PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1555460542 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555460548 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Gastric cancer |
| RS1555460579 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460584 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555460592 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460593 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460609 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460628 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555460648 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460650 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461174 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461176 | Health Risk | Pathogenic | Malignant tumor of pancreas, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461178 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461192 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461253 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS1555461278 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461287 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461294 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS1555461295 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461323 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461339 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461363 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555461407 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS1555461408 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555461413 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461451 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555461460 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS1555461467 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461472 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461484 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461488 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461502 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461514 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461517 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461553 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555461558 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461574 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461586 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS1555461597 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, PALB2-related disorder |
| RS1555461606 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555461627 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Neuroendocrine tumor of pancreas |
| RS1555461684 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555461693 | Health Risk | Pathogenic | Breast neoplasm, Familial cancer of breast, Breast neoplasm |
| RS1555461695 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461697 | Health Risk | Pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461704 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461727 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast carcinoma |
| RS1555461733 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555461765 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS1555461777 | Health Risk | Pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |