CYP2C9 Chromosome 10
Cytochrome P450 family 2 subfamily C member 9
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What This Gene Does
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Cytochrome P450 family 2
Locus Type
gene with protein product
Location
10q23.33
Ensembl
ENSG00000138109
Associated Conditions (10)
Flurbiprofen response
Piroxicam response
Lesinurad response
Tolbutamide response
Warfarin response
Phenytoin response
Glipizide response
Pulmonary disease
chronic obstructive
susceptibility to
Key Variants
RS28371685
Benign/Likely benign; drug response
Flurbiprofen response, Piroxicam response, Lesinurad response
Drug Response
RS7900194
Benign/Likely benign; drug response
Lesinurad response, Piroxicam response, Flurbiprofen response
Drug Response
RS28371686
Benign/Likely benign; drug response; other
Lesinurad response, Flurbiprofen response, Piroxicam response
Drug Response
RS9332131
Benign/Likely benign; drug response; other
Lesinurad response, Flurbiprofen response, Piroxicam response
Drug Response
RS1057910
drug response; other
Tolbutamide response, Warfarin response, Phenytoin response
Drug Response
RS1799853
Likely benign; drug response; other
Warfarin response, Lesinurad response, Flurbiprofen response
Drug Response
RS1856908
association
Pulmonary disease, chronic obstructive, susceptibility to
Health Risk
RS9332220
association
Pulmonary disease, chronic obstructive, susceptibility to
Health Risk
RS72558191
Pathogenic
Warfarin response, Warfarin response
Health Risk
Drug Interactions (3)
Warfarin dose_adjustment
strong
CYP2C9*2 — reduced metabolism, lower dose needed
Warfarin dose_adjustment
strong
CYP2C9*3 — significantly reduced metabolism
Ibuprofen metabolism
moderate
CYP2C9*2 — slower NSAID clearance
All Variants (9)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS28371685 | Drug Response | Benign/Likely benign; drug response | Flurbiprofen response, Piroxicam response, Lesinurad response |
| RS7900194 | Drug Response | Benign/Likely benign; drug response | Lesinurad response, Piroxicam response, Flurbiprofen response |
| RS28371686 | Drug Response | Benign/Likely benign; drug response; other | Lesinurad response, Flurbiprofen response, Piroxicam response |
| RS9332131 | Drug Response | Benign/Likely benign; drug response; other | Lesinurad response, Flurbiprofen response, Piroxicam response |
| RS1057910 | Drug Response | drug response; other | Tolbutamide response, Warfarin response, Phenytoin response |
| RS1799853 | Drug Response | Likely benign; drug response; other | Warfarin response, Lesinurad response, Flurbiprofen response |
| RS1856908 | Health Risk | association | Pulmonary disease, chronic obstructive, susceptibility to |
| RS9332220 | Health Risk | association | Pulmonary disease, chronic obstructive, susceptibility to |
| RS72558191 | Health Risk | Pathogenic | Warfarin response, Warfarin response |