PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2142461122 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142461160 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142481060 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142481327 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2488713769 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506195060 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506195102 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506196450 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2506196528 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506196853 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506197198 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506197229 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506197277 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506197342 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506197384 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506213403 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506213740 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506213838 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506213944 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506214204 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506214645 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506215030 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506215545 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506215585 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506215747 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506216070 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506216606 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506216974 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506217335 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506217535 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506218552 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506219037 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506219220 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506264526 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506264968 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506265040 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506265249 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506265842 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506266271 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506266710 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506317139 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506318177 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506318342 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506319191 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506319397 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506319680 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial |
| RS2506320174 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506320726 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506320907 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506331940 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |