PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2142300433 | Health Risk | Pathogenic | Fanconi anemia complementation group N, Fanconi anemia complementation group N |
| RS2142325956 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142326522 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142326602 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142327117 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142327301 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142328321 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142328421 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142334914 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142334934 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142337034 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142343437 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142344237 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary breast ovarian cancer syndrome, Familial cancer of breast |
| RS2142353165 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142353580 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142354911 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142355316 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142355636 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142356386 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142367705 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142368459 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142368508 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142373865 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142374295 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142374794 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142377240 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142377985 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142381049 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142382015 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142382651 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142382796 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142383088 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142384044 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142384476 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142384677 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2142385006 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142386226 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142386640 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2142386665 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142388816 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142389921 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142389968 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142390387 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142390444 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142390682 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2142410052 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142411591 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142412137 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142412586 | Health Risk | Pathogenic | Familial cancer of breast, PALB2-related cancer predisposition, Familial cancer of breast |
| RS2142412914 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |