KIF23 Chromosome 15
Kinesin family member 23
Upload your DNA to see your personal genotypes for variants in KIF23.
What This Gene Does
The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Info
Gene Group
Kinesins
Locus Type
gene with protein product
Location
15q23
Ensembl
ENSG00000137807
Associated Conditions (6)
KIF23-related disorder
Malignant tumor of urinary bladder
Ovarian serous cystadenocarcinoma
Congenital dyserythropoietic anemia
type III
Microcephaly
Key Variants
RS137922672
Conflicting classifications of pathogenicity
KIF23-related disorder, KIF23-related disorder
Health Risk
RS143219911
Conflicting classifications of pathogenicity
Health Risk
RS148511930
Conflicting classifications of pathogenicity
Health Risk
RS150307169
Conflicting classifications of pathogenicity
KIF23-related disorder, KIF23-related disorder
Health Risk
RS199679829
Conflicting classifications of pathogenicity
Malignant tumor of urinary bladder, Malignant tumor of urinary bladder
Health Risk
RS372828681
Conflicting classifications of pathogenicity
Health Risk
RS375380237
Conflicting classifications of pathogenicity
Health Risk
RS543990042
Conflicting classifications of pathogenicity
Ovarian serous cystadenocarcinoma, Ovarian serous cystadenocarcinoma
Health Risk
RS560614661
Conflicting classifications of pathogenicity
Health Risk
RS748182171
Conflicting classifications of pathogenicity
Health Risk
RS2140422904
Likely pathogenic
Congenital dyserythropoietic anemia, type III, Congenital dyserythropoietic anemia
Health Risk
RS748016594
Likely pathogenic
Microcephaly, Microcephaly
Health Risk
All Variants (13)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS137922672 | Health Risk | Conflicting classifications of pathogenicity | KIF23-related disorder, KIF23-related disorder |
| RS143219911 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS148511930 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS150307169 | Health Risk | Conflicting classifications of pathogenicity | KIF23-related disorder, KIF23-related disorder |
| RS199679829 | Health Risk | Conflicting classifications of pathogenicity | Malignant tumor of urinary bladder, Malignant tumor of urinary bladder |
| RS372828681 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS375380237 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS543990042 | Health Risk | Conflicting classifications of pathogenicity | Ovarian serous cystadenocarcinoma, Ovarian serous cystadenocarcinoma |
| RS560614661 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS748182171 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS2140422904 | Health Risk | Likely pathogenic | Congenital dyserythropoietic anemia, type III, Congenital dyserythropoietic anemia |
| RS748016594 | Health Risk | Likely pathogenic | Microcephaly, Microcephaly |
| RS2140424959 | Health Risk | Pathogenic | Congenital dyserythropoietic anemia, type III, Congenital dyserythropoietic anemia |