PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2506514549 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506515350 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506515843 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506516970 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506517377 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506518476 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506519015 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506519342 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506533604 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506533950 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506534070 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506535967 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506536286 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506536640 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506539351 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506539704 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506539880 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506539952 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506540052 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506540669 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506572115 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506572755 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506572966 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS373287455 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS375699023 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Chordoma |
| RS45476495 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS45532440 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS45602040 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS515726060 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS515726065 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast, Familial cancer of breast |
| RS515726071 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS515726073 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS515726081 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related disorder |
| RS515726083 | Health Risk | Pathogenic | Familial cancer of breast, Breast-ovarian cancer, familial |
| RS515726103 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS515726104 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS515726122 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS515726123 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer |
| RS515726127 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS540962715 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS587776407 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS587776408 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587776409 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587776410 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS587776411 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587776412 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS587776413 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587776414 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587776416 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS587776418 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |