PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2142415370 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142416277 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142416694 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2142416902 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142417496 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142418150 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2142418386 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142418871 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142419403 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142421147 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142422279 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142423775 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2142423901 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142424706 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142424902 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142425504 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142426385 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142426807 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142426861 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142426926 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142428256 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142429230 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142429833 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142431560 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142432029 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142432244 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142432863 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142433522 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142433539 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142434483 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142434725 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142435242 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142435343 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142437289 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142437926 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142438133 | Health Risk | Pathogenic | Gastric cancer, Gastric cancer |
| RS2142438340 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142439618 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142440747 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142443124 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142443334 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142443741 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142443848 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142444567 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142445986 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142447291 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142455866 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142456344 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142457035 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142460813 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |