PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1555461788 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461790 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461796 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS1555461825 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461846 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461868 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555462031 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS1567204928 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567206733 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567206799 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567206804 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567206813 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567206909 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567209922 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567212825 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1567213009 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition |
| RS1567214312 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1567214484 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Inherited breast cancer and ovarian cancer |
| RS1567217128 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567217830 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567217908 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast, Familial cancer of breast |
| RS1567217931 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567218141 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567218690 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567220758 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1567220784 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567220802 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS1567221328 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast, Familial cancer of breast |
| RS1567221417 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Colorectal cancer, Familial cancer of breast |
| RS1567221493 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567221851 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567222143 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567222476 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567222523 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, PALB2-related disorder |
| RS1567222580 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1567222725 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition |
| RS1567222943 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567223192 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567223942 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567224232 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS1597062296 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597066595 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597073266 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1597073423 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597079810 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597079941 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597081202 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597081571 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597082860 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597082866 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |