PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2506414771 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506415158 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506415396 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506415516 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506417320 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506417496 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506418304 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506418535 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506418702 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506418982 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506419032 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506419228 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506421462 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506421760 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506422670 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506423101 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506423965 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506424378 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506425029 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506426318 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506426669 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506428095 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506428661 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506429279 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506430807 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506432628 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506433317 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506434258 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506434602 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506434971 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506435147 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506435297 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506435689 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506435881 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506438451 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506438495 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506438793 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506439448 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506439815 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506469411 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506469600 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506469678 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506469754 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506469948 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506470426 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506470483 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506470530 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506470735 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506471654 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506472466 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |