PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2506331963 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506334991 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506335230 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506335630 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506336030 | Health Risk | Pathogenic | — |
| RS2506336717 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506337849 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506348737 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506348819 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS2506349749 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506350050 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506351360 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506351687 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast, Familial cancer of breast |
| RS2506369573 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506369925 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506369952 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506370297 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506372023 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506372150 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506372227 | Health Risk | Pathogenic | — |
| RS2506372450 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506374385 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506395456 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506395620 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506395721 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary breast ovarian cancer syndrome, Familial cancer of breast |
| RS2506396546 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506396717 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506397207 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506402179 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506402781 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506403585 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506403717 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast, Familial cancer of breast |
| RS2506404518 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506404649 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506404802 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506404974 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506405176 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506405916 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506406330 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506407120 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506407851 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506408745 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506409634 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506411505 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506411822 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast-ovarian cancer |
| RS2506412078 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506412613 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506412992 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506413313 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506414559 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |