RS11206510 PCSK9

Health Risk Chr 1:55030365 snv intergenic variant
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What This Variant Does
"23andMe blog coronary artery disease and heart attack SNP Risk Version Effect *rs646776 T 1.19 *rs17..."
Associated Conditions
GWAS Studies (14)
Trait Risk Allele OR / Beta P-value Study
Low density lipoprotein cholesterol levels C β: 0.066 4E-103 PubMed
Apolipoprotein B levels C β: 0.064 2E-95 PubMed
Total cholesterol levels C β: 0.06 5E-84 PubMed
PCSK9 levels C β: 0.048 1E-17 PubMed
LDL cholesterol T OR: 3.04 4E-11 PubMed
LDL cholesterol T β: 0.03 1E-10 PubMed
Coronary artery disease (MTAG) C β: 0.026 3E-9 PubMed
Myocardial infarction (early onset) T OR: 1.15 1E-8 PubMed
Coronary artery disease T OR: 1.07 1E-8 PubMed
Coronary artery disease T OR: 1.08 2E-8 PubMed
LDL cholesterol C β: 0.09 4E-8 PubMed
Coronary heart disease T OR: 1.08 9E-8 PubMed
Low density lipoprotein cholesterol levels OR: 2.52 1E-7 PubMed
Myocardial infarction T OR: 1.08 7E-7 PubMed
Population Frequencies
1kG AFR
13.5%
1kG ALL
10.2%
1kG AMR
11.7%
1kG EAS
95.5%
1kG EUR
17.2%
1kG SAS
3.4%
Other Variants in PCSK9
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