RAD51C Chromosome 17

RAD51 paralog C
625 variants 625 Health Risk

Upload your DNA to see your personal genotypes for variants in RAD51C.

What This Gene Does
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Info
Gene Group
"FA complementation groups|RAD51 paralogs"
Locus Type
gene with protein product
Location
17q22
Ensembl
ENSG00000108384
Associated Conditions (37)
Hereditary cancer-predisposing syndrome
Fanconi anemia complementation group O
Breast-ovarian cancer
familial
susceptibility to
3
Familial ovarian cancer
Malignant tumor of breast
RAD51C-related cancer predisposition
Hereditary breast ovarian cancer syndrome
RAD51C-related disorder
Ovarian cancer
Breast and/or ovarian cancer
Familial cancer of breast
Ovarian neoplasm
Breast carcinoma
Inherited ovarian cancer (without breast cancer)
Hereditary cancer
Premature ovarian insufficiency
Carcinoma of colon
+17 more conditions
Key Variants
RS1000113630
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
Health Risk
RS1006806353
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome
Health Risk
RS1057521598
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Malignant tumor of breast
Health Risk
RS1057522948
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Familial ovarian cancer
Health Risk
RS1060502586
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502587
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
Health Risk
RS1060502589
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502590
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O
Health Risk
RS1060502591
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502592
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
RS1060502593
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1060502594
Conflicting classifications of pathogenicity
Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
Health Risk
All Variants (625)
RSID Category Clinical Significance Conditions
RS2143853617 Health Risk Pathogenic Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer
RS2143853726 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Gastric cancer, Fanconi anemia complementation group O
RS2143930413 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2143961567 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS2143963184 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS2144044038 Health Risk Pathogenic Malignant tumor of breast, Malignant tumor of breast
RS2509260589 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509261130 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509261498 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509261635 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509262078 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS2509262182 Health Risk Pathogenic Gastric cancer, Gastric cancer
RS2509262234 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509262617 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509273650 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509273792 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509273847 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509274053 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509274346 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS2509274419 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS2509274733 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome
RS2509275021 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509275155 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial
RS2509275252 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509275801 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509275911 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509275974 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509276286 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509276500 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509281199 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509281642 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509281686 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509281880 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509282138 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509282144 Health Risk Pathogenic Fanconi anemia complementation group O, Breast-ovarian cancer, familial
RS2509282682 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509283109 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509283244 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509283453 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509299426 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Breast-ovarian cancer
RS2509299617 Health Risk Pathogenic Fanconi anemia complementation group O, RAD51C-related disorder, Breast-ovarian cancer
RS2509300481 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509300511 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509312994 Health Risk Pathogenic Fanconi anemia complementation group O, Fanconi anemia complementation group O
RS2509313550 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509313565 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group O, Hereditary cancer-predisposing syndrome
RS2509336795 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509336958 Health Risk Pathogenic Breast-ovarian cancer, familial, susceptibility to
RS2509337046 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS2509337177 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
« Prev 1 ... 8 9 10 11 12 13 Next »
Sign Up to Analyze Your DNA Log In