PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2506490234 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506490399 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506490833 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506492135 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506492295 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506492767 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506493372 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506494090 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506494447 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506494522 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506495630 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506495781 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506495873 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506496202 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506496389 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506496675 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506497326 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506497427 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506497719 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506497835 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506498360 | Health Risk | Pathogenic | Familial cancer of breast, Inherited breast cancer and ovarian cancer, Familial cancer of breast |
| RS2506498384 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506498622 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506498901 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506499894 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506499986 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506500182 | Health Risk | Pathogenic | Hereditary breast ovarian cancer syndrome, Hereditary breast ovarian cancer syndrome |
| RS2506500559 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506500607 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506500879 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506500998 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506503909 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506504746 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506505884 | Health Risk | Pathogenic | Gastric cancer, Familial cancer of breast, Gastric cancer |
| RS2506505979 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506506429 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506506605 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506506863 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506506942 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506507300 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506507642 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506508888 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506508979 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506509176 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506511810 | Health Risk | Pathogenic | Hereditary breast ovarian cancer syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS2506512121 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506512269 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506513116 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506513330 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506513633 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |