RS769450 APOE

Drug Response Chr 19:44907186 snv intron variant

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What This Variant Does

"Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men"

Associated Conditions

Warfarin response

GWAS Studies (20)

Trait	Risk Allele	OR / Beta	P-value	Study
Apolipoprotein B levels	A	β: 0.051	3E-98	PubMed
Low density lipoprotein cholesterol levels	A	β: 0.048	2E-85	PubMed
C-reactive protein levels	A	β: 0.045	4E-76	PubMed
Total cholesterol levels	A	β: 0.04	2E-60	PubMed
Alzheimer's disease	A	—	3E-49	PubMed
NECTIN2/TNFRSF14 protein level ratio	—	β: 0.074	3E-26	PubMed
Alzheimer's disease or family history of Alzheimer's disease	A	—	1E-25	PubMed
Baseline memory	—	β: 0.077	7E-22	PubMed
Memory decline	—	β: 0.009	8E-21	PubMed
Alzheimer's disease	G	OR: 1.6	6E-19	PubMed
Aspartate aminotransferase to alanine aminotransferase ratio	A	β: 0.021	2E-18	PubMed
Lipoprotein (a) levels	A	β: 0.023	6E-18	PubMed
Memory decline	—	β: 0.009	6E-17	PubMed
Alanine aminotransferase levels	A	β: 0.02	2E-16	PubMed
Baseline memory	—	β: 0.072	6E-15	PubMed
Baseline memory	—	β: 0.068	2E-14	PubMed
Baseline memory in impaired cognition	—	OR: 0.12	4E-13	PubMed
Baseline memory	—	β: 0.069	5E-13	PubMed
Memory decline in impaired cognition	—	β: 0.015	3E-10	PubMed
Baseline memory	—	OR: 0.12	4E-10	PubMed

Population Frequencies

gnomAD ALL

35.1%

1kG AFR

35%

1kG ALL

67.3%

1kG AMR

70.3%

1kG EAS

78.2%

1kG EUR

58.8%

1kG SAS

34.4%

Other Variants in APOE