RAD51C Chromosome 17

RAD51 paralog C
625 variants 625 Health Risk

Upload your DNA to see your personal genotypes for variants in RAD51C.

What This Gene Does
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Info
Gene Group
"FA complementation groups|RAD51 paralogs"
Locus Type
gene with protein product
Location
17q22
Ensembl
ENSG00000108384
Associated Conditions (37)
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group O
Breast-ovarian cancer
familial
susceptibility to
3
Familial ovarian cancer
Malignant tumor of breast
RAD51C-related cancer predisposition
Hereditary breast ovarian cancer syndrome
RAD51C-related disorder
Ovarian cancer
Breast and/or ovarian cancer
Familial cancer of breast
Ovarian neoplasm
Breast carcinoma
Inherited ovarian cancer (without breast cancer)
Hereditary cancer
Premature ovarian insufficiency
Carcinoma of colon
+17 more conditions
Key Variants
RS1000113630
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
Health Risk
RS1006806353
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome
Health Risk
RS1057521598
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Malignant tumor of breast
Health Risk
RS1057522948
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Familial ovarian cancer
Health Risk
RS1060502586
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502587
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
Health Risk
RS1060502589
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502590
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O
Health Risk
RS1060502591
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502592
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502593
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1060502594
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
All Variants (625)
RSID Category Clinical Significance Conditions
RS1567789009 Health Risk Likely pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS1567799943 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome
RS1567817415 Health Risk Likely pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS1567817516 Health Risk Likely pathogenic Ovarian neoplasm, Ovarian serous cystadenocarcinoma, Breast-ovarian cancer
RS1598448639 Health Risk Likely pathogenic —
RS1598460983 Health Risk Likely pathogenic Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
RS1598467175 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2047959481 Health Risk Likely pathogenic Familial ovarian carcinoma, Breast-ovarian cancer, familial
RS2048502560 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2048893092 Health Risk Likely pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2143853790 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143929613 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143961536 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome
RS2143963488 Health Risk Likely pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2144044105 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2144060112 Health Risk Likely pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509262385 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509267906 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509276003 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509283581 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509283705 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS2509300604 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509312694 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509337492 Health Risk Likely pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509343956 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509344172 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509344483 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509344581 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509344663 Health Risk Likely pathogenic Gastric cancer, Breast-ovarian cancer, familial
RS2509363942 Health Risk Likely pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509364078 Health Risk Likely pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS2509364267 Health Risk Likely pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509369753 Health Risk Likely pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS587782036 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
RS730881930 Health Risk Likely pathogenic Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer
RS746870368 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS748589398 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
RS757128712 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
RS864622343 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS878855177 Health Risk Likely pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS1060502588 Health Risk Pathogenic Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1064795774 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1233795152 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS1330937621 Health Risk Pathogenic Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O
RS1363104728 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS1413186293 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS1466185247 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS1555593458 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome
RS1555593521 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1555593553 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
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