RS439401 APOE

Drug Response Chr 19:44911193 snv non coding transcript exon variant

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What This Variant Does

"This appears to be the snp on the Illumina Human 550 which is closest to rs4420638 [GWAS:Triglyceri..."

Associated Conditions

Warfarin response

GWAS Studies (20)

Trait	Risk Allele	OR / Beta	P-value	Study
Monounsaturated fatty acids to total fatty acids percentage	T	—	2E-49	PubMed
Monounsaturated fatty acids to total fatty acids percentage	T	—	1E-48	PubMed
Polyunsaturated fatty acids to monounsaturated fatty acids ratio	T	—	8E-40	PubMed
Polyunsaturated fatty acids to monounsaturated fatty acids ratio	T	—	1E-39	PubMed
Height	T	β: 0.008	9E-36	PubMed
Triglycerides	T	OR: 5.5	1E-30	PubMed
Triglyceride levels	T	β: 0.029	5E-21	PubMed
1-oleoyl-3-linoleoyl-glycerol (18:1/18:2) levels	T	β: 0.096	1E-19	PubMed
Docosahexaenoic acid to total fatty acids percentage	T	—	6E-18	PubMed
Docosahexaenoic acid to total fatty acids percentage	T	—	8E-16	PubMed
Cholesteryl ester levels in HDL	T	β: 0.031	2E-15	PubMed
Alzheimer's disease	—	OR: 1.49	6E-14	PubMed
Triglyceride levels	—	—	1E-13	PubMed
HDL cholesterol levels	T	β: 0.028	3E-13	PubMed
Serum metabolite levels (CMS)	—	β: 0.047	6E-13	PubMed
Sphingomyelin_42:2_[M+H]1+ levels	T	OR: 0.1	2E-12	PubMed
Sphingomyelin_38:1_[M+H]1+ levels	T	β: 0.08	4E-11	PubMed
Triacylglyceride levels	C	β: 0.08	6E-11	PubMed
Sphingomyelin_42:2_[M+OAc]1- levels	T	β: 0.059	7E-11	PubMed
Aspartate aminotransferase levels	C	OR: 6.41	1E-10	PubMed

Population Frequencies

gnomAD ALL

28.2%

1kG AFR

12.2%

1kG ALL

40.5%

1kG AMR

48.4%

1kG EAS

55.6%

1kG EUR

38.1%

1kG SAS

42.1%

Other Variants in APOE