WNT10A Chromosome 2

Wnt family member 10A
128 variants 128 Health Risk

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What This Gene Does
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Wnt family
Locus Type
gene with protein product
Location
2q35
Ensembl
ENSG00000135925
Associated Conditions (15)
Odonto-onycho-dermal dysplasia
Tooth agenesis
selective
4
Schöpf-Schulz-Passarge syndrome
2
WNT10A-related disorder
Inborn genetic diseases
Hypohidrotic ectodermal dysplasia
Ectodermal dysplasia
See cases
Ectodermal dysplasia WNT10A related
Squamous cell carcinoma of the head and neck
Ovarian serous cystadenocarcinoma
Bladder exstrophy-epispadias-cloacal extrophy complex
Key Variants
RS1057520655
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS116998555
Conflicting classifications of pathogenicity
Schöpf-Schulz-Passarge syndrome, Odonto-onycho-dermal dysplasia, Tooth agenesis
Health Risk
RS121908118
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS121908120
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS1283426045
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS1359098202
Conflicting classifications of pathogenicity
Tooth agenesis, selective, 4
Health Risk
RS1402990329
Conflicting classifications of pathogenicity
Tooth agenesis, selective, 4
Health Risk
RS141074983
Conflicting classifications of pathogenicity
Tooth agenesis, selective, 4
Health Risk
RS143463683
Conflicting classifications of pathogenicity
Schöpf-Schulz-Passarge syndrome, Odonto-onycho-dermal dysplasia, Tooth agenesis
Health Risk
RS145641272
Conflicting classifications of pathogenicity
Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
Health Risk
RS146460077
Conflicting classifications of pathogenicity
Schöpf-Schulz-Passarge syndrome, Tooth agenesis, selective
Health Risk
RS146902156
Conflicting classifications of pathogenicity
Tooth agenesis, selective, 4
Health Risk
All Variants (128)
RSID Category Clinical Significance Conditions
RS121908122 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS121908123 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Odonto-onycho-dermal dysplasia
RS1220645831 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS1221516695 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS1332945612 Health Risk Pathogenic Tooth agenesis, selective, 4
RS1371718238 Health Risk Pathogenic Tooth agenesis, selective, 4
RS1553623281 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Odonto-onycho-dermal dysplasia
RS1553623389 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Odonto-onycho-dermal dysplasia
RS1559414928 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS1559416138 Health Risk Pathogenic Tooth agenesis, selective, 4
RS1575233692 Health Risk Pathogenic Tooth agenesis, selective, 4
RS1575235227 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Odonto-onycho-dermal dysplasia
RS1944636041 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS1944637150 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Odonto-onycho-dermal dysplasia
RS1944671913 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS1944678383 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2106010718 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2106011673 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2106011732 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2106016170 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2106016227 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2106016293 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2106016375 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2106018239 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2106018559 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2106018668 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2106018717 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2469037067 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2469037138 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2469037164 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2469037169 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2469037358 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2469037478 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2470301204 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2470301384 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Odonto-onycho-dermal dysplasia
RS2470301392 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2470301479 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2470303448 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2470312288 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2470312297 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2470312303 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2470312717 Health Risk Pathogenic Tooth agenesis, selective, 4
RS2470312725 Health Risk Pathogenic WNT10A-related disorder, WNT10A-related disorder
RS2470312895 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS2470313345 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS377416834 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS561173643 Health Risk Pathogenic Tooth agenesis, selective, 4
RS561503117 Health Risk Pathogenic Odonto-onycho-dermal dysplasia, Tooth agenesis, selective
RS749297006 Health Risk Pathogenic Tooth agenesis, selective, 4
RS750190755 Health Risk Pathogenic Tooth agenesis, selective, 4
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