PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1597088146 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597088245 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1597089246 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1597089434 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597089469 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597089741 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597089845 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597089904 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597090059 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597090146 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1597090324 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1597090596 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597090656 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1597090662 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597090894 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597091230 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597091247 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597095394 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1597095683 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS1597096326 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597096338 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597097072 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597097182 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS1597097263 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1597097408 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597097438 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast, Familial cancer of breast |
| RS1597097656 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597098094 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1597098138 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597098679 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597098971 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597098996 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597099149 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial prostate cancer |
| RS1597099331 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS1597099523 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597101532 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597101822 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS180177084 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer |
| RS180177085 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS180177090 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer |
| RS180177091 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer |
| RS180177092 | Health Risk | Pathogenic | Familial cancer of breast, Fanconi anemia complementation group N, Hereditary cancer-predisposing syndrome |
| RS180177094 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS180177097 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS180177098 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS180177099 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Lynch syndrome 1 |
| RS180177102 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS180177103 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS180177110 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS180177111 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |