PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2506473795 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506474098 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506474382 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506474686 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506474995 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506476329 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506476872 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506477042 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506477052 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506477382 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506477430 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506477730 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506477824 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506478364 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506478562 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506478906 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506478950 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506479063 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506479181 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506479564 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506480353 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506480505 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506480937 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506481423 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506482111 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506482646 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506482665 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506482713 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506484093 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506484387 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506484574 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506484710 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506484896 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506485264 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506485498 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506485904 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506485985 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506486000 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506486066 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506486737 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506486770 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506487128 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506487272 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506487423 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506487913 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506488161 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506488587 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506488695 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506489045 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506489655 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |