PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS587776420 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587776424 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast-ovarian cancer |
| RS587776425 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587776426 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS587776427 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS587778584 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587780210 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS587780211 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587780817 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS587781560 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587781697 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast and/or ovarian cancer |
| RS587781840 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast cancer |
| RS587781890 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587782005 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS587782081 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS587782217 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast-ovarian cancer |
| RS587782232 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS587782337 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS587782446 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587782531 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS587782570 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS587782680 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS587782892 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS730881866 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS730881867 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS730881868 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS730881869 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS730881870 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS730881871 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS730881872 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS730881903 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS730881905 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS745533713 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS746604683 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS747148023 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS749078410 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS749602688 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related disorder |
| RS749731838 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS750782778 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS752592662 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS753676934 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS755471995 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS756018344 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS756519825 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS757055720 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS757369748 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Pancreatic cancer, susceptibility to |
| RS757860709 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS761533286 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast, Familial cancer of breast |
| RS763745734 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS769163259 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |