DICER1 Chromosome 14
Dicer 1, ribonuclease III
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What This Gene Does
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Gene Info
Gene Group
"Endoribonucleases|MicroRNA protein coding host genes|RISC loading complex subunits"
Locus Type
gene with protein product
Location
14q32.13
Ensembl
ENSG00000100697
Associated Conditions (37)
DICER1-related tumor predisposition
Hereditary cancer-predisposing syndrome
Pleuropulmonary blastoma
Euthyroid goiter
Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Rhabdomyosarcoma
embryonal
2
Ovarian cancer
DICER1-related disorder
Breast neoplasm
Primary intracranial sarcoma
DICER1-mutant
Sertoli-Leydig cell tumor
Follicular thyroid carcinoma
Papillary thyroid carcinoma
Cancer or benign tumor
Sarcoma
Pediatric high-grade glioma
Ovarian serous cystadenocarcinoma
+17 more conditions
Key Variants
RS1024226278
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1032236740
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Pleuropulmonary blastoma, Euthyroid goiter
Health Risk
RS1045097916
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1047347414
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503601
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503614
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Ovarian cancer
Health Risk
RS1060503616
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503631
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503632
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503647
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503649
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
Health Risk
RS1060503652
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Health Risk
All Variants (929)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2542407479 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542407738 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542439230 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542440284 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542440450 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542440600 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542442732 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542444831 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542446879 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542475308 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542475809 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS2542478461 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542478972 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542479940 | Health Risk | Pathogenic | Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |
| RS2542480045 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542480067 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542483597 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542485254 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542485412 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542485705 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542486252 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542488809 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542489725 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2542492765 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542493021 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542504933 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542508752 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542512303 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542598499 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542603102 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542603366 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542603877 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542683167 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542685293 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542688974 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2542689542 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542690534 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2542690750 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542692569 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542693297 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542695619 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542698384 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542698629 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542701336 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542704409 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542705456 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS2542705609 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542707708 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2542707852 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542708086 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |