| RS758051329 |
BRCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS758051786 |
TBX6
|
Health Risk |
Pathogenic |
Spondylocostal dysostosis 5, Spondylocostal dysostosis 5 |
| RS758051959 |
BRCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Wilms tumor 1, Hereditary cancer-predisposing syndrome |
| RS758052437 |
PDE6B
|
Health Risk |
Likely pathogenic |
Retinitis pigmentosa 40, Retinitis pigmentosa 40 |
| RS75805245 |
NBAS
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS758052634 |
IFT140
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinitis pigmentosa 80, Retinal dystrophy |
| RS758054052 |
ANK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Long QT syndrome, Primary dilated cardiomyopathy |
| RS758054171 |
MSH2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS758054913 |
SLCO2A1
|
Health Risk |
Pathogenic |
Hypertrophic osteoarthropathy, primary |
| RS758055364 |
LIFR
|
Health Risk |
Pathogenic/Likely pathogenic |
Cervical cancer, Stüve-Wiedemann syndrome 1 |
| RS758055753 |
HSD17B4
|
Health Risk |
Pathogenic/Likely pathogenic |
Bifunctional peroxisomal enzyme deficiency, Perrault syndrome 1 |
| RS758056561 |
ATM
|
Health Risk |
Conflicting classifications of pathogenicity |
Ataxia-telangiectasia syndrome, Hereditary cancer-predisposing syndrome |
| RS758056583 |
OPA1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS758057228 |
CEP250
|
Health Risk |
Pathogenic |
— |
| RS758057774 |
AAAS
|
Health Risk |
Pathogenic |
Glucocorticoid deficiency with achalasia, Glucocorticoid deficiency with achalasia |
| RS758057846 |
DSCAML1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS758057930 |
GTPBP3
|
Health Risk |
Likely pathogenic |
See cases, See cases |
| RS758058076 |
WNK4
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Pseudohypoaldosteronism type 2B |
| RS758058521 |
ASL
|
Health Risk |
Likely pathogenic |
— |
| RS758058910 |
CAPN3
|
Health Risk |
Pathogenic |
Autosomal recessive limb-girdle muscular dystrophy type 2A, Autosomal recessive limb-girdle muscular dystrophy |
| RS758061248 |
CNGB3
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS758061831 |
KIT
|
Health Risk |
Conflicting classifications of pathogenicity |
Gastrointestinal stromal tumor, Hereditary cancer-predisposing syndrome |
| RS758062617 |
FANCI
|
Health Risk |
Pathogenic/Likely pathogenic |
Fanconi anemia, Fanconi anemia complementation group I |
| RS758064613 |
COL9A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Skeletal dysplasia |
| RS758066597 |
TAF1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS758067709 |
APOB
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Hypercholesterolemia |
| RS758069019 |
ABCB11
|
Health Risk |
Pathogenic |
Progressive familial intrahepatic cholestasis type 2, Benign recurrent intrahepatic cholestasis type 2 |
| RS758069398 |
KCNT1
|
Health Risk |
Conflicting classifications of pathogenicity |
Developmental and epileptic encephalopathy, 14 |
| RS758070332 |
LAMA5
|
Health Risk |
Likely pathogenic |
Developmental disorder, Developmental disorder |
| RS758073166 |
MYO18B
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS758073208 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiomyopathy, Dilated cardiomyopathy 1G |
| RS758073557 |
COL6A2
|
Health Risk |
Conflicting classifications of pathogenicity |
Bethlem myopathy 1A, Bethlem myopathy 1A |
| RS758073965 |
ADA
|
Health Risk |
Pathogenic/Likely pathogenic |
Severe combined immunodeficiency, autosomal recessive |
| RS758074713 |
KCNQ2
|
Health Risk |
Conflicting classifications of pathogenicity |
Early-infantile DEE, Inborn genetic diseases |
| RS758075470 |
SMCHD1
|
Health Risk |
Conflicting classifications of pathogenicity |
Facioscapulohumeral muscular dystrophy 2, Facioscapulohumeral muscular dystrophy 2 |
| RS758076661 |
COL4A1
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome, Brain small vessel disease 1 with or without ocular anomalies |
| RS758078849 |
SGCG
|
Health Risk |
Pathogenic |
Autosomal recessive limb-girdle muscular dystrophy type 2C, Autosomal recessive limb-girdle muscular dystrophy type 2C |
| RS758079491 |
P3H1
|
Health Risk |
Pathogenic |
Osteogenesis imperfecta type 8, Osteogenesis imperfecta type 8 |
| RS758080422 |
FLNC
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Myofibrillar myopathy 5 |
| RS758080566 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS758081262 |
ATM
|
Health Risk |
Pathogenic |
Ataxia-telangiectasia syndrome, Familial cancer of breast |
| RS758081534 |
KMT2E
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS758083405 |
USP9X
|
Health Risk |
Pathogenic |
Inborn genetic diseases, USP9X-related disorder |
| RS758083563 |
ATM
|
Health Risk |
Conflicting classifications of pathogenicity |
Ataxia-telangiectasia syndrome, Hereditary cancer-predisposing syndrome |
| RS758085966 |
FLNB
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS758086020 |
GNE
|
Health Risk |
Conflicting classifications of pathogenicity |
Sialuria, GNE myopathy |
| RS758086677 |
FASTKD2
|
Health Risk |
Conflicting classifications of pathogenicity |
FASTKD2-related disorder, Combined oxidative phosphorylation deficiency 44 |
| RS758087535 |
SPRED1
|
Health Risk |
Conflicting classifications of pathogenicity |
Legius syndrome, Cardiovascular phenotype |
| RS758087836 |
SERPINC1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary antithrombin deficiency, Hereditary antithrombin deficiency |
| RS758087862 |
ALDH5A1
|
Health Risk |
Pathogenic |
Succinate-semialdehyde dehydrogenase deficiency, Succinate-semialdehyde dehydrogenase deficiency |
| RS758088548 |
TARS2
|
Health Risk |
Likely pathogenic |
Combined oxidative phosphorylation defect type 21, Combined oxidative phosphorylation defect type 21 |
| RS75808917 |
TDP1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS758090662 |
ABCA4
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS758091260 |
SMARCA4
|
Health Risk |
Conflicting classifications of pathogenicity |
Rhabdoid tumor predisposition syndrome 2, Hereditary cancer-predisposing syndrome |
| RS758091261 |
RRM2B
|
Health Risk |
Conflicting classifications of pathogenicity |
Mitochondrial DNA depletion syndrome 8a, Rod-cone dystrophy |
| RS758091898 |
PAX2
|
Health Risk |
Conflicting classifications of pathogenicity |
Focal segmental glomerulosclerosis 7, Renal coloboma syndrome |
| RS758092571 |
KCNJ2
|
Health Risk |
Conflicting classifications of pathogenicity |
Andersen Tawil syndrome, Short QT syndrome type 3 |
| RS758092761 |
CEBPA
|
Health Risk |
Conflicting classifications of pathogenicity |
Acute myeloid leukemia, Inborn genetic diseases |
| RS758093235 |
HBA1
|
Health Risk |
Likely pathogenic |
Erythrocytosis, familial |
| RS758093517 |
TYRP1
|
Health Risk |
Pathogenic |
— |
| RS758094020 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1G, Autosomal recessive limb-girdle muscular dystrophy type 2J |
| RS758094541 |
FASTKD2
|
Health Risk |
Pathogenic |
Combined oxidative phosphorylation deficiency 44, Combined oxidative phosphorylation deficiency 44 |
| RS758095361 |
USH2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinal dystrophy, Usher syndrome |
| RS758096259 |
COL4A4
|
Health Risk |
Conflicting classifications of pathogenicity |
Microscopic hematuria, Microscopic hematuria |
| RS758096402 |
SH3BP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Fibrous dysplasia of jaw, Inborn genetic diseases |
| RS758096681 |
TOPORS
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinitis pigmentosa, Inborn genetic diseases |
| RS758097199 |
PKP2
|
Health Risk |
Pathogenic |
Arrhythmogenic right ventricular dysplasia 9, Cardiovascular phenotype |
| RS758098717 |
ALMS1
|
Health Risk |
Pathogenic |
Alstrom syndrome, Intellectual disability |
| RS758100348 |
TRPM4
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Progressive familial heart block type IB |
| RS758100382 |
DHPS
|
Health Risk |
Pathogenic/Likely pathogenic |
Neurodevelopmental disorder with seizures and speech and walking impairment, DHPS-related disorder |
| RS758101035 |
SALL1
|
Health Risk |
Conflicting classifications of pathogenicity |
Townes syndrome, Townes syndrome |
| RS758101066 |
SCN5A
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive familial heart block, type 1A |
| RS758101067 |
SYNGAP1
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual disability, autosomal dominant 5 |
| RS758101910 |
FAT4
|
Health Risk |
Conflicting classifications of pathogenicity |
Van Maldergem syndrome 2, Hennekam lymphangiectasia-lymphedema syndrome 2 |
| RS758102115 |
DCT
|
Health Risk |
Pathogenic |
Oculocutaneous albinism type 8, Oculocutaneous albinism type 8 |
| RS758102180 |
CHEK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS758104018 |
ADGRV1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS758105619 |
NEB
|
Health Risk |
Pathogenic/Likely pathogenic |
Nemaline myopathy, Arthrogryposis multiplex congenita 6 |
| RS758105856 |
MCM7
|
Health Risk |
Pathogenic |
Meier-Gorlin syndrome, 9 conditions |
| RS758106272 |
FRAS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Fraser syndrome 1, Fraser syndrome 1 |
| RS758106362 |
APC
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 1 |
| RS758106590 |
NF1
|
Health Risk |
Conflicting classifications of pathogenicity |
Neurofibromatosis, type 1 |
| RS758107024 |
DYSF
|
Health Risk |
Pathogenic |
Autosomal recessive limb-girdle muscular dystrophy type 2B, Abnormality of the musculature |
| RS758107642 |
LMBRD1
|
Health Risk |
Likely pathogenic |
Methylmalonic aciduria and homocystinuria type cblF, Methylmalonic aciduria and homocystinuria type cblF |
| RS758108369 |
HTRA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Parkinson disease 13, autosomal dominant |
| RS758108455 |
EIF2AK3
|
Health Risk |
Pathogenic |
— |
| RS758109676 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1G, Early-onset myopathy with fatal cardiomyopathy |
| RS758109813 |
EYS
|
Health Risk |
Pathogenic |
Retinitis pigmentosa 25, Retinal dystrophy |
| RS758109864 |
DNAI2
|
Health Risk |
Likely pathogenic |
Primary ciliary dyskinesia, Respiratory ciliopathies including non-CF bronchiectasis |
| RS758110629 |
PRF1
|
Health Risk |
Pathogenic/Likely pathogenic |
Familial hemophagocytic lymphohistiocytosis 2, Familial hemophagocytic lymphohistiocytosis |
| RS758110675 |
TERT
|
Health Risk |
Conflicting classifications of pathogenicity |
7 conditions, Dyskeratosis congenita |
| RS758111285 |
ACADM
|
Health Risk |
Pathogenic/Likely pathogenic |
Medium-chain acyl-coenzyme A dehydrogenase deficiency, Medium-chain acyl-coenzyme A dehydrogenase deficiency |
| RS758111714 |
DOCK7
|
Health Risk |
Pathogenic/Likely pathogenic |
Developmental and epileptic encephalopathy, 23 |
| RS758111969 |
KIF1A
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary spastic paraplegia 30, Neuropathy |
| RS758112271 |
RYR1
|
Health Risk |
Conflicting classifications of pathogenicity |
RYR1-related disorder, Malignant hyperthermia |
| RS758112770 |
POLG
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive sclerosing poliodystrophy, Neurodevelopmental delay |
| RS758112779 |
DNAH5
|
Health Risk |
Pathogenic/Likely pathogenic |
Primary ciliary dyskinesia, Primary ciliary dyskinesia 3 |
| RS758113478 |
SCN4A
|
Health Risk |
Conflicting classifications of pathogenicity |
Hyperkalemic periodic paralysis, 6 conditions |
| RS758115945 |
TYR
|
Health Risk |
Pathogenic |
Oculocutaneous albinism type 1A, TYR-related disorder |
| RS758116389 |
FANCC
|
Health Risk |
Pathogenic/Likely pathogenic |
Fanconi anemia complementation group C, Fanconi anemia |