RAD51C Chromosome 17

RAD51 paralog C
625 variants 625 Health Risk

Upload your DNA to see your personal genotypes for variants in RAD51C.

What This Gene Does
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Info
Gene Group
"FA complementation groups|RAD51 paralogs"
Locus Type
gene with protein product
Location
17q22
Ensembl
ENSG00000108384
Associated Conditions (37)
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group O
Breast-ovarian cancer
familial
susceptibility to
3
Familial ovarian cancer
Malignant tumor of breast
RAD51C-related cancer predisposition
Hereditary breast ovarian cancer syndrome
RAD51C-related disorder
Ovarian cancer
Breast and/or ovarian cancer
Familial cancer of breast
Ovarian neoplasm
Breast carcinoma
Inherited ovarian cancer (without breast cancer)
Hereditary cancer
Premature ovarian insufficiency
Carcinoma of colon
+17 more conditions
Key Variants
RS1000113630
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
Health Risk
RS1006806353
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome
Health Risk
RS1057521598
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Malignant tumor of breast
Health Risk
RS1057522948
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Familial ovarian cancer
Health Risk
RS1060502586
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502587
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
Health Risk
RS1060502589
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502590
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O
Health Risk
RS1060502591
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502592
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502593
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1060502594
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
All Variants (625)
RSID Category Clinical Significance Conditions
RS1555593587 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
RS1555593670 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, RAD51C-related disorder
RS1555593715 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS1555594617 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS1555594912 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
RS1555597132 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS1555599274 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
RS1555602141 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary breast ovarian cancer syndrome
RS1567782755 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS1567782936 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS1567786232 Health Risk Pathogenic Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
RS1567786326 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1567786509 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS1567794476 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS1567799952 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS1598448896 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS1598460116 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS201529791 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary breast ovarian cancer syndrome
RS2047811523 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2047814459 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2047940629 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS2047940709 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2047953067 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2047954401 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome
RS2047956880 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2048020646 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2048269550 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2048272509 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2048273367 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2048273755 Health Risk Pathogenic Breast and/or ovarian cancer, Breast and/or ovarian cancer
RS2048274544 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2143670048 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143721294 Health Risk Pathogenic Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
RS2143725868 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS2143742992 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143744121 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143746632 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2143746667 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS2143746939 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2143747219 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2143747561 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS2143748292 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143749861 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2143798753 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143800709 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143801496 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2143801795 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2143801832 Health Risk Pathogenic —
RS2143849978 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143852568 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
« Prev 1 ... 7 8 9 10 11 12 13 Next »
Sign Up to Analyze Your DNA Log In