| RS755206242 |
AXIN2
|
Health Risk |
Conflicting classifications of pathogenicity |
Oligodontia-cancer predisposition syndrome, Hereditary cancer-predisposing syndrome |
| RS755206422 |
SMO
|
Health Risk |
Conflicting classifications of pathogenicity |
Curry-Jones syndrome, Curry-Jones syndrome |
| RS755208325 |
ADAMTS17
|
Health Risk |
Likely pathogenic |
— |
| RS755208949 |
PYROXD1
|
Health Risk |
Pathogenic |
Myofibrillar myopathy 8, Myofibrillar myopathy 8 |
| RS755209169 |
RAI1
|
Health Risk |
Conflicting classifications of pathogenicity |
RAI1-related disorder, RAI1-related disorder |
| RS755209182 |
BRCA1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS755210880 |
STK11
|
Health Risk |
Conflicting classifications of pathogenicity |
Peutz-Jeghers syndrome, Hereditary cancer-predisposing syndrome |
| RS755211647 |
CLCN1
|
Health Risk |
Pathogenic |
Congenital myotonia, autosomal dominant form |
| RS755211944 |
GOSR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Progressive myoclonic epilepsy, Progressive myoclonic epilepsy type 6 |
| RS755212646 |
FOCAD
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS755212969 |
CDK13
|
Health Risk |
Conflicting classifications of pathogenicity |
Congenital heart defects, dysmorphic facial features |
| RS755213908 |
NBAS
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS755214552 |
ETFDH
|
Health Risk |
Pathogenic/Likely pathogenic |
Multiple acyl-CoA dehydrogenase deficiency, Multiple acyl-CoA dehydrogenase deficiency |
| RS755214586 |
MBD5
|
Health Risk |
Conflicting classifications of pathogenicity |
Intellectual disability, autosomal dominant 1 |
| RS755215116 |
LRP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Donnai-Barrow syndrome, Donnai-Barrow syndrome |
| RS755215178 |
PKP2
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic right ventricular dysplasia 9, Cardiomyopathy |
| RS755215367 |
MSH6
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary nonpolyposis colorectal neoplasms, Hereditary cancer-predisposing syndrome |
| RS755216120 |
TNPO3
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant limb-girdle muscular dystrophy type 1F, TNPO3-related disorder |
| RS755216810 |
MCM4
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency, Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency |
| RS755217589 |
OBSL1
|
Health Risk |
Conflicting classifications of pathogenicity |
3M syndrome 2, Inborn genetic diseases |
| RS755218546 |
covers 10 genes, none of which curated to show dosage sensitivity
|
Health Risk |
Conflicting classifications of pathogenicity |
Crigler-Najjar syndrome type 1, Crigler-Najjar syndrome |
| RS755218835 |
USH2A
|
Health Risk |
Pathogenic |
Retinitis pigmentosa 39, Retinal dystrophy |
| RS755219421 |
NHS
|
Health Risk |
Conflicting classifications of pathogenicity |
Nance-Horan syndrome, Nance-Horan syndrome |
| RS755219790 |
CYBC1
|
Health Risk |
Likely pathogenic |
— |
| RS755219802 |
ANK1
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary spherocytosis type 1, Spherocytosis |
| RS755221106 |
CACNA1G
|
Health Risk |
Pathogenic |
Spinocerebellar ataxia type 42, Spinocerebellar ataxia 42 |
| RS755221482 |
BRCA1
|
Health Risk |
Conflicting classifications of pathogenicity |
Malignant tumor of breast, Hereditary cancer-predisposing syndrome |
| RS755221742 |
CACNA1S
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypokalemic periodic paralysis, Malignant hyperthermia |
| RS755222145 |
MUTYH
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS755222515 |
AHCY
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Rhabdomyolysis |
| RS755222875 |
NDUFS6
|
Health Risk |
Conflicting classifications of pathogenicity |
Mitochondrial complex I deficiency, nuclear type 1 |
| RS755222977 |
NCF2
|
Health Risk |
Conflicting classifications of pathogenicity |
Granulomatous disease, chronic |
| RS755223158 |
GUCY2D
|
Health Risk |
Conflicting classifications of pathogenicity |
Cone-rod dystrophy 6, Leber congenital amaurosis 1 |
| RS755223611 |
RRAS
|
Health Risk |
Conflicting classifications of pathogenicity |
Noonan syndrome, Noonan syndrome |
| RS755224034 |
ITGB4
|
Health Risk |
Conflicting classifications of pathogenicity |
Junctional epidermolysis bullosa with pyloric atresia, Epidermolysis bullosa |
| RS755225286 |
CDKN1B
|
Health Risk |
Conflicting classifications of pathogenicity |
Multiple endocrine neoplasia type 4, Hereditary cancer-predisposing syndrome |
| RS755226061 |
PKD2
|
Health Risk |
Pathogenic |
Polycystic kidney disease 2, Autosomal dominant polycystic kidney disease |
| RS755226463 |
PIEZO1
|
Health Risk |
Conflicting classifications of pathogenicity |
Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema, Lymphatic malformation 6 |
| RS755226547 |
AR
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Androgen resistance syndrome |
| RS755227053 |
BRCA2
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS755227074 |
ATP2A1
|
Health Risk |
Pathogenic/Likely pathogenic |
Brody myopathy, Brody myopathy |
| RS755227076 |
GLI3
|
Health Risk |
Conflicting classifications of pathogenicity |
Pallister-Hall syndrome, Greig cephalopolysyndactyly syndrome |
| RS755227174 |
VPS13B
|
Health Risk |
Conflicting classifications of pathogenicity |
Cohen syndrome, Inborn genetic diseases |
| RS755227541 |
TECTA
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive nonsyndromic hearing loss 21, Autosomal dominant nonsyndromic hearing loss 12 |
| RS755229056 |
IARS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome, Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome |
| RS755229386 |
TSC2
|
Health Risk |
Conflicting classifications of pathogenicity |
Tuberous sclerosis 2, Hereditary cancer-predisposing syndrome |
| RS755229531 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS755230915 |
DGKE
|
Health Risk |
Likely pathogenic |
Immunoglobulin-mediated membranoproliferative glomerulonephritis, Immunoglobulin-mediated membranoproliferative glomerulonephritis |
| RS755231246 |
ALK
|
Health Risk |
Conflicting classifications of pathogenicity |
Neuroblastoma, susceptibility to |
| RS755231595 |
ABCA12
|
Health Risk |
Pathogenic |
— |
| RS755232267 |
BLM
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Bloom syndrome |
| RS755233004 |
COL4A4
|
Health Risk |
Likely pathogenic |
Benign familial hematuria, Benign familial hematuria |
| RS755233845 |
SOS2
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Noonan syndrome 9 |
| RS755233964 |
ZEB2
|
Health Risk |
Conflicting classifications of pathogenicity |
Mowat-Wilson syndrome, Inborn genetic diseases |
| RS755234198 |
COPA
|
Health Risk |
Conflicting classifications of pathogenicity |
Autoimmune interstitial lung disease-arthritis syndrome, Autoimmune interstitial lung disease-arthritis syndrome |
| RS755234697 |
MET
|
Health Risk |
Conflicting classifications of pathogenicity |
Papillary renal cell carcinoma type 1, Hereditary cancer-predisposing syndrome |
| RS755235380 |
SDHC
|
Health Risk |
Pathogenic |
Pheochromocytoma/paraganglioma syndrome 3, Hereditary cancer-predisposing syndrome |
| RS755235399 |
DICER1
|
Health Risk |
Conflicting classifications of pathogenicity |
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS755235783 |
COL4A3
|
Health Risk |
Pathogenic |
— |
| RS755236236 |
COLQ
|
Health Risk |
Pathogenic/Likely pathogenic |
Congenital myasthenic syndrome 5, Congenital myasthenic syndrome 5 |
| RS755237333 |
PMM2
|
Health Risk |
Pathogenic |
PMM2-congenital disorder of glycosylation, PMM2-congenital disorder of glycosylation |
| RS755237394 |
SLC34A3
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal recessive hypophosphatemic bone disease, Autosomal recessive hypophosphatemic bone disease |
| RS755238050 |
CLN5
|
Health Risk |
Likely pathogenic |
Neuronal ceroid lipofuscinosis 5, Neuronal ceroid lipofuscinosis 5 |
| RS755238456 |
CERKL
|
Health Risk |
Pathogenic |
Autosomal recessive retinitis pigmentosa, Retinitis pigmentosa 26 |
| RS755239192 |
NEB
|
Health Risk |
Likely pathogenic |
Nemaline myopathy 2, Arthrogryposis multiplex congenita 6 |
| RS755240438 |
NPHP4
|
Health Risk |
Conflicting classifications of pathogenicity |
Nephronophthisis, Nephronophthisis |
| RS755240882 |
ANK2
|
Health Risk |
Conflicting classifications of pathogenicity |
Long QT syndrome, Cardiac arrhythmia |
| RS755243916 |
PPP2R5D
|
Health Risk |
Conflicting classifications of pathogenicity |
Acute myeloid leukemia, Acute myeloid leukemia |
| RS755243947 |
DSG2
|
Health Risk |
Conflicting classifications of pathogenicity |
Arrhythmogenic right ventricular dysplasia 10, Cardiovascular phenotype |
| RS755244502 |
ZNF469
|
Health Risk |
Conflicting classifications of pathogenicity |
Cardiovascular phenotype, Cardiovascular phenotype |
| RS755244582 |
ALPK3
|
Health Risk |
Pathogenic |
— |
| RS755244997 |
COL17A1
|
Health Risk |
Pathogenic |
— |
| RS755245061 |
HSD3B7
|
Health Risk |
Likely pathogenic |
— |
| RS755245286 |
STING1
|
Health Risk |
Conflicting classifications of pathogenicity |
STING-associated vasculopathy with onset in infancy, Inborn genetic diseases |
| RS755246809 |
AHI1
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinitis pigmentosa, Joubert syndrome 3 |
| RS755246924 |
TSEN2
|
Health Risk |
Likely pathogenic |
Pontocerebellar hypoplasia type 2B, Pontoneocerebellar hypoplasia |
| RS7552471 |
PCSK9
|
Health Risk |
Conflicting classifications of pathogenicity |
Hypercholesterolemia, familial |
| RS755247580 |
ACADS
|
Health Risk |
Likely pathogenic |
Deficiency of butyryl-CoA dehydrogenase, Deficiency of butyryl-CoA dehydrogenase |
| RS755248868 |
CLN8
|
Health Risk |
Conflicting classifications of pathogenicity |
Neuronal ceroid lipofuscinosis, Neuronal ceroid lipofuscinosis |
| RS755250590 |
IMPG2
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinitis pigmentosa, Retinitis pigmentosa |
| RS755252506 |
SLC20A2
|
Health Risk |
Pathogenic/Likely pathogenic |
SLC20A2-related disorder, Idiopathic basal ganglia calcification 1 |
| RS755253225 |
OBSCN
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS755253527 |
GAA
|
Health Risk |
Pathogenic |
Glycogen storage disease, type II |
| RS755254043 |
POMT2
|
Health Risk |
Conflicting classifications of pathogenicity |
Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A2 |
| RS755254230 |
NPHS1
|
Health Risk |
Conflicting classifications of pathogenicity |
Finnish congenital nephrotic syndrome, Finnish congenital nephrotic syndrome |
| RS755256285 |
DNAH11
|
Health Risk |
Conflicting classifications of pathogenicity |
Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS755256552 |
NFIX
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS755256694 |
SCN4A
|
Health Risk |
Conflicting classifications of pathogenicity |
Hyperkalemic periodic paralysis, 7 conditions |
| RS755256833 |
ABCA1
|
Health Risk |
Conflicting classifications of pathogenicity |
— |
| RS755257605 |
MPL
|
Health Risk |
Pathogenic/Likely pathogenic |
Congenital amegakaryocytic thrombocytopenia, Essential thrombocythemia |
| RS755257734 |
NAGS
|
Health Risk |
Pathogenic/Likely pathogenic |
Hyperammonemia, type III |
| RS75525811 |
DBT
|
Health Risk |
Conflicting classifications of pathogenicity |
Maple syrup urine disease, DBT-related disorder |
| RS755258233 |
CC2D2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Meckel-Gruber syndrome, Joubert syndrome |
| RS755259997 |
ABCC8
|
Health Risk |
Pathogenic/Likely pathogenic |
Hyperinsulinemic hypoglycemia, familial |
| RS755260088 |
NF1
|
Health Risk |
Conflicting classifications of pathogenicity |
Neurofibromatosis, type 1 |
| RS755260464 |
PADI6
|
Health Risk |
Likely pathogenic |
Preimplantation embryonic lethality 2, Preimplantation embryonic lethality 2 |
| RS755261062 |
TTN
|
Health Risk |
Likely pathogenic |
Primary dilated cardiomyopathy, Dilated cardiomyopathy 1G |
| RS755261571 |
RNF168
|
Health Risk |
Conflicting classifications of pathogenicity |
Inborn genetic diseases, Inborn genetic diseases |
| RS755262343 |
TTN
|
Health Risk |
Conflicting classifications of pathogenicity |
Dilated cardiomyopathy 1G, Autosomal recessive limb-girdle muscular dystrophy type 2J |
| RS755263300 |
HNF1B
|
Health Risk |
Conflicting classifications of pathogenicity |
Renal cysts and diabetes syndrome, Maturity-onset diabetes of the young |