RS2479409 PCSK9
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What This Variant Does
"Molecular population genetics of PCSK9: a signature of recent positive selection. [OMIM:?] [GWAS:No..."
Associated Conditions
Hypercholesterolemia
familial
1
autosomal dominant
3
Hypercholesterolemia
familial
1
autosomal dominant
3
GWAS Studies (11)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| LDL cholesterol | G | β: 0.064 | 3E-50 | PubMed |
| LDL cholesterol levels | A | β: 0.064 | 3E-42 | PubMed |
| Cholesterol, total | G | β: 0.054 | 2E-39 | PubMed |
| Total cholesterol levels | A | β: 0.054 | 1E-32 | PubMed |
| LDL cholesterol | G | OR: 2.01 | 2E-28 | PubMed |
| Cholesterol, total | G | OR: 1.96 | 4E-24 | PubMed |
| LDL x depression interaction (2df test) | A | OR: 1.47 | 1E-22 | PubMed |
| Low density lipoprotein cholesterol levels | G | β: 0.053 | 3E-20 | PubMed |
| Total cholesterol levels | G | β: 0.05 | 9E-19 | PubMed |
| LDL cholesterol levels | A | OR: 1.45 | 6E-16 | PubMed |
| Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease | A | β: 0.057 | 3E-7 | PubMed |
Other Variants in PCSK9