| RS763113534 |
RYR1
|
Health Risk |
Conflicting classifications of pathogenicity |
RYR1-related disorder, Malignant hyperthermia |
| RS763113675 |
EIF2AK3
|
Health Risk |
Pathogenic/Likely pathogenic |
Wolcott-Rallison dysplasia, Wolcott-Rallison dysplasia |
| RS763114190 |
SCN2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Developmental and epileptic encephalopathy, 11 |
| RS763114755 |
CACNA1H
|
Health Risk |
Conflicting classifications of pathogenicity |
Idiopathic generalized epilepsy, Hyperaldosteronism |
| RS763115397 |
ROR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Brachydactyly type B1, Autosomal recessive Robinow syndrome |
| RS763115687 |
PIGM
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency, Hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency |
| RS763115697 |
PAH
|
Health Risk |
Likely pathogenic |
Phenylketonuria, Phenylketonuria |
| RS763117746 |
UNC13D
|
Health Risk |
Pathogenic |
Familial hemophagocytic lymphohistiocytosis 3, Familial hemophagocytic lymphohistiocytosis 3 |
| RS763118688 |
ADAMTSL4
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS763119040 |
DYNC1H1
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant cerebellar ataxia, Charcot-Marie-Tooth disease axonal type 2O |
| RS763119311 |
TCIRG1
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive osteopetrosis 1, TCIRG1-related disorder |
| RS763119319 |
POMT2
|
Health Risk |
Conflicting classifications of pathogenicity |
Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2 |
| RS763119366 |
PTCH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Gorlin syndrome, Hereditary cancer-predisposing syndrome |
| RS763122264 |
CRB1
|
Health Risk |
Conflicting classifications of pathogenicity |
Leber congenital amaurosis 8, Retinitis pigmentosa 12 |
| RS763122825 |
NTRK1
|
Health Risk |
Pathogenic/Likely pathogenic |
Hereditary insensitivity to pain with anhidrosis, Hereditary insensitivity to pain with anhidrosis |
| RS763122999 |
TSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Tuberous sclerosis 2, Hereditary cancer-predisposing syndrome |
| RS763123951 |
TSC2
|
Health Risk |
Pathogenic |
Tuberous sclerosis 2, Tuberous sclerosis 2 |
| RS763126378 |
SPG7
|
Health Risk |
Pathogenic |
Hereditary spastic paraplegia 7, Hereditary spastic paraplegia 7 |
| RS763126633 |
FILIP1
|
Health Risk |
Pathogenic |
Neuromuscular disorder, congenital |
| RS763126846 |
AHI1
|
Health Risk |
Conflicting classifications of pathogenicity |
Joubert syndrome, Inborn genetic diseases |
| RS763127023 |
USH2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive retinitis pigmentosa, Autosomal recessive retinitis pigmentosa |
| RS763127279 |
STIL
|
Health Risk |
Conflicting classifications of pathogenicity |
Microcephaly 7, primary |
| RS763129394 |
C9
|
Health Risk |
Likely pathogenic |
— |
| RS763130672 |
ANK2
|
Health Risk |
Likely pathogenic |
Long QT syndrome, Long QT syndrome |
| RS763130915 |
SLC19A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Biotin-responsive basal ganglia disease, Biotin-responsive basal ganglia disease |
| RS763131793 |
CD46
|
Health Risk |
Pathogenic |
— |
| RS763132585 |
TCTN3
|
Health Risk |
Pathogenic/Likely pathogenic |
Orofacial-digital syndrome IV, Joubert syndrome 18 |
| RS763132615 |
SHH
|
Health Risk |
Pathogenic |
Holoprosencephaly 3, Holoprosencephaly 3 |
| RS763132789 |
EFL1
|
Health Risk |
Likely pathogenic |
Shwachman-Diamond syndrome 2, Shwachman syndrome |
| RS763133096 |
SYNE2
|
Health Risk |
Conflicting classifications of pathogenicity |
Emery-Dreifuss muscular dystrophy 5, autosomal dominant |
| RS763133592 |
GRIN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant |
| RS763136492 |
ANK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Long QT syndrome, Cardiovascular phenotype |
| RS763136509 |
CDH3
|
Health Risk |
Conflicting classifications of pathogenicity |
EEM syndrome, EEM syndrome |
| RS763136667 |
MED12
|
Health Risk |
Conflicting classifications of pathogenicity |
FG syndrome, FG syndrome |
| RS763140298 |
IFT140
|
Health Risk |
Conflicting classifications of pathogenicity |
Saldino-Mainzer syndrome, Retinitis pigmentosa 80 |
| RS763140976 |
NOTCH1
|
Health Risk |
Conflicting classifications of pathogenicity |
Adams-Oliver syndrome 5, Familial thoracic aortic aneurysm and aortic dissection |
| RS763141634 |
ZBTB18
|
Health Risk |
Likely pathogenic |
Intellectual disability, autosomal dominant 22 |
| RS763144679 |
MPL
|
Health Risk |
Pathogenic |
Congenital amegakaryocytic thrombocytopenia, Essential thrombocythemia |
| RS763144937 |
SECISBP2
|
Health Risk |
Pathogenic |
Thyroid hormone metabolism, abnormal 1 |
| RS763145238 |
RAD50
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Nijmegen breakage syndrome-like disorder |
| RS763146296 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS763146463 |
POMGNT1
|
Health Risk |
Pathogenic |
— |
| RS763146574 |
RYR1
|
Health Risk |
Likely pathogenic |
— |
| RS763146679 |
HOGA1
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary hyperoxaluria type 3, Primary hyperoxaluria type 3 |
| RS763147599 |
LDLR
|
Health Risk |
Likely pathogenic |
Hypercholesterolemia, familial |
| RS763149283 |
ABCA1
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Cardiovascular phenotype |
| RS763151358 |
FANCE
|
Health Risk |
Conflicting classifications of pathogenicity |
Carcinoma of colon, Fanconi anemia complementation group E |
| RS763151392 |
CNGB3
|
Health Risk |
Pathogenic/Likely pathogenic |
Achromatopsia 3, Achromatopsia 3 |
| RS763153590 |
WDR87
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS763154396 |
JAG1
|
Health Risk |
Conflicting classifications of pathogenicity |
Alagille syndrome due to a JAG1 point mutation, Cardiovascular phenotype |
| RS763154774 |
POLR3B
|
Health Risk |
Pathogenic/Likely pathogenic |
Hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism, Hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism |
| RS763155183 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS763155375 |
UCP3
|
Health Risk |
Conflicting classifications of pathogenicity |
UCP3-related disorder, Obesity |
| RS763156837 |
LYST
|
Health Risk |
Conflicting classifications of pathogenicity |
Chédiak-Higashi syndrome, Autoinflammatory syndrome |
| RS763158250 |
TTC21B
|
Health Risk |
Conflicting classifications of pathogenicity |
Jeune thoracic dystrophy, Nephronophthisis |
| RS763158627 |
SHANK3
|
Health Risk |
Pathogenic |
Phelan-McDermid syndrome, Phelan-McDermid syndrome |
| RS763159512 |
NEDD4L
|
Health Risk |
Conflicting classifications of pathogenicity |
Periventricular nodular heterotopia 7, Periventricular nodular heterotopia 7 |
| RS763159520 |
ALPL
|
Health Risk |
Likely pathogenic |
Inborn genetic diseases, Infantile hypophosphatasia |
| RS763160213 |
MYBPC3
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypertrophic cardiomyopathy, Cardiomyopathy |
| RS763160290 |
MEN1
|
Health Risk |
Conflicting classifications of pathogenicity |
Multiple endocrine neoplasia, type 1 |
| RS763161866 |
CACNA1H
|
Health Risk |
Conflicting classifications of pathogenicity |
Idiopathic generalized epilepsy, Hyperaldosteronism |
| RS763161932 |
GNRHR
|
Health Risk |
Pathogenic/Likely pathogenic |
— |
| RS763162233 |
NPHS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Finnish congenital nephrotic syndrome, Finnish congenital nephrotic syndrome |
| RS763162379 |
BRIP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group J |
| RS763162492 |
ACADS
|
Health Risk |
Conflicting classifications of pathogenicity |
Deficiency of butyryl-CoA dehydrogenase, ACADS-related disorder |
| RS763162669 |
RFXAP
|
Health Risk |
Conflicting classifications of pathogenicity |
MHC class II deficiency, MHC class II deficiency |
| RS763162762 |
COL6A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Bethlem myopathy 1A, COL6A3-related disorder |
| RS763162787 |
NHS
|
Health Risk |
Conflicting classifications of pathogenicity |
See cases, Nance-Horan syndrome |
| RS763162812 |
TPP1
|
Health Risk |
Pathogenic |
Neuronal ceroid lipofuscinosis 2, Autosomal recessive spinocerebellar ataxia 7 |
| RS763163879 |
NEB
|
Health Risk |
Likely pathogenic |
Nemaline myopathy 2, Arthrogryposis multiplex congenita 6 |
| RS763164530 |
JAG1
|
Health Risk |
Conflicting classifications of pathogenicity |
Alagille syndrome due to a JAG1 point mutation, Cardiovascular phenotype |
| RS763165014 |
DPYD
|
Health Risk |
Conflicting classifications of pathogenicity |
Dihydropyrimidine dehydrogenase deficiency, Dihydropyrimidine dehydrogenase deficiency |
| RS763165541 |
GTPBP3
|
Health Risk |
Conflicting classifications of pathogenicity |
Combined oxidative phosphorylation defect type 23, Inborn genetic diseases |
| RS763165545 |
GLI2
|
Health Risk |
Pathogenic |
Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome, Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome |
| RS763166039 |
PLCG2
|
Health Risk |
Conflicting classifications of pathogenicity |
Familial cold autoinflammatory syndrome 3, Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation |
| RS763166498 |
SCN4A
|
Health Risk |
Conflicting classifications of pathogenicity |
Hyperkalemic periodic paralysis, Hypokalemic periodic paralysis |
| RS763166660 |
ABCA3
|
Health Risk |
Pathogenic |
Hereditary pulmonary alveolar proteinosis, Interstitial lung disease due to ABCA3 deficiency |
| RS763168158 |
FKBP14
|
Health Risk |
Conflicting classifications of pathogenicity |
Ehlers-Danlos syndrome, kyphoscoliotic type |
| RS76316834 |
DBH
|
Health Risk |
Conflicting classifications of pathogenicity |
Orthostatic hypotension 1, Inborn genetic diseases |
| RS763168997 |
GPR143
|
Health Risk |
Pathogenic |
— |
| RS763169900 |
ATL1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Hereditary spastic paraplegia 3A |
| RS763170220 |
EXPH5
|
Health Risk |
Conflicting classifications of pathogenicity |
Epidermolysis bullosa simplex 4, localized or generalized intermediate |
| RS763171566 |
SOX2
|
Health Risk |
Conflicting classifications of pathogenicity |
Anophthalmia/microphthalmia-esophageal atresia syndrome, Anophthalmia/microphthalmia-esophageal atresia syndrome |
| RS763174042 |
RPS20
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS763174055 |
CHEK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS763175161 |
HNRNPDL
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant limb-girdle muscular dystrophy type 1G, Autosomal dominant limb-girdle muscular dystrophy type 1G |
| RS763176856 |
DCHS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS763178268 |
MYH7
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiomyopathy, Hypertrophic cardiomyopathy |
| RS763178849 |
MAT1A
|
Health Risk |
Pathogenic |
Hepatic methionine adenosyltransferase deficiency, Hepatic methionine adenosyltransferase deficiency |
| RS763182554 |
ABCA12
|
Health Risk |
Pathogenic |
— |
| RS763183520 |
FH
|
Health Risk |
Conflicting classifications of pathogenicity |
Fumarase deficiency, Hereditary cancer-predisposing syndrome |
| RS763183959 |
KMT2B
|
Health Risk |
Pathogenic |
Dystonia 28, childhood-onset |
| RS763183991 |
TSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Tuberous sclerosis 2, Hereditary cancer-predisposing syndrome |
| RS763184168 |
MSH2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS763184444 |
APC
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 1 |
| RS763184652 |
INPP5E
|
Health Risk |
Conflicting classifications of pathogenicity |
Joubert syndrome 1, Joubert syndrome |
| RS763184657 |
GALNS
|
Health Risk |
Pathogenic/Likely pathogenic |
Mucopolysaccharidosis, MPS-IV-A |
| RS763185312 |
DNAJB6
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant limb-girdle muscular dystrophy type 1D (DNAJB6), Inborn genetic diseases |
| RS763185527 |
PRX
|
Health Risk |
Conflicting classifications of pathogenicity |
Charcot-Marie-Tooth disease type 4F, Charcot-Marie-Tooth disease type 4 |
| RS763186690 |
MTHFR
|
Health Risk |
Pathogenic |
Spasticity, Bilateral tonic-clonic seizure |