RS1799853 CYP2C9

Drug Response Chr 10:94942289 snv missense variant

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What This Variant Does

"rs1799853 is a SNP in the CYP2C9 gene and is linked to poor warfarin metabolism and risk of GI bleed...

Associated Conditions

Warfarin response

Lesinurad response

Flurbiprofen response

Piroxicam response

Phenytoin response

Warfarin response

Lesinurad response

Flurbiprofen response

Piroxicam response

Phenytoin response

Medication Interactions

Warfarin dose_adjustment strong

CYP2C9*2 — reduced metabolism, lower dose needed

Ibuprofen metabolism moderate

CYP2C9*2 — slower NSAID clearance

GWAS Studies (1)

Trait	Risk Allele	OR / Beta	P-value	Study
Warfarin maintenance dose	—	OR: 0.54	1E-31	PubMed

Population Frequencies

gnomAD ALL

88.2%

1kG AFR

99.2%

1kG ALL

4.8%

1kG AMR

90.1%

1kG EAS

99.9%

1kG EUR

87.6%

1kG SAS

3.5%

Other Variants in CYP2C9