PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS180177113 | Health Risk | Pathogenic | Fanconi anemia complementation group N, Fanconi anemia complementation group N |
| RS180177116 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS180177124 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS180177126 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS180177131 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS180177134 | Health Risk | Pathogenic | Fanconi anemia complementation group N, Fanconi anemia complementation group N |
| RS180177135 | Health Risk | Pathogenic | Fanconi anemia complementation group N, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS180177138 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1966506715 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1966508003 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966508734 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966509881 | Health Risk | Pathogenic | Familial cancer of breast, Gastric cancer, Familial cancer of breast |
| RS1966510490 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1966511830 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966637056 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966771199 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966771907 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966773290 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966801432 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966842281 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966842388 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966842668 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966842803 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966853670 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Gastric cancer |
| RS1966853795 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966855544 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966855759 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966856088 | Health Risk | Pathogenic | — |
| RS1966856585 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966856749 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966856854 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966856962 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966857445 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966858159 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1966858562 | Health Risk | Pathogenic | Familial cancer of breast, Gastric cancer, Familial cancer of breast |
| RS1966861838 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966861886 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1966861906 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966861952 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966862226 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966862297 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966863076 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966864164 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966864847 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS1966865214 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS1966865368 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966865768 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1966865838 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1966866081 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966866862 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |