WNT10A Chromosome 2
Wnt family member 10A
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What This Gene Does
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Wnt family
Locus Type
gene with protein product
Location
2q35
Ensembl
ENSG00000135925
Associated Conditions (15)
Odonto-onycho-dermal dysplasia
Tooth agenesis
selective
4
Schöpf-Schulz-Passarge syndrome
2
WNT10A-related disorder
Inborn genetic diseases
Hypohidrotic ectodermal dysplasia
Ectodermal dysplasia
See cases
Ectodermal dysplasia WNT10A related
Squamous cell carcinoma of the head and neck
Ovarian serous cystadenocarcinoma
Bladder exstrophy-epispadias-cloacal extrophy complex
Key Variants
RS1057520655
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS116998555
Conflicting classifications of pathogenicity
Schöpf-Schulz-Passarge syndrome, Odonto-onycho-dermal dysplasia, Tooth agenesis
Health Risk
RS121908118
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS121908120
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS1283426045
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS1359098202
Conflicting classifications of pathogenicity
Tooth agenesis, selective, 4
Health Risk
RS1402990329
Conflicting classifications of pathogenicity
Tooth agenesis, selective, 4
Health Risk
RS141074983
Conflicting classifications of pathogenicity
Tooth agenesis, selective, 4
Health Risk
RS143463683
Conflicting classifications of pathogenicity
Schöpf-Schulz-Passarge syndrome, Odonto-onycho-dermal dysplasia, Tooth agenesis
Health Risk
RS145641272
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS146460077
Conflicting classifications of pathogenicity
Schöpf-Schulz-Passarge syndrome, Tooth agenesis, selective
Health Risk
RS146902156
Conflicting classifications of pathogenicity
Tooth agenesis, selective, 4
Health Risk
All Variants (128)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS756946393 | Health Risk | Pathogenic | Tooth agenesis, selective, 4 |
| RS761182689 | Health Risk | Pathogenic | Tooth agenesis, selective, 4 |
| RS775990266 | Health Risk | Pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS781237311 | Health Risk | Pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS886039453 | Health Risk | Pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS886039454 | Health Risk | Pathogenic | Tooth agenesis, selective, 4 |
| RS886041618 | Health Risk | Pathogenic | — |
| RS886055642 | Health Risk | Pathogenic | Tooth agenesis, selective, 4 |
| RS915439029 | Health Risk | Pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS1011303295 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Schöpf-Schulz-Passarge syndrome, Odonto-onycho-dermal dysplasia |
| RS111314129 | Health Risk | Pathogenic/Likely pathogenic | Tooth agenesis, selective, 4 |
| RS1203128182 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS121908119 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Schöpf-Schulz-Passarge syndrome, Tooth agenesis |
| RS121908121 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS1249944381 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS1268725013 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS1306584103 | Health Risk | Pathogenic/Likely pathogenic | Tooth agenesis, selective, 4 |
| RS1434390821 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS2106018205 | Health Risk | Pathogenic/Likely pathogenic | Tooth agenesis, selective, 4 |
| RS2106018397 | Health Risk | Pathogenic/Likely pathogenic | Tooth agenesis, selective, 4 |
| RS318240759 | Health Risk | Pathogenic/Likely pathogenic | Schöpf-Schulz-Passarge syndrome, Odonto-onycho-dermal dysplasia, Tooth agenesis |
| RS372993798 | Health Risk | Pathogenic/Likely pathogenic | Tooth agenesis, selective, 4 |
| RS543063101 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS750260671 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS762739726 | Health Risk | Pathogenic/Likely pathogenic | Tooth agenesis, selective, 4 |
| RS763506612 | Health Risk | Pathogenic/Likely pathogenic | Tooth agenesis, selective, 4 |
| RS764658964 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |
| RS773036759 | Health Risk | Pathogenic/Likely pathogenic | Odonto-onycho-dermal dysplasia, Tooth agenesis, selective |