PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1966952995 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1966955447 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966959467 | Health Risk | Pathogenic | Breast-ovarian cancer, familial, susceptibility to |
| RS1966967463 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1966971699 | Health Risk | Pathogenic | — |
| RS1966974831 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1966979701 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1966981959 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1966983494 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966986126 | Health Risk | Pathogenic | Breast and/or ovarian cancer, Breast and/or ovarian cancer |
| RS1966988658 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966989564 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1966999709 | Health Risk | Pathogenic | — |
| RS1967001584 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1967002076 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967002667 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1967007854 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, PALB2-related disorder, Hereditary breast ovarian cancer syndrome |
| RS1967011347 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1967016153 | Health Risk | Pathogenic | Gastric cancer, Gastric cancer |
| RS1967021173 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967023129 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967023691 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967026821 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967028249 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967030083 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967038226 | Health Risk | Pathogenic | — |
| RS1967048357 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967055062 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967056795 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967057527 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967100637 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967104136 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967113249 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1967113484 | Health Risk | Pathogenic | Gastric cancer, Gastric cancer |
| RS1967232172 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2142251164 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142251992 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142252096 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142252136 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142252484 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142252950 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142253220 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS2142254584 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142271504 | Health Risk | Pathogenic | Hereditary breast ovarian cancer syndrome, Hereditary breast ovarian cancer syndrome |
| RS2142272095 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142273197 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142273676 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142274423 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142298541 | Health Risk | Pathogenic | Pancreatic cancer, susceptibility to, 3 |
| RS2142300225 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast, Hereditary cancer-predisposing syndrome |