndrome, Alport syndrome |
| RS748026968 |
NDUFA11
|
Health Risk |
Likely pathogenic |
Mitochondrial complex I deficiency, nuclear type 14 |
| RS748027595 |
NF1
|
Health Risk |
Conflicting classifications of pathogenicity |
Neurofibromatosis, type 1 |
| RS748028684 |
MCCC2
|
Health Risk |
Conflicting classifications of pathogenicity |
3-methylcrotonyl-CoA carboxylase 2 deficiency, 3-methylcrotonyl-CoA carboxylase 2 deficiency |
| RS748029308 |
DCAF17
|
Health Risk |
Likely pathogenic |
Woodhouse-Sakati syndrome, Papillary renal cell carcinoma type 1 |
| RS748031071 |
ALPL
|
Health Risk |
Likely pathogenic |
Infantile hypophosphatasia, Hypophosphatasia |
| RS748031178 |
PTEN
|
Health Risk |
Likely pathogenic |
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS748032310 |
CAPN3
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive limb-girdle muscular dystrophy type 2A, Autosomal recessive limb-girdle muscular dystrophy type 2A |
| RS748032659 |
PEX6
|
Health Risk |
Conflicting classifications of pathogenicity |
Peroxisome biogenesis disorder, PEX6-related disorder |
| RS748032810 |
KCNV2
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748034053 |
ACTN2
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary familial hypertrophic cardiomyopathy, Dilated cardiomyopathy 1AA |
| RS748034744 |
CEP290
|
Health Risk |
Conflicting classifications of pathogenicity |
Joubert syndrome 5, Retinal dystrophy |
| RS748035948 |
COL6A2
|
Health Risk |
Pathogenic |
Ullrich congenital muscular dystrophy 1B, Ullrich congenital muscular dystrophy 1B |
| RS748036380 |
PCNT
|
Health Risk |
Conflicting classifications of pathogenicity |
Microcephalic osteodysplastic primordial dwarfism type II, PCNT-related disorder |
| RS748036782 |
CHD7
|
Health Risk |
Conflicting classifications of pathogenicity |
CHARGE syndrome, Hypogonadotropic hypogonadism 5 with or without anosmia |
| RS748036956 |
GAA
|
Health Risk |
Conflicting classifications of pathogenicity |
Glycogen storage disease, type II |
| RS748037660 |
SLC6A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Epilepsy with myoclonic atonic seizures |
| RS748037957 |
PIGG
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual disability, autosomal recessive 53 |
| RS748038054 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
TTN-related disorder, Cardiomyopathy |
| RS748042028 |
NAGLU
|
Health Risk |
Pathogenic |
Mucopolysaccharidosis, MPS-III-B |
| RS748042110 |
ITPA
|
Health Risk |
Pathogenic |
Inosine triphosphatase deficiency, ITPA-related disorder |
| RS748042738 |
DNAI1
|
Health Risk |
Likely pathogenic |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS748043014 |
TBX18
|
Health Risk |
Likely pathogenic |
Congenital anomaly of kidney and urinary tract, Congenital anomaly of kidney and urinary tract |
| RS748043225 |
RAD51C
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O |
| RS748044865 |
ABCB4
|
Health Risk |
Conflicting classifications of pathogenicity |
ABCB4-related disorder, ABCB4-related disorder |
| RS748045691 |
WT1
|
Health Risk |
Conflicting classifications of pathogenicity |
Wilms tumor 1, 11p partial monosomy syndrome |
| RS748046147 |
APC
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 1 |
| RS748046278 |
NAGS
|
Health Risk |
Conflicting classifications of pathogenicity |
Hyperammonemia, type III |
| RS748046539 |
TRPM1
|
Health Risk |
Likely pathogenic |
Congenital stationary night blindness, Congenital stationary night blindness |
| RS748046758 |
REST
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS748047271 |
GAA
|
Health Risk |
Likely pathogenic |
Glycogen storage disease, type II |
| RS748047359 |
ABCG5
|
Health Risk |
Conflicting classifications of pathogenicity |
Sitosterolemia 2, Sitosterolemia |
| RS748047522 |
COL6A2
|
Health Risk |
Conflicting classifications of pathogenicity |
Bethlem myopathy 1A, Bethlem myopathy 1A |
| RS748048179 |
NEB
|
Health Risk |
Conflicting classifications of pathogenicity |
Nemaline myopathy 2, Nemaline myopathy 2 |
| RS748048642 |
RYR1
|
Health Risk |
Pathogenic |
RYR1-related disorder, RYR1-related disorder |
| RS748048928 |
SPG11
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary spastic paraplegia 11, Inborn genetic diseases |
| RS748049105 |
PNPLA6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary spastic paraplegia 39, Hereditary spastic paraplegia 39 |
| RS748049143 |
LRP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Donnai-Barrow syndrome, Donnai-Barrow syndrome |
| RS748049681 |
MOCS2
|
Health Risk |
Pathogenic |
Sulfite oxidase deficiency due to molybdenum cofactor deficiency type B, Combined molybdoflavoprotein enzyme deficiency |
| RS748051713 |
FBN2
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital contractural arachnodactyly, Familial thoracic aortic aneurysm and aortic dissection |
| RS748052337 |
MBD5
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual disability, autosomal dominant 1 |
| RS748053172 |
COL6A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Bethlem myopathy 1A, Bethlem myopathy 1A |
| RS748054907 |
GRIN2B
|
Health Risk |
Conflicting classifications of pathogenicity |
Developmental and epileptic encephalopathy, 27 |
| RS748055124 |
TRPM1
|
Health Risk |
Pathogenic |
— |
| RS748055961 |
CBL
|
Health Risk |
Conflicting classifications of pathogenicity |
RASopathy, See cases |
| RS748057401 |
HSD17B4
|
Health Risk |
Likely pathogenic |
Bifunctional peroxisomal enzyme deficiency, Perrault syndrome |
| RS748057725 |
SPG11
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary spastic paraplegia 11, Hereditary spastic paraplegia 11 |
| RS748058327 |
HMCN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Age related macular degeneration 1, Age related macular degeneration 1 |
| RS748060377 |
JAG1
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Alagille syndrome due to a JAG1 point mutation |
| RS748061846 |
TBK1
|
Health Risk |
Conflicting classifications of pathogenicity |
Frontotemporal dementia and/or amyotrophic lateral sclerosis 4, Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 |
| RS748063409 |
APC
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 1 |
| RS748064828 |
FAT4
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS748064845 |
NF1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Neurofibromatosis |
| RS748064846 |
MED12
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial thoracic aortic aneurysm and aortic dissection, FG syndrome |
| RS748065332 |
MYSM1
|
Health Risk |
Pathogenic |
— |
| RS748067492 |
ATR
|
Health Risk |
Conflicting classifications of pathogenicity |
Seckel syndrome 1, Seckel syndrome 1 |
| RS748068839 |
COL27A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |