RS1057910 CYP2C9

Drug Response Chr 10:94981295 snv missense variant

Upload your DNA to see your genotype for this variant.

What This Variant Does

"SNP rs1057910(A), located in the cytochrome p450 CYP2C9 gene, most commonly encodes the amino acid i...

Associated Conditions

Tolbutamide response

Warfarin response

Phenytoin response

Glipizide response

Flurbiprofen response

Piroxicam response

Lesinurad response

Tolbutamide response

Warfarin response

Phenytoin response

Glipizide response

Flurbiprofen response

Piroxicam response

Lesinurad response

Medication Interactions

Warfarin dose_adjustment strong

CYP2C9*3 — significantly reduced metabolism

GWAS Studies (1)

Trait	Risk Allele	OR / Beta	P-value	Study
Warfarin maintenance dose	—	OR: 1.11	3E-79	PubMed

ClinVar Assertions (2)

NM_000771.3(CYP2C9):c.[430C=;1075A>C]

· 1 submitter

CYP2C9*3

· 11 submitters

Population Frequencies

gnomAD ALL

6.5%

1kG AFR

99.8%

1kG ALL

95.1%

1kG AMR

3.7%

1kG EAS

3.4%

1kG EUR

7.3%

1kG SAS

10.9%

Other Variants in CYP2C9