DICER1 Chromosome 14
Dicer 1, ribonuclease III
Upload your DNA to see your personal genotypes for variants in DICER1.
What This Gene Does
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Gene Info
Gene Group
"Endoribonucleases|MicroRNA protein coding host genes|RISC loading complex subunits"
Locus Type
gene with protein product
Location
14q32.13
Ensembl
ENSG00000100697
Associated Conditions (37)
DICER1-related tumor predisposition
Hereditary cancer-predisposing syndrome
Pleuropulmonary blastoma
Euthyroid goiter
Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Rhabdomyosarcoma
embryonal
2
Ovarian cancer
DICER1-related disorder
Breast neoplasm
Primary intracranial sarcoma
DICER1-mutant
Sertoli-Leydig cell tumor
Follicular thyroid carcinoma
Papillary thyroid carcinoma
Cancer or benign tumor
Sarcoma
Pediatric high-grade glioma
Ovarian serous cystadenocarcinoma
+17 more conditions
Key Variants
RS1024226278
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1032236740
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Pleuropulmonary blastoma, Euthyroid goiter
Health Risk
RS1045097916
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1047347414
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503601
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503614
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Ovarian cancer
Health Risk
RS1060503616
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503631
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503632
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503647
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503649
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
Health Risk
RS1060503652
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Health Risk
All Variants (929)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2139987544 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139994282 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140000781 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140020153 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140024253 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140025115 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140025249 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140025659 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140025853 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140025976 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2140032822 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140033227 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140067347 | Health Risk | Pathogenic | — |
| RS2140067638 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140068325 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140068631 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140077758 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140122641 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2140122670 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140123124 | Health Risk | Pathogenic | — |
| RS2140123302 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140124458 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140125178 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140126563 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2140138808 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140200556 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140201228 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140204512 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140206143 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140206874 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140207003 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2140207293 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140208028 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140208697 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140233854 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140234094 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140259715 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140259890 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140259982 | Health Risk | Pathogenic | Euthyroid goiter, Euthyroid goiter |
| RS2140260882 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140278766 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS2140278878 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140279248 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140295512 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2140296865 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542403368 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542404026 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542405102 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542405788 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2542406552 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Euthyroid goiter, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |